DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp2A-29B and Ppp4r4

DIOPT Version :9

Sequence 1:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	XP_006516371.1	Gene:	Ppp4r4 / 74521	MGIID:	1921771	Length:	880	Species:	Mus musculus

Alignment Length:	709	Identity:	140/709 - (19%)
Similarity:	261/709 - (36%)	Gaps:	189/709 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DELKNEDVQLRLNSIKKLSTIALALGEERTRSELI---PFL-----TETI-----------YDED 65
            :|::...|...|:.|.: :...|:.|::...:.:|   |||     |||:           |:|
Mouse    44 EEIERLTVDEDLSDIDR-AVYLLSAGQDVQGASVIANLPFLMRQNPTETLRRVLPKVRVSWYEE- 106

  Fly    66 EVLLALADQLGNFTSLVG---------------GPEFAMYLIPPLESLATVEETVVRDKAVESLR 115
              :|.:|......|:.|.               ...|...::..||.    .:|.|.:..:|:|.
Mouse   107 --VLHVASVEMQLTAAVSFLTILQEESMSVHTCAHSFLQVILLHLEH----RDTGVSNAWLETLL 165

  Fly   116 TVAAEHSAQDLEIHVV--PTLQRLVSGDWFTSRTSACGLFSVCYPRVT-----QPVKAELRANFR 173
            : |.|...::...|.:  |.:.:........||..:|.:..    ::|     ..:|.|:....:
Mouse   166 S-AVELLPKETLRHEILNPLVSKAQLSQTVQSRLVSCKILG----KITNKFDAHSIKREILPLVK 225

  Fly   174 KLCQDETPMVRRAAANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLP 238
            .||||....||.....:|...|:.:..|..|:.::|..::|::|:..||||.|.|..|::..:..
Mouse   226 SLCQDVEYEVRSCMCRQLENIAQGIGAELTKNVVLPELIELSRDESGSVRLAAFETLVNMLDMFD 290

  Fly   239 QDDVEHLVLPTLRQCASDS----------------------------SWRVRYMVAEK---FVDL 272
            .||....:||.::.....|                            ...:|::...|   .:.|
Mouse   291 TDDRSQTILPLVKSFCEKSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGL 355

  Fly   273 QKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVA------TKVKDFCAN--------LDKVNQVQI 323
            |:..|..                 |:::.:.:.      |.|:..||.        :|..|....
Mouse   356 QQENGHN-----------------ESQIPSQIVEQEKKYTSVRKNCAYNFPAMIVFVDPKNFHME 403

  Fly   324 ILSSILPYVRDLVSDPNPHVKSALASVIMGLSPML--GAYQTVEQLLPLFLIQLKDECPEVRLNI 386
            :.|:..    .|..||...|:..:|.....:|.:|  |.:...::|:.|    |:||..||...:
Mouse   404 LYSTFF----CLCHDPEVPVRHTIAICFYEVSKLLNSGVHLIHKELITL----LQDESLEVLDAL 460

  Fly   387 ISNLDCVNDVI------GIQQLSQS----LLPAIV----ELAEDSKWRVRLAIIEYMPAL----- 432
            |::|..:.:::      .:|:...|    |:||:.    ..|...|||....:::....|
Mouse   461 INHLPEILELMSTGGENSVQENKFSSVPDLIPALTAAEQRAAASLKWRTHEKLLQKYTCLPHIIS 525

  Fly   433 AGQLGQEFFDQKLRGLCMGWLNDHVYAIREAATLNM-----------------KKLVEQFGAPWA 480
            :.|:...|. |::..:.|   .::|..::.||...:                 :||:||.|
Mouse   526 SDQIYYRFL-QRMFTIMM---TNNVLPVQRAAARTLCIFLRYNRKQEQRHEVIQKLIEQLG---- 582

  Fly   481 EQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVLLLAADPVANVRFNVAKT 545
                        :.|:|.:|:..|.....:.|:.......|.....|:.|..|||||||..:...
Mouse   583 ------------QGKSYWNRLRFLDTCEFIIEIFSRSFFCKYFFLPVIELTHDPVANVRMKLCYL 635

  Fly   546 LQKISPFLEASVIDAQVKPTLDK-----LNTDTDVDVKHFAAQAIAGI-AAEMELNVFR 598
            |.|:...|:... |..:...|:.     |..:.|.||.....:.:..: ..||.:::|:
Mouse   636 LPKVKSALKIPA-DMHLLQQLEMCVRKLLCQEKDKDVLAIVKKTVLELDRMEMSMDMFQ 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	25/128 (20%)
		HEAT repeat	15..39	CDD:293787	4/18 (22%)
		HEAT repeat	53..80	CDD:293787	11/45 (24%)
		HEAT repeat	90..120	CDD:293787	7/29 (24%)
		HEAT repeat	129..154	CDD:293787	5/26 (19%)
		HEAT repeat	165..194	CDD:293787	9/28 (32%)
		HEAT_2	175..267	CDD:290374	26/119 (22%)
		HEAT_EZ	181..230	CDD:290247	15/48 (31%)
		HEAT repeat	206..232	CDD:293787	9/25 (36%)
		HEAT repeat	247..271	CDD:293787	5/54 (9%)
		HEAT repeat	285..313	CDD:293787	3/33 (9%)
		HEAT repeat	327..357	CDD:293787	6/29 (21%)
		HEAT repeat	366..392	CDD:293787	9/25 (36%)
		HEAT repeat	403..432	CDD:293787	8/36 (22%)
		HEAT repeat	444..470	CDD:293787	4/42 (10%)
		HEAT repeat	481..510	CDD:293787	4/28 (14%)
		HEAT repeat	520..546	CDD:293787	10/25 (40%)
Ppp4r4	XP_006516371.1	HEAT repeat	141..169	CDD:293787	8/32 (25%)
		HEAT repeat	219..249	CDD:293787	9/29 (31%)
		HEAT repeat	258..284	CDD:293787	9/25 (36%)
		HEAT repeat	441..469	CDD:293787	9/31 (29%)
		HEAT repeat	485..513	CDD:293787	8/27 (30%)
		HEAT repeat	522..560	CDD:293787	7/41 (17%)
		HEAT repeat	571..603	CDD:293787	9/47 (19%)
		PTZ00108	<655..880	CDD:240271	8/39 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D447572at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820