DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and slc6a5

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001009557.1	Gene:	slc6a5 / 494450	ZFINID:	ZDB-GENE-050105-2	Length:	786	Species:	Danio rerio

Alignment Length:	615	Identity:	157/615 - (25%)
Similarity:	276/615 - (44%)	Gaps:	83/615 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            ||.|....|::.:..|.|:.| :::...|..|.|.|...::||.:.:.:..:||.::...:|||:
Zfish   177 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLGLAGIPIFLLEVSLGQFA 241

  Fly    84 SSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWHN- 146
            |.|.::.::..|..:|.|...:.::....|||::.:...|.:|..|.:.|||| :|:  ..|:.
Zfish   242 SQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNIIMCWTLYYLFASLKETLPWATCK--NEWNTV 304

  Fly   147 RTDEYPTLCHPTIYKQHENYT--------------------LGVEAPSRLYF----DYIRQDYFN 187
            ...:...|...|...:..|.|                    |.|...::.|.    :|.:.:..:
Zfish   305 ECKDKDMLLLDTCILRDRNITSIKNTTFCLSANVVGNLSKLLNVTVDNKTYVSPSEEYFKYNVLH 369

  Fly   188 TDKRF----DISRPLIGLFTLSWALIAIIFYHFSEPAK----FGKCIRYMVITTMVLVVVCFVRF 244
            ..|..    ||..||.....|:|.::      ::..||    .||.:.:......|::|:..:|.
Zfish   370 ISKGIEYPGDIRWPLAACLFLAWLIV------YASLAKGIKSSGKVVYFTATFPYVVLVILLIRG 428

  Fly   245 LFLPGSHKLLWMYITPNTKDFSEG-IYSTFIMALQAF---GAGWGSVIALSSFNGFKTDIMSYSW 305
            :.|||:...:..:|||..:..::. ::..  .|.|.|   .|.||.:|.|||:|.|..:....:.
Zfish   429 VTLPGAGSGILYFITPKWEKLNDAKVWKD--AATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTL 491

  Fly   306 II----SFGQIFI-YIMFGLVSFM---LEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPN 362
            |:    |...||. :::|.::.||   |:...:.::|.       ...:.|:....||..|....
Zfish   492 IVTCTNSATSIFAGFVIFSVIGFMAHELKVPIESVADE-------GPGIAFVVYPEALTRLPLSP 549

  Fly   363 LWTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLA--ICSFFFCTEHG 425
            .|..|::.|||...|..:...:.|::.|:.|||.|.. ||.:..|.::|.|:  :..|...||.|
Zfish   550 FWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFPKYL-RKHKPQFTLVCCLSFFVLGFPMITESG 613

  Fly   426 SFYFAILGIDVILA-HSLLHLLL--LLVVLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPI 486
            .:...:  :|...| :||:.:.:  |:.:.:|||.:||..|||.|:| ||...|:| ...:..|.
Zfish   614 MYMLQL--VDTFAASYSLVIIAIFELVGISYIYGLQRFCEDIEMMIGFQPNKFWRV-CWAFVTPT 675

  Fly   487 VFLICMILGIIE---CIRVHFFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSC 548
            :....:.|.:.:   .....:.:....:|||.::|:...:.||......:..:||:.:||||..|
Zfish   676 ILTFILALSLYQWKVMTYEDYTYPNWSMVLGWLMVICSVIWIPIMFAIKMHLAPGSLIERLKLVC 740

  Fly   549 RP-TDWYPVEMKHRQHYGDRVGNIEMTDHL 577
            .| .||.|..||||   |:|..|  |.|.|
Zfish   741 SPQPDWGPFLMKHR---GERYKN--MIDPL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	127/521 (24%)
slc6a5	NP_001009557.1	SLC5-6-like_sbd	177..775	CDD:294310	157/615 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810