DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33282 and SLC2A6

DIOPT Version :9

Sequence 1:	NP_001097067.1	Gene:	CG33282 / 2768939	FlyBaseID:	FBgn0053282	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_060055.2	Gene:	SLC2A6 / 11182	HGNCID:	11011	Length:	507	Species:	Homo sapiens

Alignment Length:	477	Identity:	109/477 - (22%)
Similarity:	211/477 - (44%)	Gaps:	47/477 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LQQKTRYQLLATVIVNIITFGHGVGVGWLSPTLTKIQTADSPLDFEVNLAQISWLGSMLGLDSLC 74
            ||.|..:  |||....:..|..|..:.:.||.:..::.:..| |..:..:|.||.||:..|.:..
Human    33 LQNKRVF--LATFAAVLGNFSFGYALVYTSPVIPALERSLDP-DLHLTKSQASWFGSVFTLGAAA 94

  Fly    75 GNLTIAMLIERAGRKFCLYLMAGPYACIWILIYCASNVYYLYAARFLCGFTGGAGYLVVPIFISE 139
            |.|:..:|.:..|||..:...|.|.|..:.|:..|..::.|...|.|.||.||.....:|:::||
Human    95 GGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSE 159

  Fly   140 VADSNIRGALTSMVMLSVDLGILAGYILSTYLAYH------VVPFLAIILPVAYFIANIMLPETA 198
            :|...:||||.:...|....|.|:.|.|...|.:.      ..|.|.:||.:::      :|.:.
Human   160 IAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSF------MPNSP 218

  Fly   199 PYLLKKSQLAAAENSFRYYRNQRSAICEQTSKVNFEELRTAVLSQQTRNATPLSYKDLTTKPALK 263
            .:||.:.:...|..:..:.|.     .:......||:::..|..|.:|    :|:.:.......:
Human   219 RFLLSRGRDEEALRALAWLRG-----TDVDVHWEFEQIQDNVRRQSSR----VSWAEARAPHVCR 274

  Fly   264 GFAASIVLSLGYQFSGVFSFINYMSDIFKASGSVVDVNTATIIIGLVQIVGVYTSTILVDIVGRR 328
            ....::::.|..|.:|:...:.|:..||.::..::.......|:|.|:::.|..:.:.:|:.||:
Human   275 PITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRK 339

  Fly   329 VLMLISTMGVGIGCIAFGCFTYLA-------KIYDLSDFNW----------------LPLVLMII 370
            ||:.:|...:....:..|.:.:..       ....|...:|                :||:..::
Human   340 VLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATML 404

  Fly   371 ICYVANIGLIGIFFLVLVELFPVKIRSLATSLSVIFLSLLVFGTLKLFPLMLHYWGISFTMWFSA 435
            ......:|...|.:|::.|:.|::.|.:|:.|.|:...|..|...|.|..::..:|:....:|.|
Human   405 FIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFA 469

  Fly   436 ASALLTFFYFWLFLQETKGKSM 457
            |..|::..:....:.||||:|:
Human   470 AICLVSLVFTGCCVPETKGRSL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33282	NP_001097067.1	MFS	21..448	CDD:119392	99/455 (22%)
CG33282	NP_001097067.1	MFS_1	53..409	CDD:284993	84/384 (22%)
SLC2A6	NP_060055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		Dileucine internalization motif. /evidence=ECO:0000255	5..6
		MFS_GLUT6_Class3	39..493	CDD:340992	106/471 (23%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	286..292		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53651
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950