DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp2A-29B and RELCH

DIOPT Version :9

Sequence 1:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_001333158.1	Gene:	RELCH / 57614	HGNCID:	29289	Length:	1250	Species:	Homo sapiens

Alignment Length:	847	Identity:	160/847 - (18%)
Similarity:	284/847 - (33%)	Gaps:	244/847 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SVDDSLYPIAVLIDELKNEDVQLRL--------------NSIKKLSTIAL---ALGEERT----- 49
            |.|...:|.....|:.||.|:.|.:              ||..:.....:   :|..::|
Human   416 SEDSGQHPDVNSSDKGKNTDIHLSISDEADSTIPKENSPNSFPRREREGMPPSSLSSKKTVHFDK 480

  Fly    50 -RSELIPFLTETIYDEDEVLLAL----AD-QLGNFTSLVGGPEFAMYL--------IPPLESLAT 100
             ..:|.|..       .:.||:.    || :||...|.:...|.::.|        |.|...||.
Human   481 PNRKLSPAF-------HQALLSFCRMSADSRLGYEVSRIADSEKSVMLMLGRCLPHIVPNVLLAK 538

  Fly   101 VEETVVRDKAVESLRTVAAEHSAQDLEIHVVPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQP-- 163
            .||.:   ..:.....:..|...:|..:|::..|.:....:......:.|    |.:.|...|
Human   539 REELI---PLILCTACLHPEPKERDQLLHILFNLIKRPDDEQRQMILTGC----VAFARHVGPTR 596

  Fly   164 VKAELRANFRKLCQDETPMVRRAAANKLGEFAKVVETEYLKSDLIPNFVQ--LAQDDQDSVRLLA 226
            |:|||.....:....:.|..|...|...|..|..:..| ::|.|:.:.:|  |.:|..|.||...
Human   597 VEAELLPQCWEQINHKYPERRLLVAESCGALAPYLPKE-IRSSLVLSMLQQMLMEDKADLVREAV 660

  Fly   227 VEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWRVRYMVAEKFVDLQKAVGPEITRVD------L 285
            :::...|...:...|..|.....|.....|.|.||.....:.|:....|...|:..:.      |
Human   661 IKSLGIIMGYIDDPDKYHQGFELLLSALGDPSERVVSATHQVFLPAYAAWTTELGNLQSHLILTL 725

  Fly   286 VPAFQYLLKDAEAEVRAAVATKVKDFCANLD--KVNQVQIILSSILPYVRDLVSDPNPHVKSAL- 347
            :...:.||::.|               ..||  |::.....|.|::|.:..||....|....|.
Human   726 LNKIEKLLREGE---------------HGLDEHKLHMYLSALQSLIPSLFALVLQNAPFSSKAKL 775

  Fly   348 ---------------ASVIMGLSPMLGAYQTVEQLLPLFLIQLKDE---------------CPEV 382
                           .|.:..:|.::|:.:.:..||.|:..||:.|               .|::
Human   776 HGEVPQIEVTRFPRPMSPLQDVSTIIGSREQLAVLLQLYDYQLEQEGTTGWESLLWVVNQLLPQL 840

  Fly   383 -----RLNIISNLDCVND----------VIG--------------IQQLSQS----------LLP 408
                 ::|:.|.. ||::          ..|              |.:||:.          |..
Human   841 IEIVGKINVTSTA-CVHEFSRFFWRLCRTFGKIFTNTKVKPQFQEILRLSEENIDSSAGNGVLTK 904

  Fly   409 AIVELAEDSKWRVRLAIIEYM-----------PAL----------AGQLGQEFFDQKLRGLCMGW 452
            |.|.:.........:.|.||:           |:|          ...|.:|  |:|   |.:|:
Human   905 ATVPIYATGVLTCYIQIKEYLHIHNEISWEWDPSLNTKCVSYTHYTHSLKEE--DRK---LLVGF 964

  Fly   453 LND--HVYAIREAATLNMKKLVEQFGA-PWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVC 514
            |.|  .:.::..|...::|....:.|| |...:.::.::.....:.:.|.|.|......:|.:..
Human   965 LEDVMTLLSLSHAPLDSLKASFVELGANPAYHELLLTVLWYGVVHTSALVRCTAARMFELLVKGV 1029

  Fly   515 GTDITTKLLLPTVLLLAADPVANVRF--------------------------------------- 540
            ...:..:.::|.::.|::||..:||.
Human  1030 NETLVAQRVVPALITLSSDPEISVRIATIPAFGTIMETVIQRELLERVKMQLASFLEDPQYQDQH 1094

  Fly   541 ----NVAKTLQKISPFLEASVIDAQVKPTLDKL---NTDTDVDVKH----------FAAQAIAGI 588
                .:.||..::.|..|....|..|.|.|.||   |....||.|.          ::|.:...|
Human  1095 SLHTEIIKTFGRVGPNAEPRFRDEFVIPHLHKLALVNNLQIVDSKRLDIATHLFEAYSALSCCFI 1159

  Fly   589 AAEMELNVFRTAIPPCMGAKIE------AAMDSKLIVEPPRQPEAADNDILQEMNGKAAEPPTLD 647
            :.::.:|.|...: .|:...:|      ..:.|.:|.|..::.|   |..:||..|..:...:|.
Human  1160 SEDLMVNHFLPGL-RCLRTDMEHLSPEHEVILSSMIKECEQKVE---NKTVQEPQGSMSIAASLV 1220

  Fly   648 SE 649
            ||
Human  1221 SE 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	26/135 (19%)
		HEAT repeat	15..39	CDD:293787	7/37 (19%)
		HEAT repeat	53..80	CDD:293787	8/31 (26%)
		HEAT repeat	90..120	CDD:293787	7/37 (19%)
		HEAT repeat	129..154	CDD:293787	3/24 (13%)
		HEAT repeat	165..194	CDD:293787	7/28 (25%)
		HEAT_2	175..267	CDD:290374	22/93 (24%)
		HEAT_EZ	181..230	CDD:290247	14/50 (28%)
		HEAT repeat	206..232	CDD:293787	7/27 (26%)
		HEAT repeat	247..271	CDD:293787	6/23 (26%)
		HEAT repeat	285..313	CDD:293787	4/27 (15%)
		HEAT repeat	327..357	CDD:293787	8/45 (18%)
		HEAT repeat	366..392	CDD:293787	9/45 (20%)
		HEAT repeat	403..432	CDD:293787	8/49 (16%)
		HEAT repeat	444..470	CDD:293787	6/27 (22%)
		HEAT repeat	481..510	CDD:293787	3/28 (11%)
		HEAT repeat	520..546	CDD:293787	7/68 (10%)
RELCH	NP_001333158.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900