DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and Slc6a2

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus

Alignment Length:	565	Identity:	139/565 - (24%)
Similarity:	249/565 - (44%)	Gaps:	60/565 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            |..|.|..|:|.:..|.|:.| :::...|..:.|.|...::||.|:::|..:|:..:...:||::
Mouse    56 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN 120

  Fly    84 SSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPWSCEGLKSWH--N 146
            ..|....:::.|.|||:||..|.:......||::.:|..|.:|..||...|||:..| .||:  |
Mouse   121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCG-HSWNSPN 184

  Fly   147 RTDEYPTLCHPTIYKQHENYTLGVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLSWALIAI 211
            .||  |.|.:.::...|..|:.....|:..:::........:....||..|...|......:|.:
Mouse   185 CTD--PKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVV 247

  Fly   212 IFYHFSEPAK-FGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYITPNTKDFSEGIYSTFI- 274
            :::...:..| .||.:.........::.|..|..:.|||:...:..|:..:.....|.  :.:|
Mouse   248 LYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEA--TVWID 310

  Fly   275 MALQAF---GAGWGSVIALSSFNGFKTD-------IMSYSWIISFGQIFIYIMFGLVSFMLEQYY 329
            .|.|.|   |||:|.:||.:|:|.|..:       ..:.:.:.||  |..:.:|.::.:|..::.
Mouse   311 AATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSF--ISGFAIFSILGYMAHEHK 373

  Fly   330 KDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIYYSMLLLASLTVIATQLFTVLQSLFDE 394
            .:|.|...    ....::|:....|::||.....|..:::.|||...|......:..|:..|.|:
Mouse   374 VNIEDVAT----EGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADD 434

  Fly   395 FEKLKERKQEVTFGIICGLAICSF---FFCTEHGSFYFAILGIDVILA-HSLLHLLLL--LVVLW 453
            |:.||..::..|    |.:.|.:|   .||...|..|...| :|...| .|:|..:|:  :.|.|
Mouse   435 FQVLKRHRKLFT----CVVTISTFLLALFCITKGGIYVLTL-LDTFAAGTSILFAVLMEAIGVSW 494

  Fly   454 IYGQKRFQRDIEFMLG-QPFASWKVFILRYTAPIVFLICMILGIIECIRVHFFFKEV-------- 509
            .||..||..||:.|:| :|...|:: ..::.:|...|..:::.||.       ||.:
Mouse   495 FYGVDRFSNDIQQMMGFKPGLYWRL-CWKFVSPAFLLFVVVVSIIN-------FKPLTYDDYTYP 551

  Fly   510 ----FLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRP 550
                ::..||.|..:  :.:|.|..|......|:..||:.....|
Mouse   552 PWANWVGWGIALSSM--ILVPAYVIYKFLSIRGSLWERVAYGITP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	122/490 (25%)
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	139/565 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810