DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33281 and VBA5

DIOPT Version :9

Sequence 1:	NP_995620.1	Gene:	CG33281 / 2768938	FlyBaseID:	FBgn0053281	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_013031.3	Gene:	VBA5 / 853980	SGDID:	S000001813	Length:	582	Species:	Saccharomyces cerevisiae

Alignment Length:	543	Identity:	98/543 - (18%)
Similarity:	168/543 - (30%)	Gaps:	213/543 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GWVASNICLGGLVGTFLFTWLADRIGRKLCLMWMALPNLLGWVIIPFARTPMHLIIARFIGGAAG 120
            ||:.:...|...:.:.::...|..||.:..|:...|....|.:|...|.:...||..|.:.|..|
Yeast    75 GWLVTGYSLPNAILSLIWGRFASIIGFQHSLILAILIFEAGSLIAALASSMNMLIFGRVVAGVGG 139

  Fly   121 GG----CFTV------------------------------------------------IPI---- 129
            .|    ||.:                                                :||
Yeast   140 SGLQTLCFVIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLA 204

  Fly   130 ---YIAELASDNIRGIL-----------------------------GV------FLVLTCNFGLV 156
               ::....::| :|||                             |:      |....|:.|||
Yeast   205 IIMFLLTYKAEN-KGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGFALCSAGLV 268

  Fly   157 LAFVLGYYFNYAQVSWIVSS-LSFVFVGCFWFMPETPQHLAKINKIEEAEHSLRY--YRNIKSNP 218
            | |:||..|...:.||.... ::::.:|...|:                 .||.|  :...|.||
Yeast   269 L-FLLGLTFGGNKYSWNSGQVITYLVLGVLLFI-----------------FSLVYDFFLFDKFNP 315

  Fly   219 AKELSEELQLELQKLKTTEKTTADGVDDDDAATGVTWSDFAEGKTRKAFLIGLGLISFNQLCGCF 283
            ..:......|.|::|                             ..|..:|.:.:::|....|..
Yeast   316 EPDNISYRPLLLRRL-----------------------------VAKPAIIIVNMVTFLLCTGYN 351

  Fly   284 AMLNYTAVIFE--------QAGSSLPPTVAAIIVGVIQLMGTYASTVLVERLG--RKILL---LV 335
            ..:.|:...|:        :||..|.|.|...::..|      ||.|:.::||  :.:|:   ::
Yeast   352 GQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAI------ASGVITKKLGLVKPLLIFGGVL 410

  Fly   336 SAVGIGLGQSAMGTYSYFQMLGC---------------------------PVASFSWVPIAGF-S 372
            ..:|.||......|.:....:|.                           |.|:..::.:..| :
Yeast   411 GVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMSAQLQITKDRPEAAMDFIEVTAFNT 475

  Fly   373 FMLFLAAV--GLLSLPFLVVS--------EIMPQKIRSTAIMILM---------STLWLISTCAV 418
            ||..|...  |:||......|        .:.|.:.::...|||.         ||:..|.:.::
Yeast   476 FMKSLGTTLGGVLSTTVFSASFHNKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSI 540

  Fly   419 KLMPVFTESLGMHGTVFMFASLS 441
            |  .||...||.:...|:|.|.|
Yeast   541 K--NVFWMDLGFYALGFLFCSFS 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33281	NP_995620.1	MFS	50..452	CDD:119392	98/543 (18%)
VBA5	NP_013031.3	MFS_Azr1_MDR_like	43..493	CDD:341045	81/471 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900