DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and slc6a22.1

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_005166076.1	Gene:	slc6a22.1 / 368923	ZFINID:	ZDB-GENE-030616-629	Length:	584	Species:	Danio rerio

Alignment Length:	589	Identity:	124/589 - (21%)
Similarity:	246/589 - (41%)	Gaps:	95/589 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            ||:|....:::.|..|..:.| :::...|..:.|.|.|..:||.:::....:|:.::.:.:||::
Zfish    30 RGQWSSKVEFILAVAGQIIGLGNVWRFPYLCYKNGGGVFFIPYVVFLFACGIPLFLMETALGQYT 94

  Fly    84 SSGFIAAFR-LAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWHN 146
            |.|.:..:| :.|||:|:||.|..:...:..||.:.:|....:|.:||...||| ||   ::|.|
Zfish    95 SQGSVTCWRKICPLFEGLGYGSQVVVLYSSAYYIIILAWAFFYLFSSFSGELPWASC---RNWWN 156

  Fly   147 RTD--EYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLSW--- 206
            ..:  |:..:..    .::.::.....:|.:.:::         .:..:|:..:..|.::.|
Zfish   157 SENCVEFDRMQG----AKNLSFMANASSPVKEFWE---------RRVLNITGSVNELGSVRWELA 208

  Fly   207 --ALIAIIFYHF---SEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNT---- 262
              .|:|.:..:|   ......||.:.:......|:::|..:|.|.|||:...:..|:.||.
Zfish   209 LCLLLAWVICYFCVWKGVKSTGKVVYFTATFPYVMLMVLLIRGLTLPGAIDGITFYLYPNPARLA 273

  Fly   263 -----KDFSEGIYSTFIMALQAFGAGWGSVIALSSFNGFKTDIMS---YSWIISFGQIFI--YIM 317
                 .|....|:.::.:.:       |.:.||.|:|.:..:...   |..:::.|..|:  :.:
Zfish   274 DPQVWMDAGTQIFYSYALCI-------GCLTALGSYNKYNNNCYKDCVYLCLLNSGTSFVAGFAI 331

  Fly   318 FGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWP---------NLWTFIYYSMLL 373
            |.::.||..:...|||             :...|...|..:.:|         .||:..::.|::
Zfish   332 FSVLGFMALEQGVDIS-------------VVAESGPGLAFIAYPRAVAMMPMAQLWSICFFLMII 383

  Fly   374 LASLT---VIATQLFTVLQSLFDEFEKLKERKQEVTFGIIC-GLAICSFFFCTEHGSFYFAILGI 434
            |..|.   |....|.|.:..:...| .|:..::::...:|| ...:......||.|.:.|.:...
Zfish   384 LLGLDSEFVGLESLMTAITDMNPNF-FLQGHRRKLFLLVICIACFLIGLLMVTEGGLYVFQLFDY 447

  Fly   435 DVILAHSLLHLLLLLVVL-------WIYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPIVFLIC 491
                 :|...:.|||..:       |.||..|...:|..|:| .|....| :..:|..|||.:..
Zfish   448 -----YSCSGMTLLLFAIAQSICIGWFYGADRLYENIADMIGYHPLTLMK-YCWKYITPIVCIGT 506

  Fly   492 MILGIIECIRVHFFFKEVF----LVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTD 552
            .|..:::...:.|.....:    ...|....:...|.:|.:..|.:..:|||..:||:..|.|..
Zfish   507 FIFSLVKFTPLKFNNTYEYPWWGYAAGWWFTLSSTLLVPIWMIYAILVTPGTLKQRLRVLCTPAS 571

  Fly   553 WYPV 556
            ..|:
Zfish   572 DLPL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	108/516 (21%)
slc6a22.1	XP_005166076.1	SLC6sbd-TauT-like	30..569	CDD:271387	122/581 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000