DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and Slc6a12

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_059031.1	Gene:	Slc6a12 / 50676	RGDID:	620255	Length:	628	Species:	Rattus norvegicus

Alignment Length:	597	Identity:	126/597 - (21%)
Similarity:	246/597 - (41%)	Gaps:	113/597 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            ||:|....:::.:..|..:.| :::...|..:.|.|....:|||::.....:|:..:...:||:|
  Rat    50 RGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYS 114

  Fly    84 SSGFIAAFR-LAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH- 145
            |.|.:.|:| :.||.:|:|..|:.:.....|||.:.:|..|.:|.:||...||| :|  ..||:
  Rat   115 SQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTC--TNSWNT 177

  Fly   146 -----------NRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNTDKRFDISRPLI 199
                       .|...|           .||:|    :|...:::         .:...|:..:.
  Rat   178 EHCVDFLNYSSTRAASY-----------SENFT----SPVMEFWE---------RRVLGITSGIH 218

  Fly   200 GLFTLSW-----ALIAIIFYHF---SEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWM 256
            .|.:|.|     .|:|.|..:|   ......||.:.:......:::::..:|.:.|||:::.:..
  Rat   219 DLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVF 283

  Fly   257 YITPNT---------KDFSEGIYSTFIMALQAFGAGWGSVIALSSFNGFKTDIMSYSWIISF--- 309
            |:.|:.         .|....|:.:|.:.       .|.:.||.|:|.:..:....|..:.|
  Rat   284 YLKPDLLRLKDPQVWMDAGTQIFFSFAIC-------QGCLTALGSYNKYHNNCYRDSIALCFLNS 341

  Fly   310 GQIFI--YIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSML 372
            ...|:  :::|.::.||.::....||:...    ....:.|::...|:..:....||:.:::.||
  Rat   342 ATSFVAGFVVFSILGFMAQEQGVPISEVAE----SGPGLAFIAFPKAVTMMPLSQLWSCLFFLML 402

  Fly   373 L---LASLTVIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSFFFCTEHGSF------Y 428
            |   |.|..|....|.|....:|.:..:.:.|::.:...:.....:......||.|.:      |
  Rat   403 LFLGLDSQFVCMECLVTASMDMFPQQLRKRGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDY 467

  Fly   429 FAILGIDVILAHSLLHLLLLLVVLWIYGQKRFQRDIEFMLGQPFASWKVFILRYTAPIVFLICMI 493
            :|..||.::    .|.|..::.:.|:||..||..::|.|:|  :..|         |:|.:..:.
  Rat   468 YASSGICLL----FLSLFEVICIGWVYGADRFYDNVEDMIG--YRPW---------PLVKISWLF 517

  Fly   494 LGIIECIRVHFF---------FKEVFLV------LGIILVVLPFLAIPGYGFYYLRQSPGTFLER 543
            |....|:...||         :..|::.      :|.:|.......:|.:....|.::.|:|.:|
  Rat   518 LTPGLCLATFFFSLSKYTPLKYNNVYIYPSWGYSIGWLLAFSSMACVPLFIIITLLKTQGSFKKR 582

  Fly   544 LKRSCRPTDWYP 555
            |:|...|....|
  Rat   583 LQRLITPDPSLP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	108/514 (21%)
Slc6a12	NP_059031.1	SLC5-6-like_sbd	49..589	CDD:294310	124/590 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000