DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and Slc6a6

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_008761345.1	Gene:	Slc6a6 / 29464	RGDID:	61912	Length:	631	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	132/599 - (22%)
Similarity:	245/599 - (40%)	Gaps:	97/599 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GTKP----FSPDPKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYL 69
            ||:|    ....|:|.||....|::.:..|..:.| :::...|..:.|.|...::|||:::....
  Rat    37 GTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSG 101

  Fly    70 VPILVVHSFMGQFSSSGFIAAF-RLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPT 133
            :|:..:...:||::|.|.|..: ::.|||.|:||.||.:.....:||.:.:|....:|..||:..
  Rat   102 LPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFQSFQKD 166

  Fly   134 LPWS-CEGLKSWHNRTDEYPTLCHPTIYKQHE--------NYT---------------LGVEAPS 174
            |||: |.  .||:.     |.....|:.:...        |:|               .|::.|.
  Rat   167 LPWAHCN--HSWNT-----PQCMEDTLRRNESHWVSLSAANFTSPVIEFWERNVLSLSSGIDHPG 224

  Fly   175 RLYFDYIRQDYFNTDKRFDISRPLIGLFTLSWALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVV 239
            .|              ::|::..|:    |.|  :...|..:......||.:.:.......:::|
  Rat   225 SL--------------KWDLALCLL----LVW--LVCFFCIWKGVRSTGKVVYFTATFPFAMLLV 269

  Fly   240 CFVRFLFLPGSHKLLWMYITPNTK---------DFSEGIYSTFIMALQAFGAGWGSVIALSSFNG 295
            ..||.|.|||:.:.:..|:.||..         |....|:.::.:.|       |::.:|.|:|.
  Rat   270 LLVRGLTLPGAGEGIKFYLYPNISRLEDPQVWIDAGTQIFFSYAICL-------GAMTSLGSYNK 327

  Fly   296 FK----TDIMSYSWIISFGQIFI--YIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASA 354
            :|    .|.|....:.| |..|:  :.:|.::.||.::...||:|...    ....:.|::...|
  Rat   328 YKYNSYRDCMLLGCLNS-GTSFVSGFAIFSILGFMAQEQGVDIADVAE----SGPGLAFIAYPKA 387

  Fly   355 LNTLGWPNLWTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEKL--KERKQEVTFGIICGLA-IC 416
            :..:..|..|:.:::.||||..|.....::...:.||.|.:...  |..::|:...|:|.:: :.
  Rat   388 VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAIVCSISYLL 452

  Fly   417 SFFFCTEHGSFYFAILGIDVILAHSLLHLLLL--LVVLWIYGQKRFQRDIEFMLGQPFASWKVFI 479
            .....||.|.:.|.:..........||.:...  .|:.||||.......||.|:|.....|..:.
  Rat   453 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYS 517

  Fly   480 LRYTAPIVFLICMILGIIECIRVHFFFKEVF------LVLGIILVVLPFLAIPGYGFYYLRQSPG 538
            .....|.:.:.|.|..:::  .|...:.:|:      :.||..|.:...:.||......|.::.|
  Rat   518 WAVITPALCVGCFIFSLVK--YVPLTYNKVYRYPDWAIGLGWGLALSSMVCIPLVIVILLCRTEG 580

  Fly   539 TFLERLKRSCRPTD 552
            ....|:|....|.:
  Rat   581 PLRVRIKYLITPRE 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	113/514 (22%)
Slc6a6	XP_008761345.1	SLC5-6-like_sbd	51..592	CDD:382020	127/581 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.000