Protein Alignment CG33296 and SLC6A3

DIOPT Version :10

• Sequence 1: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 139/566 - (24%)
• Similarity: 251/566 - (44%)
• Gaps: 63/566 - (11%)

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            |..|.|..|:|.:..|.|:.| :::...|..:.|.|...::||.|:|||..:|:..:...:|||:
Human    60 RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFN 124

  Fly    84 SSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH-- 145
            ..|....:::.|:.||:|:..|.::.....:|::.:|..|.:|.:||...||| .|.  .||:
Human   125 REGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCN--NSWNSP 187

  Fly   146 NRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFD----YIRQDYFNTDKRFDISRPLIGLFTLSW 206
            |.:|.:|.  ..:......|.|.|. .|:..||:    ::.|.: ..|   |:..|...|.....
Human   188 NCSDAHPG--DSSGDSSGLNDTFGT-TPAAEYFERGVLHLHQSH-GID---DLGPPRWQLTACLV 245

  Fly   207 ALIAIIFYHFSEPAK-FGKCI------RYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKD 264
            .:|.::::...:..| .||.:      .|:|:|.::|      |.:.|||:...:..|::.:...
Human   246 LVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLL------RGVTLPGAIDGIRAYLSVDFYR 304

  Fly   265 FSEGIYSTFIMALQ----AFGAGWGSVIALSSFNGFKTD-------IMSYSWIISFGQIFIYIMF 318
            ..|.  |.:|.|..    :.|.|:|.:||.||:|.|..:       ..|.:.:.||...|  ::|
Human   305 LCEA--SVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGF--VVF 365

  Fly   319 GLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQ 383
            ..:.:|.:::...|.|...    ....::|:....|:.||...:.|..:::.|||...:......
Human   366 SFLGYMAQKHSVPIGDVAK----DGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGG 426

  Fly   384 LFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSFFFCTEHGSFYFAIL-----GIDVILAHSLL 443
            :.:|:..|.|||:.|...::..|..|:....:.|.|..|..|.:.|.:|     |..::..
Human   427 MESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFG---- 487

  Fly   444 HLLLLLVVLWIYGQKRFQRDIEFMLGQ-PFASWKVFILRYTAPIVFLICMILGIIECIRVH---F 504
            .|:..:.|.|.||..:|..||:.|.|| |...|:: ..:..:|...|..:::.|:.....|   :
Human   488 VLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRL-CWKLVSPCFLLFVVVVSIVTFRPPHYGAY 551

  Fly   505 FFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRP 550
            .|.:....||.::.......:|.|..|.....||:|.|:|..:..|
Human   552 IFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAP 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	122/500 (24%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	139/566 (25%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		7/28 (25%)