DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp2A-29B and Ppp2r1a

DIOPT Version :9

Sequence 1:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	NP_476481.1	Gene:	Ppp2r1a / 117281	RGDID:	620907	Length:	589	Species:	Rattus norvegicus

Alignment Length:	585	Identity:	438/585 - (74%)
Similarity:	499/585 - (85%)	Gaps:	2/585 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAASDKSVDDSLYPIAVLIDELKNEDVQLRLNSIKKLSTIALALGEERTRSELIPFLTETIYDED 65
            |||:|.  ||||||||||||||:||||||||||||||||||||||.|||||||:||||:||||||
  Rat     1 MAAADG--DDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDED 63

  Fly    66 EVLLALADQLGNFTSLVGGPEFAMYLIPPLESLATVEETVVRDKAVESLRTVAAEHSAQDLEIHV 130
            |||||||:|||.||:||||||:...|:|||||||||||||||||||||||.::.|||..|||.|.
  Rat    64 EVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHF 128

  Fly   131 VPTLQRLVSGDWFTSRTSACGLFSVCYPRVTQPVKAELRANFRKLCQDETPMVRRAAANKLGEFA 195
            ||.::||..|||||||||||||||||||||:..||||||..||.||.|:|||||||||:||||||
  Rat   129 VPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFA 193

  Fly   196 KVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHLVLPTLRQCASDSSWR 260
            ||:|.:.:||::||.|..||.|:|||||||||||||:|||||||:|:|.||:|||||.|.|.|||
  Rat   194 KVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWR 258

  Fly   261 VRYMVAEKFVDLQKAVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKDFCANLDKVNQVQIIL 325
            ||||||:||.:||||||||||:.|||||||.|:||.|||||||.:.|||:||.||....:..:|:
  Rat   259 VRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIM 323

  Fly   326 SSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGAYQTVEQLLPLFLIQLKDECPEVRLNIISNL 390
            :.|||.:::||||.|.|||||||||||||||:||...|:|.||||||.|||||||||||||||||
  Rat   324 TQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNL 388

  Fly   391 DCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAIIEYMPALAGQLGQEFFDQKLRGLCMGWLND 455
            ||||:||||:||||||||||||||||:|||||||||||||.||||||.||||:||..|||.||.|
  Rat   389 DCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVD 453

  Fly   456 HVYAIREAATLNMKKLVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITT 520
            ||||||||||.|:|||||:||..||...|||.:|.||.:.|||||||.|||:|||:||||.||||
  Rat   454 HVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITT 518

  Fly   521 KLLLPTVLLLAADPVANVRFNVAKTLQKISPFLEASVIDAQVKPTLDKLNTDTDVDVKHFAAQAI 585
            |.:|||||.:|.||||||||||||:||||.|.|:.|.:.::|||.|:||..|.|||||:||.:|:
  Rat   519 KHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEAL 583

Fly 586 585
Rat 584 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	87/99 (88%)
		HEAT repeat	15..39	CDD:293787	22/23 (96%)
		HEAT repeat	53..80	CDD:293787	22/26 (85%)
		HEAT repeat	90..120	CDD:293787	24/29 (83%)
		HEAT repeat	129..154	CDD:293787	18/24 (75%)
		HEAT repeat	165..194	CDD:293787	22/28 (79%)
		HEAT_2	175..267	CDD:290374	68/91 (75%)
		HEAT_EZ	181..230	CDD:290247	35/48 (73%)
		HEAT repeat	206..232	CDD:293787	18/25 (72%)
		HEAT repeat	247..271	CDD:293787	18/23 (78%)
		HEAT repeat	285..313	CDD:293787	20/27 (74%)
		HEAT repeat	327..357	CDD:293787	22/29 (76%)
		HEAT repeat	366..392	CDD:293787	23/25 (92%)
		HEAT repeat	403..432	CDD:293787	27/28 (96%)
		HEAT repeat	444..470	CDD:293787	19/25 (76%)
		HEAT repeat	481..510	CDD:293787	17/28 (61%)
		HEAT repeat	520..546	CDD:293787	20/25 (80%)
Ppp2r1a	NP_476481.1	HEAT repeat	13..37	CDD:293787	22/23 (96%)
		HEAT repeat	51..78	CDD:293787	22/26 (85%)
		HEAT repeat	88..118	CDD:293787	24/29 (83%)
		HEAT repeat	127..152	CDD:293787	18/24 (75%)
		HEAT repeat	163..192	CDD:293787	22/28 (79%)
		HEAT	166..196	CDD:397231	23/29 (79%)
		HEAT	187..>462	CDD:224331	206/274 (75%)
		HEAT repeat	204..234	CDD:293787	21/29 (72%)
		HEAT repeat	245..269	CDD:293787	18/23 (78%)
		HEAT repeat	283..311	CDD:293787	20/27 (74%)
		HEAT repeat	325..355	CDD:293787	22/29 (76%)
		HEAT repeat	364..390	CDD:293787	23/25 (92%)
		HEAT repeat	401..430	CDD:293787	27/28 (96%)
		HEAT repeat	442..468	CDD:293787	19/25 (76%)
		HEAT repeat	479..508	CDD:293787	17/28 (61%)
		HEAT repeat	518..544	CDD:293787	20/25 (80%)
		HEAT repeat	557..586	CDD:293787	15/27 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1760
eggNOG	1	0.900	-	-		E1_KOG0211
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68559
Inparanoid	1	1.050	863	1.000	Inparanoid score	I405
OMA	1	1.010	-	-		QHG54034
OrthoDB	1	1.010	-	-		D171719at33208
OrthoFinder	1	1.000	-	-		FOG0001701
OrthoInspector	1	1.000	-	-		otm46148
orthoMCL	1	0.900	-	-		OOG6_101100
Panther	1	1.100	-	-	O	PTHR10648
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1096
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840