DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pp2A-29B and PPP4R4

DIOPT Version :10

Sequence 1:NP_001245944.1 Gene:Pp2A-29B / 2768940 FlyBaseID:FBgn0260439 Length:650 Species:Drosophila melanogaster
Sequence 2:NP_478144.1 Gene:PPP4R4 / 57718 HGNCID:23788 Length:873 Species:Homo sapiens


Alignment Length:695 Identity:141/695 - (20%)
Similarity:257/695 - (36%) Gaps:166/695 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 DELKNEDVQLRLNSIKKLSTIALALGEERTRSELI---PFL-----TETIYDEDEVLLALADQLG 76
            :|::...|...|:.|:: :...|:.|::...:.:|   |||     |||:   ..||..:.:.|.
Human    42 EEIERLTVDEDLSDIER-AVYLLSAGQDVQGTSVIANLPFLMRQNPTETL---RRVLPKVREALH 102

  Fly    77 NFTSLVGGPEFAMYLIPPLESLATVEETVV-------------------RDKAV-----ESLRTV 117
                 |.|.|  |.|...:..|..:::..|                   ||..|     |:|.:|
Human   103 -----VAGVE--MQLTAAMSFLTILQDESVSIHAYTHSFLQVILLHLEHRDTGVSNAWLETLLSV 160

  Fly   118 AAEHSAQDLEIHVV-PTLQRLVSGDWFTSRTSACGLFSVCYPRVT-----QPVKAELRANFRKLC 176
            ......:.|...:: |.:.:........||..:|.:..    ::|     ..:|.|:....:.||
Human   161 IEVLPKETLRHEILNPLVSKAQLSQTVQSRLVSCKILG----KLTNKFDAHTIKREILPLVKSLC 221

  Fly   177 QDETPMVRRAAANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDD 241
            ||....||.....:|...|:.:.||..||.::|..::|::|:..||||.|.|..|::..:...||
Human   222 QDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDD 286

  Fly   242 VEHLVLPTLRQCASDS----------------------------SWRVRYMVAEK---FVDLQKA 275
            ....:||.::.....|                            ...:|::...|   .:.||:.
Human   287 RSQTILPLVKSFCEKSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQE 351

  Fly   276 VG-------PEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIILSSILPYVR 333
            .|       |:|    |....:|:      .||...|.........:|..|....:.|:..    
Human   352 NGHNENQIPPQI----LEQEKKYI------SVRKNCAYNFPAMIVFVDPKNFHMELYSTFF---- 402

  Fly   334 DLVSDPNPHVKSALASVIMGLSPML--GAYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDV 396
            .|..||...|:..:|.....:|.:|  |.|...::|:.|    |:||..||...:|.:|..:.::
Human   403 CLCHDPEVPVRYTIAICFYEVSKLLNSGVYLIHKELITL----LQDESLEVLDALIDHLPEILEL 463

  Fly   397 I------GIQQLSQSLLPAIV--------ELAEDSKWRVRLAIIEYMPALAGQL-GQEFFDQKLR 446
            :      .:|:...|.||.::        ..|...|||....:::....|...: ..:.:.:.|:
Human   464 MSTGGESSVQENKLSSLPDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQ 528

  Fly   447 GLCMGWLNDHVYAIREAATLNM-----------------KKLVEQFGAPWAEQAIIPMILVMSRN 494
            .:....:.::|..:::||:..:                 :||:||.|                :.
Human   529 RMFTIMMTNNVLPVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLG----------------QG 577

  Fly   495 KNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVLLLAADPVANVRFNVAKTLQKISPFLEASVID 559
            |:|.:|:..|.....:.|:.......|......:.|..|||||||..:...|.|:...|:... |
Human   578 KSYWNRLRFLDTCEFIIEIFSKSFFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPA-D 641

  Fly   560 AQVKPTLDK-----LNTDTDVDVKHFAAQAIAGI-AAEMELNVFR 598
            ..:...|:.     |..:.|.||.....:.:..: ..||.::.|:
Human   642 KHLLQQLEMCVRKLLCQEKDKDVLAIVKRTVLELDRMEMSMDAFQ 686

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pp2A-29BNP_001245944.1 HEAT repeat 15..39 CDD:293787 4/18 (22%)
HEAT repeat 53..80 CDD:293787 10/34 (29%)
HEAT repeat 90..120 CDD:293787 9/53 (17%)
HEAT repeat 129..154 CDD:293787 4/25 (16%)
HEAT repeat 165..194 CDD:293787 9/28 (32%)
HEAT_2 175..267 CDD:433376 28/119 (24%)
HEAT repeat 206..232 CDD:293787 9/25 (36%)
HEAT repeat 247..271 CDD:293787 5/54 (9%)
HEAT repeat 285..313 CDD:293787 5/27 (19%)
HEAT <327..427 CDD:441023 26/115 (23%)
HEAT repeat 327..357 CDD:293787 6/29 (21%)
HEAT repeat 366..392 CDD:293787 9/25 (36%)
HEAT repeat 403..432 CDD:293787 7/36 (19%)
HEAT repeat 444..470 CDD:293787 4/42 (10%)
HEAT repeat 481..510 CDD:293787 4/28 (14%)
HEAT repeat 520..546 CDD:293787 9/25 (36%)
PPP4R4NP_478144.1 HEAT repeat 135..159 CDD:293787 5/23 (22%)
HEAT repeat 173..202 CDD:293787 4/32 (13%)
HEAT-like repeat region 205..243 10/37 (27%)
HEAT repeat 212..242 CDD:293787 9/29 (31%)
HEAT 1 213..251 11/37 (30%)
HEAT-like repeat region 244..282 14/37 (38%)
HEAT repeat 251..277 CDD:293787 9/25 (36%)
HEAT 2 252..290 12/37 (32%)
HEAT 3 392..427 8/38 (21%)
HEAT repeat 396..422 CDD:293787 6/29 (21%)
HEAT repeat 433..460 CDD:293787 9/30 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..766
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..873
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.