DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and SLC6A3

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001035.1	Gene:	SLC6A3 / 6531	HGNCID:	11049	Length:	620	Species:	Homo sapiens

Alignment Length:	566	Identity:	139/566 - (24%)
Similarity:	251/566 - (44%)	Gaps:	63/566 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            |..|.|..|:|.:..|.|:.| :::...|..:.|.|...::||.|:|||..:|:..:...:|||:
Human    60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFN 124

  Fly    84 SSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH-- 145
            ..|....:::.|:.||:|:..|.::.....:|::.:|..|.:|.:||...||| .|.  .||:
Human   125 REGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCN--NSWNSP 187

  Fly   146 NRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFD----YIRQDYFNTDKRFDISRPLIGLFTLSW 206
            |.:|.:|.  ..:......|.|.|. .|:..||:    ::.|.: ..|   |:..|...|.....
Human   188 NCSDAHPG--DSSGDSSGLNDTFGT-TPAAEYFERGVLHLHQSH-GID---DLGPPRWQLTACLV 245

  Fly   207 ALIAIIFYHFSEPAK-FGKCI------RYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKD 264
            .:|.::::...:..| .||.:      .|:|:|.::|      |.:.|||:...:..|::.:...
Human   246 LVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLL------RGVTLPGAIDGIRAYLSVDFYR 304

  Fly   265 FSEGIYSTFIMALQ----AFGAGWGSVIALSSFNGFKTD-------IMSYSWIISFGQIFIYIMF 318
            ..|.  |.:|.|..    :.|.|:|.:||.||:|.|..:       ..|.:.:.||...|  ::|
Human   305 LCEA--SVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGF--VVF 365

  Fly   319 GLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQ 383
            ..:.:|.:::...|.|...    ....::|:....|:.||...:.|..:::.|||...:......
Human   366 SFLGYMAQKHSVPIGDVAK----DGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGG 426

  Fly   384 LFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSFFFCTEHGSFYFAIL-----GIDVILAHSLL 443
            :.:|:..|.|||:.|...::..|..|:....:.|.|..|..|.:.|.:|     |..::..
Human   427 MESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFG---- 487

  Fly   444 HLLLLLVVLWIYGQKRFQRDIEFMLGQ-PFASWKVFILRYTAPIVFLICMILGIIECIRVH---F 504
            .|:..:.|.|.||..:|..||:.|.|| |...|:: ..:..:|...|..:::.|:.....|   :
Human   488 VLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRL-CWKLVSPCFLLFVVVVSIVTFRPPHYGAY 551

  Fly   505 FFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRP 550
            .|.:....||.::.......:|.|..|.....||:|.|:|..:..|
Human   552 IFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAP 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	122/500 (24%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	139/566 (25%)
SLC6A3	NP_001035.1	Interaction with TGFB1I1. /evidence=ECO:0000269\|PubMed:12177201	561..590		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810