DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp2A-29B and ppp4r4

DIOPT Version :9

Sequence 1:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	XP_005160668.1	Gene:	ppp4r4 / 567930	ZFINID:	ZDB-GENE-041001-164	Length:	866	Species:	Danio rerio

Alignment Length:	719	Identity:	155/719 - (21%)
Similarity:	273/719 - (37%)	Gaps:	159/719 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IDELK-NEDVQLRLNSIKKLSTIALALGEERTRSELI---PFL-----TET----IYDEDEVL-L 69
            ||:|. :||    ||.|:: :...|:.||:..|:.:|   |.|     .||    :....||| :
Zfish    40 IDKLTVDED----LNDIER-AVYLLSSGEDIQRASVIINLPILVRQNPAETFRRVVPKVREVLHV 99

  Fly    70 ALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVV---------RDKAVES--LRTVAA---- 119
            |.||.     .|.....|...|...:..:.|...:::         ||..|.|  |.|:.:
Zfish   100 AGADM-----QLAAAGSFLTILQDDIVLIQTHTHSILQIVLLNLDHRDTVVSSAWLETLLSAIDA 159

  Fly   120 ---EHSAQDLEIHVVPTLQRLVSGDWFTSRTSACGLFSVCYPRV-TQPVKAELRANFRKLCQDET 180
               |...|::   :.|.|.:........:|.::|.:......:. :..||.:|....|.||||..
Zfish   160 LPKETIRQEI---LSPLLSKHQLSQSIPARLASCRILGKVVGKFESSIVKKDLLPLIRSLCQDVE 221

  Fly   181 PMVRRAAANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHL 245
            ..||.....:|....:.:..::.|.:::|..|:||||:..:|||.|.:..:::.::...||...:
Zfish   222 YEVRACMCRQLENITRGIGLDHTKGEVLPELVELAQDEASTVRLAAFDTIINLLEMFDSDDRTCV 286

  Fly   246 VLPTLR----QC----------ASDSSWRVRYMVAEKFVDLQKAVGPEITRVDLVPAFQ------ 290
            :.|.::    :|          .|....::.:.::|.|.|.|.....|..:.......|
Zfish   287 IFPLVKAFCEKCFKGDEAVLASLSFQYGKLCHGLSESFTDEQHLWFLEFYKKLCCLGLQHENGHC 351

  Fly   291 ----YLLKDAEAEVRAAVATKVKDFCANLDKVNQVQII--------LSSILPYVRDLVSDPNPHV 343
                |.|   |.|.:.|:   |:..||    .|...|:        ||.:......|..||...|
Zfish   352 ESQPYPL---ELENKYAL---VRRNCA----YNFPAIVLFADPNHFLSELYRTFSSLCHDPEISV 406

  Fly   344 KSALASVIMGLSPMLG--AYQTVEQLLPLFLIQLKDECPEVRLNIISNLDCVNDV---------- 396
            :...|.....:..:||  .:...::|:.|    |:|:..||...:::||....::
Zfish   407 RRTAAGGFHEVVKLLGPNVHYIHKELITL----LQDDSLEVLDALLNNLQETLELATSRGEGAGP 467

  Fly   397 ----IGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPAL-----AGQLGQEFFDQKLRGLCMGW 452
                :.||.|..:|:.|..:.|....|||...:::....|     ..|:...|| |::..:..
Zfish   468 ESKQVNIQDLVPALVAAEQKAASSLHWRVHEKLLQCYSCLPRVISGDQIYFRFF-QRMFSIIT-- 529

  Fly   453 LNDHVYAIREAAT-----LNMKKLVEQFGAPWAEQAIIPMILV-MSRNKNYLHRMTCLFCLNVLA 511
            .|:.:...|||..     |...:..||      .|.|:..|.. :::.::|.:|:..|...::..
Zfish   530 TNNVLPVQREAVRTLCVFLRYNRKQEQ------RQEIMSKIKQDLAQGRSYWNRLRFLDLCDITI 588

  Fly   512 EVCGTDITTKLLLPTVLLLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVD 576
            ::.......|..|...|.|.:|||||||:.:...|.|:.         :.::||...|....:..
Zfish   589 DLFSKSYFCKHFLIPALELVSDPVANVRYKLCYMLPKLR---------STIRPTEKHLLQQLEFC 644

  Fly   577 VKHFAAQAIAGIAAEMELNVFRTAIPPCMGAKIEAAMDSKLIVEPPR---------QPEAADNDI 632
            |:..       :..|.:.:|..|.      .|....:|...|.||..         |.:..:..:
Zfish   645 VRKL-------LCREKDKDVVVTL------RKTVLELDKMDITEPYHKRHERELLDQKKEKEETL 696

  Fly   633 LQEM 636
            |.||
Zfish   697 LLEM 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	31/120 (26%)
		HEAT repeat	15..39	CDD:293787	8/20 (40%)
		HEAT repeat	53..80	CDD:293787	11/39 (28%)
		HEAT repeat	90..120	CDD:293787	8/47 (17%)
		HEAT repeat	129..154	CDD:293787	4/24 (17%)
		HEAT repeat	165..194	CDD:293787	10/28 (36%)
		HEAT_2	175..267	CDD:290374	23/105 (22%)
		HEAT_EZ	181..230	CDD:290247	14/48 (29%)
		HEAT repeat	206..232	CDD:293787	10/25 (40%)
		HEAT repeat	247..271	CDD:293787	5/37 (14%)
		HEAT repeat	285..313	CDD:293787	7/37 (19%)
		HEAT repeat	327..357	CDD:293787	5/29 (17%)
		HEAT repeat	366..392	CDD:293787	8/25 (32%)
		HEAT repeat	403..432	CDD:293787	6/28 (21%)
		HEAT repeat	444..470	CDD:293787	5/30 (17%)
		HEAT repeat	481..510	CDD:293787	6/29 (21%)
		HEAT repeat	520..546	CDD:293787	11/25 (44%)
ppp4r4	XP_005160668.1	HEAT repeat	130..158	CDD:293787	6/27 (22%)
		HEAT repeat	168..199	CDD:293787	4/33 (12%)
		HEAT repeat	208..234	CDD:293787	9/25 (36%)
		HEAT repeat	245..274	CDD:293787	11/28 (39%)
		HEAT repeat	390..420	CDD:293787	5/29 (17%)
		HEAT repeat	429..453	CDD:293787	8/27 (30%)
		HEAT repeat	474..510	CDD:293787	10/35 (29%)
		HEAT repeat	517..544	CDD:293787	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D447572at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920