Protein Alignment CG33296 and SLC6A6

DIOPT Version :10

• Sequence 1: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 137/615 - (22%)
• Similarity: 252/615 - (40%)
• Gaps: 97/615 - (15%)

  Fly    10 GTKP----FSPDPKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYL 69
            ||:|    ....|:|.||....|::.:..|..:.| :::...|..:.|.|...::|||:::....
Human   128 GTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSG 192

  Fly    70 VPILVVHSFMGQFSSSGFIAAF-RLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPT 133
            :|:..:...:||::|.|.|..: ::.|||.|:||.|:.:.....:||.:.:|....:|..||:..
Human   193 LPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKE 257

  Fly   134 LPWS-CEGLKSWHNRTDEYPTLCHPTIYKQHE--------NYTL---------------GVEAPS 174
            |||: |.  .||:.     |.....|:.|...        |:|.               |::.|.
Human   258 LPWAHCN--HSWNT-----PHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPG 315

  Fly   175 RLYFDYIRQDYFNTDKRFDISRPLIGLFTLSWALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVV 239
            .|              ::|::..|:    |.|  :...|..:......||.:.:.......:::|
Human   316 SL--------------KWDLALCLL----LVW--LVCFFCIWKGVRSTGKVVYFTATFPFAMLLV 360

  Fly   240 CFVRFLFLPGSHKLLWMYITPNTK---------DFSEGIYSTFIMALQAFGAGWGSVIALSSFNG 295
            ..||.|.|||:...:..|:.|:..         |....|:.::.:.|       |::.:|.|:|.
Human   361 LLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICL-------GAMTSLGSYNK 418

  Fly   296 FK----TDIMSYSWIISFGQIFI--YIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASA 354
            :|    .|.|....:.| |..|:  :.:|.::.||.::...||:|...    ....:.|::...|
Human   419 YKYNSYRDCMLLGCLNS-GTSFVSGFAIFSILGFMAQEQGVDIADVAE----SGPGLAFIAYPKA 478

  Fly   355 LNTLGWPNLWTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEKL--KERKQEVTFGIICGLA-IC 416
            :..:..|..|:.:::.||||..|.....::...:.||.|.:...  |..::|:....:|.:: :.
Human   479 VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLL 543

  Fly   417 SFFFCTEHGSFYFAILGIDVILAHSLLHLLLL--LVVLWIYGQKRFQRDIEFMLGQPFASWKVFI 479
            .....||.|.:.|.:..........||.:...  .|:.||||.......||.|:|.....|..:.
Human   544 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYS 608

  Fly   480 LRYTAPIVFLICMILGIIECIRVHFFFKEVF----LVLGIILVVLPFLAIPGYGFYYLRQSPGTF 540
            .....|::.:.|.|..:::.:.:.:....|:    :.||..|.:...|.:|......|.|:.|.|
Human   609 WAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPF 673

  Fly   541 LERLKRSCRPTD---WYPVEMKHRQHYGDR 567
            |.|:|....|.:   | .||.:....|..|
Human   674 LVRVKYLLTPREPNRW-AVEREGATPYNSR 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	111/514 (22%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	127/579 (22%)