DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and slc6a4a

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001035061.1	Gene:	slc6a4a / 664719	ZFINID:	ZDB-GENE-060314-1	Length:	646	Species:	Danio rerio

Alignment Length:	586	Identity:	151/586 - (25%)
Similarity:	259/586 - (44%)	Gaps:	94/586 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SPDPKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSF 78
            |.||.|..|.|..|:|.:..|.|:.| :::...|..:.|.|...:|||.|..|...||:..:...
Zfish    86 SLDPPRETWSKKMDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYLLMAVFGGVPLFYMELA 150

  Fly    79 MGQFSSSGFIAAFR-LAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGL 141
            :|||..||.|:.:: :.|:|||:|:....:......||:..:|..|.:|::|||.|||| :|.
Zfish   151 LGQFHRSGCISIWKHVCPIFKGIGFAICIIALYIAFYYNTIMAWALYYLLSSFRATLPWTTCN-- 213

  Fly   142 KSWHNRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLSW 206
            ..|:.     |...|......:.::|....:|:..:  |:||..     :..:|..|..|..:||
Zfish   214 NRWNT-----PNCTHYLSTDLNVSWTNNSISPAEEF--YVRQVL-----QVHLSPGLHQLGWVSW 266

  Fly   207 AL-------IAIIFYHFSEPAK-FGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTK 263
            .|       ..::::...:..| .||.:........:::::..:|...|||:.:.:..|:.|:.|
Zfish   267 QLALCLLFIFTVVYFSIWKGVKTSGKVVWVTATFPYLVLLILLIRGATLPGAWRGVVFYLKPDWK 331

  Fly   264 DFSEGIYSTFI---MALQAF---GAGWGSVIALSSFNGFKTD-------IMSYSWIISFGQIFIY 315
            .    :.:|.:   .|.|.|   |.|:|.::|.:|:|.|..:       ..|.:.:.||  :..:
Zfish   332 K----LLTTTVWLDAAAQIFFSLGPGFGVLLAFASYNPFHNNCYKDALITSSVNCLTSF--LSGF 390

  Fly   316 IMFGLVSFM-------LEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLL 373
            ::|.::.:|       :|...||...::          ||:..|.|:..:.....:..|::.|::
Zfish   391 VIFTVLGYMAEMRQQGVETVAKDAGPSL----------LFIIYAEAIANMPAATFFAIIFFLMII 445

  Fly   374 LASLTVIATQLFTVLQSLFDEFEKLKERKQE-VTFGIICGLAICSFFFCTEHGSFYFAIL----- 432
            :..|......|..|:.::.|||..|..|::| ...|::|...:.:....|..|:|...:.
Zfish   446 MLGLDSTFAGLEGVITAMLDEFPHLLARRREWFVLGLVCVCYLGALSTLTYGGAFVVKLFEEYAT 510

  Fly   433 GIDVILAHSLLHLLLLLVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPIVFLICMILGI 496
            |..||    .:..|.::.|.|.||..||..|::.||| .|...|:|      ..|....|.:|.|
Zfish   511 GPAVI----TVVFLEVIAVSWFYGTTRFCNDVQLMLGFAPGLFWRV------CWIAICPCFLLFI 565

  Fly   497 IECIRVHF--FFKEVFL----------VLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCR 549
            |    |.|  |..||.|          |||..:.|..|:.:|.|..|:|..:.|||.:||.:...
Zfish   566 I----VSFLAFPPEVKLFDYLYPFWTTVLGYCIGVSSFICVPSYMVYHLVTTKGTFQQRLLKGIT 626

  Fly   550 P 550
            |
Zfish   627 P 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	122/506 (24%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:294310	148/581 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810