DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and slc6a2

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_009301625.1	Gene:	slc6a2 / 565776	ZFINID:	ZDB-GENE-110408-4	Length:	625	Species:	Danio rerio

Alignment Length:	586	Identity:	142/586 - (24%)
Similarity:	255/586 - (43%)	Gaps:	46/586 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVYETSYASGTKPFSPDPKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLY 64
            :|...|..:.|.....:.:|..|.|..|:|.:..|.|:.| :::...|..:.|.|...::||.|:
Zfish    45 VVASPSSRACTSASGEEIERETWGKKMDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLIPYVLF 109

  Fly    65 MVIYLVPILVVHSFMGQFSSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINS 129
            :.|..:|:..:...:||::..|....:::.|:|||:||..|.:......||::.:|..|.:|..|
Zfish   110 LFIAGMPLFYMELALGQYNREGAATLWKICPVFKGVGYTVIVIALYVGFYYNVIIAWSLYYLYAS 174

  Fly   130 FRPTLPW-SCEGLKSWHNRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNTDKRFD 193
            ....||| .|.  ..|::.....|...:.|:.....:|......|:..:::   :...::.:...
Zfish   175 LTSELPWLHCN--NPWNSPNCTEPKDINGTVLGNGTSYAKYKNTPAAEFYE---RGVLHSHESKG 234

  Fly   194 ISRPLIGL----FTLSWALIAIIFYH--FSEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHK 252
            |..  :||    .|:...::|.|.|.  :......||.:........::::|..:|.:.|||:..
Zfish   235 IGD--LGLPRWELTICLVVVAFILYFSLWKGVKSSGKVVYITATMPYIVLLVLLIRGITLPGAMN 297

  Fly   253 LLWMYITPNTKDFSEGIYSTFI-MALQAF---GAGWGSVIALSSFNGFKT----DIMSYSWIISF 309
            .:..|:..:.|..:..  ..:| .|.|.|   |||:|.:||.||:|.|..    |.:..|.|...
Zfish   298 GIRAYLHIDLKKLNNP--QVWIDAATQIFFSLGAGFGVLIAFSSYNKFNNNCYRDAILTSTINCV 360

  Fly   310 GQIFI-YIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLL 373
            ...|. :.:|.::.:|.||:..:|.|...    ....::|:....|::||.....:..:::.|||
Zfish   361 TSFFSGFAIFSVLGYMAEQHKVNIKDVAT----EGAGLVFVIYPEAISTLPGATFFAIVFFIMLL 421

  Fly   374 LASLTVIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSFFFCTEHGSFYFAILGIDVIL 438
            ...:......:..||..|.|:|:.||..::..||..:.|..:.: ..|..:|..|...|......
Zfish   422 TLGIDSSMGGMEAVLTGLSDDFKILKRNRKLFTFATVVGTFLMA-LLCVTNGGIYVLTLLDKYAA 485

  Fly   439 AHSLLHLLLL--LVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPIVFLICMILGIIECI 500
            ..|:|..:|.  :.|.|.||..||..|||.|:| :|...|:: ..::.:|...|:.:|..|:...
Zfish   486 GTSILFGVLFEAIGVSWFYGVDRFSEDIERMMGFKPGIYWRL-CWKFVSPAFLLLVVIASIVTSG 549

  Fly   501 RV---HFFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTDWYPVEMKHRQ 562
            |:   .:.|.....:||..:.:...|.:|.|..|.....|.:|.|||.        |.|..:|..
Zfish   550 RLTYDEYVFPYWADMLGWSIALSSMLFVPFYAIYKFFSVPSSFKERLA--------YCVTPEHEH 606

  Fly   563 H 563
            |
Zfish   607 H 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	118/488 (24%)
slc6a2	XP_009301625.1	SLC5-6-like_sbd	64..623	CDD:294310	139/567 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910