DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp2A-29B and PP2AA3

DIOPT Version :9

Sequence 1:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001184981.1	Gene:	PP2AA3 / 837892	AraportID:	AT1G13320	Length:	587	Species:	Arabidopsis thaliana

Alignment Length:	582	Identity:	331/582 - (56%)
Similarity:	425/582 - (73%)	Gaps:	6/582 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDEDEVLLALA 72
            ||:.|||||||||||||:|:|.||||||:||.||.||||||||.||||||:|...|:||||||:|
plant     4 VDEPLYPIAVLIDELKNDDIQRRLNSIKRLSIIARALGEERTRKELIPFLSENNDDDDEVLLAMA 68

  Fly    73 DQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHVVPTLQRL 137
            ::||.|...|||.|:|..|:||||:|:|||||.||:|||:||..:.|:....||..|..|..:||
plant    69 EELGGFILYVGGVEYAYVLLPPLETLSTVEETCVREKAVDSLCRIGAQMRESDLVEHFTPLAKRL 133

  Fly   138 VSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFAKVVETEY 202
            .:|:|||:|.||||:|.:.||.....:|.|||:.:.:||||:.||||||||..||:||..:|:.:
plant   134 SAGEWFTARVSACGIFHIAYPSAPDVLKTELRSIYGQLCQDDMPMVRRAAATNLGKFAATIESAH 198

  Fly   203 LKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLL-PQDDVEHLVLPTLRQCASDSSWRVRYMVA 266
            ||:|::..|..|.|||||||||||||.|.::.:|| |||.|.| :||.:...:.|.|||||||||
plant   199 LKTDIMSMFEDLTQDDQDSVRLLAVEGCAALGKLLEPQDCVAH-ILPVIVNFSQDKSWRVRYMVA 262

  Fly   267 EKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIILSSILPY 331
            .:..:|.:|||||.||.|||||:..||.|.|||||.|.|.||..||    ::...::.:..|||.
plant   263 NQLYELCEAVGPEPTRTDLVPAYARLLCDNEAEVRIAAAGKVTKFC----RILNPELAIQHILPC 323

  Fly   332 VRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDV 396
            |::|.||.:.||:|||||||||::|:||...|:|.|||:||..||||.|:|||||||.||.||.|
plant   324 VKELSSDSSQHVRSALASVIMGMAPVLGKDATIEHLLPIFLSLLKDEFPDVRLNIISKLDQVNQV 388

  Fly   397 IGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLNDHVYAIR 461
            |||..|||||||||||||||..||||||||||:|.||.|||..|||:||..|||.||.|.|::||
plant   389 IGIDLLSQSLLPAIVELAEDRHWRVRLAIIEYIPLLASQLGVGFFDEKLGALCMQWLQDKVHSIR 453

  Fly   462 EAATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPT 526
            |||..|:|:|.|:||..||.|.|:|.:|.|..|.:||:|||.|..:::||.|.|::||...|||.
plant   454 EAAANNLKRLAEEFGPEWAMQHIVPQVLEMINNPHYLYRMTILRAVSLLAPVMGSEITCSKLLPA 518

  Fly   527 VLLLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAIAGI 588
            |:..:.|.|.|::|||||.:|.:.|.::.:|::..::|.|.:|:.|.||||::||.||:..|
plant   519 VITASKDRVPNIKFNVAKMMQSLIPIVDQAVVENMIRPCLVELSEDPDVDVRYFANQALQSI 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	70/99 (71%)
		HEAT repeat	15..39	CDD:293787	19/23 (83%)
		HEAT repeat	53..80	CDD:293787	17/26 (65%)
		HEAT repeat	90..120	CDD:293787	18/29 (62%)
		HEAT repeat	129..154	CDD:293787	13/24 (54%)
		HEAT repeat	165..194	CDD:293787	18/28 (64%)
		HEAT_2	175..267	CDD:290374	54/92 (59%)
		HEAT_EZ	181..230	CDD:290247	31/48 (65%)
		HEAT repeat	206..232	CDD:293787	17/25 (68%)
		HEAT repeat	247..271	CDD:293787	12/23 (52%)
		HEAT repeat	285..313	CDD:293787	17/27 (63%)
		HEAT repeat	327..357	CDD:293787	18/29 (62%)
		HEAT repeat	366..392	CDD:293787	18/25 (72%)
		HEAT repeat	403..432	CDD:293787	25/28 (89%)
		HEAT repeat	444..470	CDD:293787	15/25 (60%)
		HEAT repeat	481..510	CDD:293787	12/28 (43%)
		HEAT repeat	520..546	CDD:293787	12/25 (48%)
PP2AA3	NP_001184981.1	HEAT repeat	11..35	CDD:293787	19/23 (83%)
		HEAT repeat	49..76	CDD:293787	17/26 (65%)
		HEAT repeat	91..112	CDD:293787	15/20 (75%)
		HEAT repeat	126..153	CDD:293787	13/26 (50%)
		HEAT repeat	163..193	CDD:293787	19/29 (66%)
		HEAT	193..>419	CDD:224331	136/230 (59%)
		HEAT repeat	202..228	CDD:293787	17/25 (68%)
		Vac14_Fab1_bd	220..300	CDD:289521	46/80 (58%)
		HEAT repeat	243..267	CDD:293787	12/23 (52%)
		HEAT repeat	281..309	CDD:293787	18/31 (58%)
		HEAT repeat	319..349	CDD:293787	18/29 (62%)
		HEAT_2	356..461	CDD:290374	75/104 (72%)
		HEAT repeat	358..384	CDD:293787	18/25 (72%)
		HEAT repeat	395..424	CDD:293787	25/28 (89%)
		HEAT repeat	436..462	CDD:293787	15/25 (60%)
		HEAT repeat	473..502	CDD:293787	12/28 (43%)
		HEAT repeat	512..536	CDD:293787	10/23 (43%)
		HEAT repeat	551..577	CDD:293787	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	201	1.000	Domainoid score	I868
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	634	1.000	Inparanoid score	I192
OMA	1	1.010	-	-		QHG54034
OrthoDB	1	1.010	-	-		D447572at2759
OrthoFinder	1	1.000	-	-		FOG0001701
OrthoInspector	1	1.000	-	-		otm2832
orthoMCL	1	0.900	-	-		OOG6_101100
Panther	1	1.100	-	-	O	PTHR10648
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1096
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840