DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and zgc:158427

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_017207457.1	Gene:	zgc:158427 / 790932	ZFINID:	ZDB-GENE-061215-110	Length:	579	Species:	Danio rerio

Alignment Length:	608	Identity:	139/608 - (22%)
Similarity:	261/608 - (42%)	Gaps:	86/608 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQF 82
            :||.|.|.|::|.|..|..:.| :::...|..:.|.|.|.::||.:::|...||:.::.:.||||
Zfish    10 ERGFWGKKTEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGVPLFLLETAMGQF 74

  Fly    83 SSSGFIAAF-RLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH 145
            :..|.|..: ||.||.:|:||........:.:|:::.:|..|.:||:||...||| ||:.:  |:
Zfish    75 THEGGITCWHRLCPLAQGIGYAGQLTVLYSCMYFTIILAWALFYLISSFSSQLPWASCDNI--WN 137

  Fly   146 NRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNT--------DKR-FDISRPLIGL 201
              ||....|                 |...|.|:...|...|:        ::| ..:|..:..:
Zfish   138 --TDNCVNL-----------------AAGNLTFNRTTQMLINSTSAATEFWERRVLSLSGGIEDI 183

  Fly   202 FTLSW----ALIA--IIFYH--FSEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYI 258
            ..::|    .|||  ||.|.  :......||.:.:......|:::|..:|.|.|||:.:.:..|:
Zfish   184 GKINWEILLCLIAMWIICYFCIWKGVKSTGKVVYFTATFPYVMLIVLLIRGLTLPGALQGIVFYL 248

  Fly   259 TPNTKDFSE-------GIYSTFIMALQAFGAGWGSVIALSSFNGFKTD-IMSYSW--IISFGQIF 313
            .|.....::       |....|     ::....|.:|:|.|:|.:..: .....|  :::.|..|
Zfish   249 YPEPARLADPQVWMEAGTQIFF-----SYSVIGGVLISLGSYNQYNNNCYRDCFWLCLLNSGTSF 308

  Fly   314 I--YIMFGLVSFMLEQY---YKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLL 373
            :  :.:|.::.||....   .::::::       ...:.|::...|:..:.:|.||...::.|::
Zfish   309 VAGFAVFSVLGFMAHVQGVPIEEVAES-------GPGLAFIAYPQAVAMMPFPQLWAVCFFIMII 366

  Fly   374 LASLTVIATQLFTVLQSLFDEFEKLKER--KQEVTFGIICGLAICSF---FFCTEHGSFYFAILG 433
            |..|......:..|:.|:.|.|.::..|  ::|:...::|  ..|.|   ...||.|.:.|.:..
Zfish   367 LLGLDTQFVSVECVITSVMDLFPEVLRRAGRRELLVLLLC--LTCFFGQLIMVTEGGMYVFQLFD 429

  Fly   434 IDVILAHSLLHLLLL--LVVLWIYGQKRFQRDIEFMLGQPFASWKVFILRYTAPIVFLICMILGI 496
            ........||.|.:.  |.:.||:|.::....||.|.......|.:...:|..|:|.|...:..:
Zfish   430 NYACNGACLLFLSVFESLAIGWIFGAEKMFDIIEDMTESRPNYWFMLCWKYLTPLVSLTSFVYSM 494

  Fly   497 IECIRVHF----FFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTDWYPVE 557
            :....:.|    .:.:...|||.:|.:...|.:|.:....:....|:..:|.:....|...:|:.
Zfish   495 VRYTPLTFNRWYIYPDWAYVLGWLLALSSILLVPAWALGQMCAGKGSLKQRWRHLSSPETNFPLS 559

  Fly   558 MKHRQHYGDRVGNIEMTDHLFNG 580
            .|..|..     ..||.|.|.:|
Zfish   560 FKQVQKQ-----TAEMEDLLKSG 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	117/510 (23%)
zgc:158427	XP_017207457.1	SLC6sbd-TauT-like	11..552	CDD:271387	130/575 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910