DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and SerT

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001369117.1	Gene:	SerT / 37895	FlyBaseID:	FBgn0010414	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	136/590 - (23%)
Similarity:	255/590 - (43%)	Gaps:	68/590 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TSYASGTKPFSP--------------DPKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIG 54
            |:.|..|.|.:|              :..|..|.:..::|.|..|.|:.| :::...|..:.|.|
  Fly    45 TTPAKVTDPLAPKLANNERILVVSVTERTRETWGQKAEFLLAVIGFAVDLGNVWRFPYICYQNGG 109

  Fly    55 FVGMLPYFLYMVIYLVPILVVHSFMGQFSSSGFIAAF-RLAPLFKGMGYVSIFLTFTTLIYYSMF 118
            ...::||.|:::...:|:..:...:|||...|.::.: |:.|..||:||....:.....:||:..
  Fly   110 GAFLVPYCLFLIFGGLPLFYMELALGQFHRCGCLSIWKRICPALKGVGYAICLIDIYMGMYYNTI 174

  Fly   119 VAIPLLFLINSFRPTLPW-SCEGLKSWHNRTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFD-YI 181
            :...:.:|..||...||| ||:  ..|:.......|         .||:|....:|::.:|: .:
  Fly   175 IGWAVYYLFASFTSKLPWTSCD--NPWNTENCMQVT---------SENFTELATSPAKEFFERKV 228

  Fly   182 RQDYFNTDKRF------DISRPLIGLFTLSWALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVVC 240
            .:.|......|      .::..:.|:|.|      :.|..:......||.:....:...|::::.
  Fly   229 LESYKGNGLDFMGPVKPTLALCVFGVFVL------VYFSLWKGVRSAGKVVWVTALAPYVVLIIL 287

  Fly   241 FVRFLFLPGSHKLLWMYITP------NTKDFSEGIYSTFIMALQAFGAGWGSVIALSSFNGFKTD 299
            .||.:.|||:.:.:..|:||      |:|.:.:.....|.    :.|.|:|:::||||:|.|..:
  Fly   288 LVRGVSLPGADEGIKYYLTPEWHKLKNSKVWIDAASQIFF----SLGPGFGTLLALSSYNKFNNN 348

  Fly   300 IMSYSWIISFGQIFIYIMFGLVSFMLEQYYKDISDTIVFH-RIMNFWVLFLSSASALNTLGWPNL 363
            ....:.|.|........:.|.|.|.:..|...:..|.:.. .:....::|:....|:.|:.....
  Fly   349 CYRDALITSSINCLTSFLAGFVIFSVLGYMAYVQKTSIDKVGLEGPGLVFIVYPEAIATMSGSVF 413

  Fly   364 WTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSFFFCTEHGSFY 428
            |:.|::.||:...|......|..::.:|.||:.::..|::|    :...|.:...|.|......|
  Fly   414 WSIIFFLMLITLGLDSTFGGLEAMITALCDEYPRVIGRRRE----LFVLLLLAFIFLCALPTMTY 474

  Fly   429 FAILGIDVILAH--SLLHLLLLLV----VLWIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPI 486
            ..::.::.:..:  .|..|.::.|    |.|.||..||..|:|.||| :|...|:: ...|.:|:
  Fly   475 GGVVLVNFLNVYGPGLAILFVVFVEAAGVFWFYGVDRFSSDVEQMLGSKPGLFWRI-CWTYISPV 538

  Fly   487 VFL---ICMILGIIECIRVHFFFKEVFLVLGIILVVLPFLAIPGYGFY-YLRQSPGTFLERLKRS 547
            ..|   |..|:|..|.:...:::.:....:|..:.....|.||.|..| :...|.|...:||:.|
  Fly   539 FLLTIFIFSIMGYKEMLGEEYYYPDWSYQVGWAVTCSSVLCIPMYIIYKFFFASKGGCRQRLQES 603

  Fly   548 CRPTD 552
            .:|.|
  Fly   604 FQPED 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	114/495 (23%)
SerT	NP_001369117.1	SLC6sbd_SERT-like	74..607	CDD:271388	129/558 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840