DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp2A-29B and ppp4r4

DIOPT Version :9

Sequence 1:	NP_001245944.1	Gene:	Pp2A-29B / 2768940	FlyBaseID:	FBgn0260439	Length:	650	Species:	Drosophila melanogaster
Sequence 2:	XP_002933259.3	Gene:	ppp4r4 / 100487144	XenbaseID:	XB-GENE-1011051	Length:	874	Species:	Xenopus tropicalis

Alignment Length:	721	Identity:	144/721 - (19%)
Similarity:	245/721 - (33%)	Gaps:	235/721 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DELKNEDVQLRLNSIKKLSTIALALGEERTRSELI---PFL-----TETIYDEDEVLLALADQLG 76
            :|::...|...||.|:: :...|:.|::...:.::   |.|     |:|:   ..|:..:.:.|.
Frog    52 EEIERLTVDEELNDIER-AVFLLSSGQDIQGTSVVANLPILIRQSPTDTL---RRVVPKVREVLH 112

  Fly    77 NFTSLVGGPEFAMYLIPPLESLATVEETVV-------------------RDKAVES--LRTVAA- 119
                 |.|.|  |.|......||.::|..|                   ||..|.:  |.|:.|
Frog   113 -----VAGVE--MQLTAAYSFLAILQEESVSIHSYCHSFLQIILQNLEHRDTGVSNAWLDTLLAV 170

  Fly   120 -EHSAQDLEIHVV--PTLQRLVSGDWFTSRTSACGLFSVCYPRV-TQPVKAELRANFRKLCQDET 180
             |.|.::...|.:  |.:.:........||.::|.:......:. ...:|.|:....:.||||..
Frog   171 IEVSPKETIRHEILNPLVSKAQLSQTLQSRLASCKILGKLASKFEVHVIKREILPLVKSLCQDVE 235

  Fly   181 PMVRRAAANKLGEFAKVVETEYLKSDLIPNFVQLAQDDQDSVRLLAVEACVSIAQLLPQDDVEHL 245
            ..||.....:|...|:.:..|..|:.::|..|:||:|:..||||.|.|..|::..:...:|...:
Frog   236 YEVRSCMCRQLEFIAQGIGAELTKTMVLPELVELARDEGSSVRLAAFETMVNLLPIFDHEDRSQI 300

  Fly   246 VLPTLRQ-C----ASDSS--------------------------WRVRYM--------------- 264
            |||.::. |    .:|.|                          |.:.:.
Frog   301 VLPLVKSFCEKSFKADESVLASLSLQLGKLCHGLQGIFTQEQHIWFLEFYKKLCRLGLHQENGHS 365

  Fly   265 --------VAEKFVDLQK-----------AVGPEITRVDLVPAFQYLLKDAEAEVRAAVATKVKD 310
                    :.:|::.::|           .||.:...:||...|
Frog   366 DNQIQSLELEKKYLTVRKNCAYNFPAMAIFVGSKNFHIDLYATF--------------------- 409

  Fly   311 FCANLDKVNQVQIILSSILPYVRDLVSDPNPHVKSALASVIMGLSPMLGA--YQTVEQLLPL--- 370
            ||                      |..||:..|:..:|.....:|.:||:  |...::|:.|
Frog   410 FC----------------------LCHDPDVPVRYTMAVGFYEVSKLLGSSVYIIHKELVALLQD 452

  Fly   371 ----FLIQLKDECPEVRLNIIS----NLDCVNDVIGIQQLSQSLLPAIVELAEDSKWRVRLAIIE 427
                .|..|.|..||. |.:::    |....|.::.:..|..:|..|...:|...|||....:::
Frog   453 DSLEILDALLDHIPET-LELMTSSGENSALENKLMVVPDLIPALTSAEQRVANSLKWRSHEKLLQ 516

  Fly   428 YMPAL-----AGQLGQEFFDQKLRGLCMGWLNDHVYAIREAATLNM-----------------KK 470
            ....|     :.|:...|..:....:    |.::|..:::||...:                 :|
Frog   517 KYSCLPHIISSDQIYYRFLHRMFTII----LTNNVLPVQKAAARTLCIFLRYNRKQEQRHEIIQK 577

  Fly   471 LVEQFGAPWAEQAIIPMILVMSRNKNYLHRMTCLFCLNVLAEVCGTDITTKLLLPTVLLLAADPV 535
            |:||.|                :.|:|.:|...|.....:.|........|.....||.|..|||
Frog   578 LIEQLG----------------QGKSYWNRQRFLDTCEYIMEFFSKSFFCKYFFLAVLELTNDPV 626

  Fly   536 ANVRFNVAKTLQKISPF------------LEASV-----------IDAQVKPT---LDKLNTDTD 574
            ||:|..|...|.|:...            ||..|           :.|.||.|   ||::....|
Frog   627 ANIRMKVCYMLPKLKSTLKLPGDKHLLQQLEMCVRKLLCQEKDKDVLAVVKKTVLELDRMELSMD 691

  Fly   575 VDVKHF 580
            ...|.|
Frog   692 AFQKRF 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp2A-29B	NP_001245944.1	HEAT_2	15..115	CDD:290374	25/123 (20%)
		HEAT repeat	15..39	CDD:293787	5/18 (28%)
		HEAT repeat	53..80	CDD:293787	6/34 (18%)
		HEAT repeat	90..120	CDD:293787	11/52 (21%)
		HEAT repeat	129..154	CDD:293787	5/26 (19%)
		HEAT repeat	165..194	CDD:293787	9/28 (32%)
		HEAT_2	175..267	CDD:290374	30/145 (21%)
		HEAT_EZ	181..230	CDD:290247	17/48 (35%)
		HEAT repeat	206..232	CDD:293787	11/25 (44%)
		HEAT repeat	247..271	CDD:293787	7/77 (9%)
		HEAT repeat	285..313	CDD:293787	3/27 (11%)
		HEAT repeat	327..357	CDD:293787	6/29 (21%)
		HEAT repeat	366..392	CDD:293787	9/36 (25%)
		HEAT repeat	403..432	CDD:293787	6/28 (21%)
		HEAT repeat	444..470	CDD:293787	4/42 (10%)
		HEAT repeat	481..510	CDD:293787	4/28 (14%)
		HEAT repeat	520..546	CDD:293787	11/25 (44%)
ppp4r4	XP_002933259.3	HEAT repeat	144..172	CDD:293787	6/27 (22%)
		HEAT repeat	182..213	CDD:293787	4/30 (13%)
		HEAT repeat	222..248	CDD:293787	8/25 (32%)
		HEAT repeat	259..288	CDD:293787	13/28 (46%)
		HEAT repeat	300..324	CDD:293787	6/23 (26%)
		HEAT repeat	342..395	CDD:293787	3/52 (6%)
		HEAT repeat	404..430	CDD:293787	10/68 (15%)
		HEAT repeat	441..467	CDD:293787	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D447572at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920