DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and SLC6A1

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001335179.1	Gene:	SLC6A1 / 6529	HGNCID:	11042	Length:	599	Species:	Homo sapiens

Alignment Length:	564	Identity:	149/564 - (26%)
Similarity:	264/564 - (46%)	Gaps:	59/564 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQ 81
            |.|..|:...|:|.:|.|.|:.| :::...|....|.|...::||||.::...||:.::...:||
Human    42 PDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQ 106

  Fly    82 FSSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH 145
            ::|.|.:..::|||:|||:|..:..|:|...|||.:.::..:.:|.|||..|||| .|:  ..|:
Human   107 YTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCD--NPWN 169

  Fly   146 NRTDEYPTLCHPTIYKQHENYTL-----GVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLS 205
              ||.    |       ..||::     ...|....:...:.|.....||...|..||  ..||:
Human   170 --TDR----C-------FSNYSMVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPL--AITLA 219

  Fly   206 WALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKDFSEGIY 270
            .|.|.:.|..:......||.:.:......:::::.|.|.:.|||:.:.:..|||||.:..|:.
Human   220 IAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDS-- 282

  Fly   271 STFIMALQ----AFGAGWGSVIALSSFNGFKTDIMSYSWII----SFGQIFI-YIMFGLVSFMLE 326
            ..::.|..    ::|.|.||:|||.|:|.|..::...|.|:    |...:|. :::|.:|.||..
Human   283 EVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAH 347

  Fly   327 QYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQLFTV---L 388
            ...:.|:|...    ....:.||:...|:..|....||..:::||||:..   |.:|..||   :
Human   348 VTKRSIADVAA----SGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLG---IDSQFCTVEGFI 405

  Fly   389 QSLFDEFEKLKERKQEVTFGIICGLAICSFFF----CTEHGSFYFAILGIDVILAHSLLHLLLL- 448
            .:|.||:.:|...::|:....:|   |.|:..    .|:.|.:.|.:.........|||.|:..
Human   406 TALVDEYPRLLRNRRELFIAAVC---IISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFE 467

  Fly   449 -LVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPIVFLICMILGIIECIRV---HFFFKE 508
             :.:.|.||..||..:|:.|:| :|...||:....:| ||:.....|...::...:   ::.|.:
Human   468 CVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFT-PIIVAGVFIFSAVQMTPLTMGNYVFPK 531

  Fly   509 VFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTD 552
            ....:|.::.:...:.||||..|......|:..:|::...:|::
Human   532 WGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSE 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	136/494 (28%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	149/564 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910