DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33281 and MPH3

DIOPT Version :9

Sequence 1:	NP_995620.1	Gene:	CG33281 / 2768938	FlyBaseID:	FBgn0053281	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_012694.1	Gene:	MPH3 / 853625	SGDID:	S000003921	Length:	602	Species:	Saccharomyces cerevisiae

Alignment Length:	511	Identity:	130/511 - (25%)
Similarity:	210/511 - (41%)	Gaps:	100/511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 STGGDKYQYLAA----ISVNIISISY-----GAFCGWPSSSFLELSSENSPLDTGPLTPTDQGWV 58
            :|..:.|...||    :|..:|...|     |||...|... .:..|:|.  .||....:....:
Yeast    88 ATALNTYPKAAAWSLLVSTTLIMEGYDTAILGAFYALPIFQ-RKFGSQND--KTGEWEISASWQI 149

  Fly    59 ASNIC--LGGLVGTFLFTWLADRIGRKLCLMWMALPNLLGWVIIPFARTPMHLIIARFIGGAAGG 121
            ...:|  .|.:||..|.....|.:|.:..|: :||..|..:..|.:....:.:|.   :|.|..|
Yeast   150 GLTLCYMAGEIVGLQLTGPSVDLVGNRYTLI-IALFFLAAFTFILYFCNSLGMIA---VGQALCG 210

  Fly   122 ---GCFTVIPI-YIAELASDNIRGILGVFLVLTCNFGLVLA-------------FVLGYYFNYAQ 169
               |||..:.: |.:|:....:|..|..:..|...||.:.|             ..|||...:|
Yeast   211 MPWGCFQCLTVSYASEICPLALRYYLTTYSNLCWLFGQLFAAGIMKNSQKKYADSELGYKLPFA- 274

  Fly   170 VSWIVSSLSFVFVGCFWFMPETPQHLAKINKIEEAEHSLRYYRNIK-SNPAKELSEELQLELQKL 233
            :.||:...  :.:|.| |.||:|..|.|..:.:||..|||  |.:. ..|.||:.  :.||:.|:
Yeast   275 LQWILPVP--LALGIF-FAPESPWWLVKKGRFDEARRSLR--RTLSGKGPEKEIL--VTLEVDKI 332

  Fly   234 KTT---EK--TTADGVDDDDAATGVTWSDFAEGK-----TRKAFLIGLGLISFNQLCGCFAMLNY 288
            |.|   ||  |:.:|          ::||..|.|     ||...|...|    ...||.. ::.|
Yeast   333 KVTIDKEKRLTSKEG----------SYSDCFEDKINRRRTRITCLCWAG----QATCGSI-LIGY 382

  Fly   289 TAVIFEQAGSSLPPTVAAIIVGVIQ----LMGTYASTVLVERLGRKILLLVSAVGIGLGQSAMGT 349
            :...:|:||.|   |..:....:||    :..|:.|....:..||..|.   |.|:     |..|
Yeast   383 STYFYEKAGVS---TEMSFTFSIIQYCLGICATFLSWWASKYFGRYDLY---AFGL-----AFQT 436

  Fly   350 YSYFQM--LGC------PVASFSWVPIAGFSFMLFLAAVGLLSLPFLVVSEIMPQKIRSTAIMIL 406
            ..:|.:  |||      .:.|.|.:....|.:.|     |:..:.|.:|||:...::|:..|::.
Yeast   437 IVFFIIGGLGCSSTHGSKMGSGSLLMAVAFFYNL-----GIAPVVFCLVSEMPSSRLRTKTIILA 496

  Fly   407 MSTLWLIS-TCAVKLMPVFTESLGMHG--TVFMFASLSFLAAIFIAIFVPETKGKS 459
            .:|..::| .|:|.::..........|  :.|.:..|.|...|:..:.:|||.||:
Yeast   497 RNTYNVVSIICSVLILYQLNSKKWNWGAKSGFFWGVLCFCTLIWAVVDLPETAGKT 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33281	NP_995620.1	MFS	50..452	CDD:119392	110/446 (25%)
MPH3	NP_012694.1	SP	72..556	CDD:273317	130/511 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830