DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pp2A-29B and F46C5.6

DIOPT Version :9

Sequence 1:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_495884.3	Gene:	F46C5.6 / 174413	WormBaseID:	WBGene00009781	Length:	945	Species:	Caenorhabditis elegans

Alignment Length:	630	Identity:	122/630 - (19%)
Similarity:	231/630 - (36%)	Gaps:	133/630 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETI------------YDEDEVLLALADQ 74
            ::|||:      :||...|             :..|.|.|            .:::::::.....
Worm   124 IQNEDL------VKKFQGI-------------VDLLLENILQNIQNQKEHHTQEKEKIVIKAGSS 169

  Fly    75 LGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHVVPTLQ---- 135
            :.|          .|:.:    |.|...||:|.         ||.:.|...::::|||.:|
Worm   170 INN----------QMHHL----SAAAWLETIVE---------VADKLSLSSIKLYVVPVIQTQAE 211

  Fly   136 -------RLVSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGE 193
                   |:::       |......::..|  ...::.||......||:|....||.|.|.:|..
Worm   212 PVQRVQRRIIA-------TKIIHKLALFLP--PNEIRKELCPIVTTLCKDANSNVRVAVAQRLFV 267

  Fly   194 FAKVVETEY-LKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDS 257
            .|..::..: :.|.|:|::|.|..|::.:||..|:.:......|..:|..:|.:...:::...::
Worm   268 IANALKNSHDVVSCLLPSYVHLLNDEEMNVREAAMNSLTDAFSLFTRDARKHTLFSVIKKLTEEA 332

  Fly   258 ------------------SWRVRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAV 304
                              ||.:..::.:  :|....:.   |...:|.....|.:..:..:|..:
Worm   333 LEKKNEGLAVISNNFGKWSWELNELLDQ--LDKSWVLN---TYCKMVQISDELCEGPQKNIRNVL 392

  Fly   305 ATKVKDFCANLD-KVNQVQIILSSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLL 368
            .   |..|.|.. .:...:..:..:||::....:|.:..|:.::||   ....:|..:.....|:
Worm   393 K---KTCCFNYPCMLTMFKKHVDRLLPFLEMFCTDHDEEVRVSIAS---SYHEVLTMFPDKPDLI 451

  Fly   369 PLFLIQLKDECPEVRLNIISNLDCVNDVI-----------GIQQLSQSLLPAIVELAEDSKWRVR 422
            |.|:..|.....:|...|..||..:..::           .:||:.:.||.....|...|.||..
Worm   452 PPFIELLHGGSSDVIAKISHNLSKILPILYENVKENPGRTTVQQVDRLLLGCNQILRTSSSWRSH 516

  Fly   423 LAIIEYMPALAGQLGQE-FFDQKLRGLCMGWLNDHVYAIREAATLNMKKLVEQFGAPWAEQAIIP 486
            .|.::.:..|...:.:| ..|..:..|....||......|.||...:..|::..........|:.
Worm   517 EAFLKSLKTLTNCIDEEVIIDTFVPLLRKEVLNVRAIPCRIAACETLLILLKSISKADTRTEIMQ 581

  Fly   487 MI-LVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVLLLAADPVANVRFNVAKTLQKIS 550
            .. ..:|.:.....|:|.:....::..|....|..:..|...|.|.:|||:|:|....|.|.||.
Worm   582 FFNEELSTHSCCYRRITYIDVAELVLSVFSKRIFIQHFLDDTLRLTSDPVSNIRIRAIKFLPKIK 646

  Fly   551 PFL------------EASVIDAQVKPTLDKLNTDTDVDVKHFAAQ 583
            ..|            |.||.: |:|.|  :||..|...:...|.:
Worm   647 SKLILPEDEEVLLKIENSVKE-QLKST--ELNGPTRALINQAAVE 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	16/104 (15%)
		HEAT repeat	15..39	CDD:293787	5/16 (31%)
		HEAT repeat	53..80	CDD:293787	4/38 (11%)
		HEAT repeat	90..120	CDD:293787	7/29 (24%)
		HEAT repeat	129..154	CDD:293787	6/35 (17%)
		HEAT repeat	165..194	CDD:293787	10/28 (36%)
		HEAT_2	175..267	CDD:290374	23/110 (21%)
		HEAT_EZ	181..230	CDD:290247	15/49 (31%)
		HEAT repeat	206..232	CDD:293787	8/25 (32%)
		HEAT repeat	247..271	CDD:293787	2/41 (5%)
		HEAT repeat	285..313	CDD:293787	4/27 (15%)
		HEAT repeat	327..357	CDD:293787	6/29 (21%)
		HEAT repeat	366..392	CDD:293787	8/25 (32%)
		HEAT repeat	403..432	CDD:293787	7/28 (25%)
		HEAT repeat	444..470	CDD:293787	6/25 (24%)
		HEAT repeat	481..510	CDD:293787	4/29 (14%)
		HEAT repeat	520..546	CDD:293787	9/25 (36%)
F46C5.6	NP_495884.3	HEAT repeat	202..231	CDD:293787	6/35 (17%)
		CSE1	233..>478	CDD:227944	49/257 (19%)
		HEAT repeat	241..271	CDD:293787	11/29 (38%)
		HEAT repeat	280..311	CDD:293787	9/30 (30%)
		HEAT repeat	375..400	CDD:293787	4/27 (15%)
		HEAT repeat	411..436	CDD:293787	6/27 (22%)
		HEAT repeat	449..479	CDD:293787	8/29 (28%)
		HEAT repeat	495..525	CDD:293787	8/29 (28%)
		HEAT repeat	536..563	CDD:293787	7/26 (27%)
		DUF4655	<761..839	CDD:292185
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810