DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and Slc6a13

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001366036.1	Gene:	Slc6a13 / 14412	MGIID:	95629	Length:	602	Species:	Mus musculus

Alignment Length:	609	Identity:	143/609 - (23%)
Similarity:	256/609 - (42%)	Gaps:	99/609 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ASG------TKPFSP---------DPKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFV 56
            |||      |||..|         ..:|..|....:::.:..|..:.| :::...|..:.|.|..
Mouse     5 ASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGA 69

  Fly    57 GMLPYFLYMVIYLVPILVVHSFMGQFSSSGFIAAF-RLAPLFKGMGYVSIFLTFTTLIYYSMFVA 120
            ..:||.:::....:|:..:.:.:||:::.|.|.|: |:.|:|:|:||.|..:.....:||.:.:|
Mouse    70 FFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLA 134

  Fly   121 IPLLFLINSFRPTLPW-SCEGLKSWHNRTDEYPTLCHPTIYKQHENYTLGV---EAPSRLYFDYI 181
            ..|.:|.:||...||| ||.  ..|:...      |   :..|..|.::.|   .|.|.:...:.
Mouse   135 WALFYLFSSFTTDLPWGSCS--HEWNTEN------C---VEFQKANDSMNVTSENATSPVIEFWE 188

  Fly   182 RQDYFNTDKRFDISRPLIGLFTLSWALIA------IIFYH--FSEPAKFGKCIRYMVITTMVLVV 238
            |       :...:|..:..|.:|.|.|:.      ||.|.  :......||.:.:......:::|
Mouse   189 R-------RVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLV 246

  Fly   239 VCFVRFLFLPGSHKLLWMYITPNT---------KDFSEGIYSTFIMALQAFGAGWGSVIALSSFN 294
            |..:|.:.|||:.:.:..|:.||.         .|....|:.:|.:.|       |.:.||.|:|
Mouse   247 VLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICL-------GCLTALGSYN 304

  Fly   295 GFKTD---------IMSYSWIISFGQIFIYIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLS 350
            .:..:         |::.|.....|    :.:|.::.||.::....||:...    ....:.|::
Mouse   305 KYHNNCYRDCIALCILNSSTSFMAG----FAIFSILGFMSQEQGVPISEVAE----SGPGLAFIA 361

  Fly   351 SASALNTLGWPNLWTFIYYSMLLLASLT---VIATQLFTVLQSLFDEFEKLKERKQEVTFGIICG 412
            ...|:..|.:..||...::.|::|..|.   |....|.|.|..::....:.|.|::.    :|..
Mouse   362 YPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREV----LILI 422

  Fly   413 LAICSFF----FCTEHGSFYFAILGIDVILAHSLLHLLLL--LVVLWIYGQKRFQRDIEFMLG-Q 470
            :::.|||    ..||.|.:.|.:..........||.:.:.  |.|.|:||..||..:||.|:| :
Mouse   423 VSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYK 487

  Fly   471 PFASWKVFILRYTAPIVFLICMILGIIECIRVHFFFKEVFL----VLGIILVVLPFLAIPGYGFY 531
            |:...|...|.:| |.|.|...:..:|:...:.:..|..:.    .||.:|.:...:.||.:..|
Mouse   488 PWPLIKYCWLFFT-PAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIY 551

  Fly   532 YLRQSPGTFLERLKRSCRPTDWYP 555
            .||...|...|||::...|.:..|
Mouse   552 KLRTLKGPLRERLRQLVCPAEDLP 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	118/510 (23%)
Slc6a13	NP_001366036.1	SLC5-6-like_sbd	32..575	CDD:382020	135/580 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000