Protein Alignment CG33296 and Slc6a3

DIOPT Version :10

• Sequence 1: NP_995644.2
• Gene: CG33296 / 2768941
• FlyBaseID: FBgn0053296
• Length: 585
• Species: Drosophila melanogaster
• Sequence 2: NP_034150.1
• Gene: Slc6a3 / 13162
• MGIID: 94862
• Length: 619
• Species: Mus musculus
• Alignment Length: 581
• Identity: 143/581 - (24%)
• Similarity: 251/581 - (43%)
• Gaps: 92/581 - (15%)

  Fly    19 KRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQF 82
            :|..|.|..|:|.:..|.|:.| :::...|..:.|.|...::||.|:|||..:|:..:...:|||
Mouse    59 ERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQF 123

  Fly    83 SSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPW-SCEGLKSWHN 146
            :..|....:::.|:.||:|:..|.::|....:|::.:|..|.:..:||...||| .|.  .:|::
Mouse   124 NREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCN--NTWNS 186

  Fly   147 RTDEYPTLCHPTIYKQHE---------NYTLGVEAPSRLYFD----YIRQDYFNTDKRFDISRPL 198
                      |.....|.         |.|.|. .|:..||:    ::.|           ||.:
Mouse   187 ----------PNCSDAHSSNSSDGLGLNDTFGT-TPAAEYFERGVLHLHQ-----------SRGI 229

  Fly   199 IGLFTLSWALIA-----IIFYHFS--EPAK-FGKCI------RYMVITTMVLVVVCFVRFLFLPG 249
            ..|....|.|.|     |:..:||  :..| .||.:      .|:|:|.::|      |.:.|||
Mouse   230 DDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLL------RGVTLPG 288

  Fly   250 SHKLLWMYITPNTKDFSEGIYSTFIMALQ----AFGAGWGSVIALSSFNGFKTD-------IMSY 303
            :...:..|::.:.....|.  |.:|.|..    :.|.|:|.:||.||:|.|..:       ..|.
Mouse   289 AMDGIRAYLSVDFYRLCEA--SVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSI 351

  Fly   304 SWIISFGQIFIYIMFGLVSFMLEQYYKDISDTIVFHRIMNFWVLFLSSASALNTLGWPNLWTFIY 368
            :.:.||...|  ::|..:.:|.:::...|.|...    ....::|:....|:.||...:.|..::
Mouse   352 NSLTSFSSGF--VVFSFLGYMAQKHNVPIRDVAT----DGPGLIFIIYPEAIATLPLSSAWAAVF 410

  Fly   369 YSMLLLASLTVIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLAICSFFFCTEHGSFYFAIL- 432
            :.|||...:......:.:|:..|.|||:.|...::..|.||:....:.|.|..|..|.:.|.:|
Mouse   411 FLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLD 475

  Fly   433 ----GIDVILAHSLLHLLLLLVVLWIYGQKRFQRDIEFMLGQ-PFASWKVFILRYTAPIVFLICM 492
                |..::..    .|:..:.|.|.||.::|..||:.|.|| |...|:: ..:..:|...|..:
Mouse   476 HFAAGTSILFG----VLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRL-CWKLVSPCFLLYVV 535

  Fly   493 ILGIIECIRVH---FFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGTFLERLKRSCRP 550
            ::.|:.....|   :.|.:....||.|:.......:|.|..|.....||:|.|:|..:..|
Mouse   536 VVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITP 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_995644.2	SLC5-6-like_sbd	27..496	CDD:271356	125/514 (24%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:444915	143/580 (25%)
		Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		8/28 (29%)