Protein Alignment CG33296 and Slc6a4

DIOPT Version :10

• Sequence 1: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_037166.2
• Gene: Slc6a4 / 25553
• RGDID: 3714
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 593
• Identity: 151/593 - (25%)
• Similarity: 266/593 - (44%)
• Gaps: 81/593 - (13%)

  Fly    19 KRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQF 82
            :|..|.|..|:|.:..|.|:.| :|:...|..:.|.|...:|||.:..:...:|:..:...:||:
  Rat    78 ERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142

  Fly    83 SSSGFIAAFR-LAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWH 145
            ..:|.|:.:| :.|:|||:||....:.|....||:..:|..|.:||:|....||| ||  ..||:
  Rat   143 HRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSC--TNSWN 205

  Fly   146 NRTDEYPTLCHPTIYKQHEN--YTLGVEAPS-RLYFDYIRQDYFNTDKRFDISRPLIGLFTLSWA 207
            ...      |  |.|...:|  :||...:|: ..|..::.|        ...|:.|..|.|:||.
  Rat   206 TGN------C--TNYFAQDNITWTLHSTSPAEEFYLRHVLQ--------IHQSKGLQDLGTISWQ 254

  Fly   208 L-------IAIIFYHFSEPAK-FGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKD 264
            |       ..:|::...:..| .||.:........:::.|..||...|||:.:.:..|:.||.:.
  Rat   255 LTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQK 319

  Fly   265 FSE-GIYSTFIMALQAF---GAGWGSVIALSSFNGFKTDIMSYSWIISFGQI---FI--YIMFGL 320
            ..| |::..  .|.|.|   |.|:|.::|.:|:|.|..:....:.:.|....   |:  :::|.:
  Rat   320 LLETGVWVD--AAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTV 382

  Fly   321 VSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQLF 385
            :.:|.|...:|:|:..   :.....:||::.|.|:..:.....:..|::.||:...|......|.
  Rat   383 LGYMAEMRNEDVSEVA---KDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLE 444

  Fly   386 TVLQSLFDEFEKLKERKQE---VTFGIICGLAICSFFFCTEHGSFYFAILGIDVILAHSLLHLLL 447
            .|:.::.|||..:..:::|   :...|.|.|.  |....|..|::...:|. :.....::|.:.|
  Rat   445 GVITAVLDEFPHIWAKRREWFVLIVVITCVLG--SLLTLTSGGAYVVTLLE-EYATGPAVLTVAL 506

  Fly   448 L--LVVLWIYGQKRFQRDIEFMLG-QPFASWKV--------FILRYTAPIVFLICMILGIIECIR 501
            :  :.|.|.||..:|..|::.||| .|...|::        |:|       |:||..|.....:|
  Rat   507 IEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLL-------FIICSFLMSPPQLR 564

  Fly   502 V-HFFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRPTDWYPVEMKHRQHYG 565
            : .:.:....:|||..:.:...:.||.|..|.|..:|||..||:.:|..|..  |.|:.
  Rat   565 LFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPET--PTEIP------ 621

  Fly   566 DRVGNIEM 573
              .|:|.|
  Rat   622 --CGDIRM 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	127/505 (25%)
Slc6a4	NP_037166.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..60
		5HT_transport_N	24..64	CDD:397524
		SLC6sbd_SERT	79..615	CDD:271399	145/568 (26%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624		2/17 (12%)