DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	590	Identity:	139/590 - (23%)
Similarity:	249/590 - (42%)	Gaps:	89/590 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KPFSPDPKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVV 75
            ||    |.|.:|....::|.|..|..:.| :::...|..:.|.|....:||.|::....:|:..:
Zfish    24 KP----PAREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFVPYVLFLFTCGIPLFFL 84

  Fly    76 HSFMGQFSSSGFIAAFR-LAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SC 138
            .:.:|||:|.|.|..:| :.|||:|:|:.|..:...|.:||.:.:|...|:|.:||...||| ||
Zfish    85 ETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAWAFLYLFSSFTSELPWASC 149

  Fly   139 EGLKSWH----------NRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNTDKRFD 193
            ...  |:          |.|:..|......:.:..|...||:...       |.|   ..:.|:|
Zfish   150 NNY--WNTPSCMEFSESNITEYSPNKTTSPVIEFWERRILGLSGG-------IEQ---IGNVRWD 202

  Fly   194 ISRPLIGLFTLSWALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYI 258
            ::..|:    |:|  |...|..:......||.:.:......::::|..||.|.|||:...:..|:
Zfish   203 LALCLL----LAW--IICYFCVWKGVKSTGKVVYFTATFPYLMLIVLLVRGLTLPGAINGITFYL 261

  Fly   259 TPN---TKD-------FSEGIYSTFIMALQAFGAGWGSVIALSSFNGFKTDIMS---YSWIISFG 310
            .|:   .||       .|:..||        :|...|.:.||.|:|.:..:...   |..:::..
Zfish   262 YPDPSRLKDPQVWMDAGSQIFYS--------YGVCTGVLTALGSYNKYDNNCYRDCVYLCLLNSL 318

  Fly   311 QIFI--YIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLL 373
            ..|:  :.:|.::.||.::...|||  :|..  ....:.|::...|:..:..|.||...::.|::
Zfish   319 TSFVAGFAIFSVLGFMADEQGVDIS--LVAE--SGPGLAFIAYPRAVALMPLPQLWAIFFFIMII 379

  Fly   374 LASLT---VIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSFF----FCTEHGSFYFAI 431
            ...|.   |....|.|.:..::..|.::..|::.:.. .||.   .|||    ..||.|.:.|.:
Zfish   380 FLGLDSEFVYQEALVTSISDMYPSFFQVGHRRKFLLL-FICS---ASFFVGLLMVTEGGLYVFQL 440

  Fly   432 LGIDVILAHSLLHLLLL--LVVLWIYGQKRFQRDIEFMLGQ---PF--ASWKVFILRYTAPIVFL 489
            .........:||...:|  :.|.|:||..|....:|.|:|.   ||  ..||     |..|.:..
Zfish   441 FDYYACSGMTLLTFAILQSICVGWVYGADRHYDCVEDMIGYRPWPFMKCCWK-----YLTPAICT 500

  Fly   490 ICMILGIIECIRVHFFFKEVF----LVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRP 550
            ...|..:::...:.|..:..:    ..:|....:...|.:|.:..|.:..:||:..:|::..|.|
Zfish   501 GTFIFSLVQYTPLKFNNEYEYPWWGYAIGGFFTLSSTLLVPLWMIYLVGTTPGSMRQRVRALCTP 565

  Fly   551 TDWYP 555
            .:..|
Zfish   566 AEDLP 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	123/510 (24%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	134/575 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000