DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33296 and Slc6a7

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	602	Identity:	152/602 - (25%)
Similarity:	262/602 - (43%)	Gaps:	89/602 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KPFSPD------------------PKRGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVG 57
            ||.:||                  ..||.|....|:|.:|.|..:.| :::...|..:.|.|...
  Rat    11 KPVTPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAF 75

  Fly    58 MLPYFLYMVIYLVPILVVHSFMGQFSSSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIP 122
            ::||||.:.|..:|:..:...:|||||.|.:|.::::|||||.|...:.:.....|||:|.:|..
  Rat    76 LVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYV 140

  Fly   123 LLFLINSFRPTLPWSCEGLKSWHN--RTDEY----------PTLCHPTI---------YKQHENY 166
            |.:|..|....|||  |...:|.|  |..|:          |.....|:         |..|...
  Rat   141 LFYLFASLTSNLPW--EHCGNWWNTERCLEHRGPKDGNGALPLNLSSTVSPSEEYWSRYVLHIQG 203

  Fly   167 TLGVEAPSRLYFDYIRQDYFNTDKRFDISRPLIGLFTLSWALIAIIFYHFSEPAK-FGKCIRYMV 230
            :.|:..|..:              |:::...|:    |:|   .|:|....:..| .||.:.:..
  Rat   204 SQGIGRPGEI--------------RWNLCLCLL----LAW---VIVFLCILKGVKSSGKVVYFTA 247

  Fly   231 ITTMVLVVVCFVRFLFLPGSHKLLWMYITP------NTKDFSEGIYSTFIMALQAF---GAGWGS 286
            ....:::::..||.:.|||:.|.:..|:||      ::|.:.|.       |||.|   |.|:|.
  Rat   248 TFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEA-------ALQIFYSLGVGFGG 305

  Fly   287 VIALSSFNGFKTDIMSYSWIISFGQIFIYIMFGLVSFMLEQYY-KDISDTIVFHRIMNFWVLFLS 350
            ::..:|:|.|..:|...::|::.|.....|:.|...|.:..|. :::...:.........:.|:.
  Rat   306 LLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVV 370

  Fly   351 SASALNTLGWPNLWTFIYYSMLLLASLTVIATQLFTVLQSLFDEFEKLKERKQEVTFGIICGLAI 415
            ...|:..|.....|:|:::.|||...|......|.|::.::.|||......|:.|..|:||....
  Rat   371 YPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAMY 435

  Fly   416 CSFFFCTEHGSFYFAILGIDVILAHSLLHLLL--LLVVLWIYGQKRFQRDIEFMLG-QPFASWKV 477
            ......|..|..|:.:|..|...:..|:.:::  .|.|..:||.:||.|||..||| :|...::.
  Rat   436 LMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYFRA 500

  Fly   478 FILRYTAPIVFLICMILGIIECIRVH---FFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPGT 539
            ..| :.:|...|..::..|::.....   :.|.....:|||::.:|..|.||......:.:..|:
  Rat   501 CWL-FLSPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEGS 564

  Fly   540 FLERLKRSCRPT-DWYP 555
            ..|||:::.||. ||.|
  Rat   565 LWERLQQASRPAIDWGP 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	127/504 (25%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	147/574 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810