DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33296 and Slc6a9

DIOPT Version :9

Sequence 1:	NP_001285711.1	Gene:	CG33296 / 2768941	FlyBaseID:	FBgn0053296	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	XP_006238687.1	Gene:	Slc6a9 / 116509	RGDID:	621243	Length:	638	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	145/588 - (24%)
Similarity:	272/588 - (46%)	Gaps:	71/588 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RGKWEKPTDYLFACFGLALKL-DIFEVSYWFFFNIGFVGMLPYFLYMVIYLVPILVVHSFMGQFS 83
            ||.|....:::....|.|:.| :::...|..:.|.|...|.|||:.:|...:|:..:....|||:
  Rat    32 RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGGGAFMFPYFIMLVFCGIPLFFMELSFGQFA 96

  Fly    84 SSGFIAAFRLAPLFKGMGYVSIFLTFTTLIYYSMFVAIPLLFLINSFRPTLPWS----------C 138
            |.|.:..:|::|:|||:||..:.::....|||::.:.|...:..:|....|||:          |
  Rat    97 SQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTPDC 161

  Fly   139 EGLKSWHNRTD-EYPT-----LCHPTIYKQHENYTLGVEAPS----RLYFDYIRQDYFNTDKRFD 193
            .|:....|.|: ..||     |.|  ::    ||||...:||    |||...:..|..:..   :
  Rat   162 AGVLDASNLTNGSRPTALSGNLSH--LF----NYTLQRTSPSEEYWRLYVLKLSDDIGDFG---E 217

  Fly   194 ISRPLIGLFTLSWALIAIIFYHFSEPAKFGKCIRYMVITTMVLVVVCFVRFLFLPGSHKLLWMYI 258
            :..||:|...:||.::.:......:.:  ||.:.:......|::.:.|||.:.|.|:...:..|:
  Rat   218 VRLPLLGCLGVSWVVVFLCLIRGVKSS--GKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYL 280

  Fly   259 TP------NTKDFSEGIYSTFIMALQAFGAGWGSVIALSSFNGFKTDIMSYSWIISFGQIFI--- 314
            ||      ..|.:.:.....|    .:.|..||.:|.::|:|.|..:....|.|||......
  Rat   281 TPKWDKILEAKVWGDAASQIF----YSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVY 341

  Fly   315 --YIMFGLVSFMLEQYYKDISDTIVFHRIMNF--WVLFLSSASALNTLGWPNLWTFIYYSMLLLA 375
              :::|.::.||......|:|      |:.:.  .:.|::...||..|....||:.:::.||:|.
  Rat   342 AGFVIFSILGFMANHLGVDVS------RVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILL 400

  Fly   376 SLTVIATQLFTVLQSLFDEF--EKLKERKQEVTFGIICGLAICSFFF---CTEHGSFYFAILGID 435
            .|......|.|::.::.||.  |.:.::|..||.|:    |:..|..   .|.....|:.:|..:
  Rat   401 GLGTQFCLLETLVTAIVDEVGNEWILQKKTYVTLGV----AVAGFLLGIPLTSQAGIYWLLLMDN 461

  Fly   436 VILAHSL--LHLLLLLVVLWIYGQKRFQRDIEFMLGQPFASWKVFILRYTAPIVFLICMILGIIE 498
            ...:.||  :..::.:.:::|||.:.:.:||:.|||.|...:.....|:.:|.:....:|..:|:
  Rat   462 YAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPTIIFFILIFTVIQ 526

  Fly   499 CIRV---HFFFKEVFLVLGIILVVLPFLAIPGYGFYYLRQSPG-TFLERLKRSCRPT-DWYPVEM 558
            ...:   |:.:....:.:|.::.:...:.||.|..:.|.::.| |.|:|||.:.:|: ||.|..:
  Rat   527 YRPITYNHYQYPGWAVAIGFLMALSSVICIPLYALFQLCRTDGDTLLQRLKNATKPSRDWGPALL 591

  Fly   559 KHR 561
            :||
  Rat   592 EHR 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33296	NP_001285711.1	SLC5-6-like_sbd	27..496	CDD:271356	123/509 (24%)
Slc6a9	XP_006238687.1	SLC6sbd_GlyT1	16..599	CDD:212067	145/588 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810