DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33281 and SLC2A4

DIOPT Version :9

Sequence 1:	NP_995620.1	Gene:	CG33281 / 2768938	FlyBaseID:	FBgn0053281	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001033.1	Gene:	SLC2A4 / 6517	HGNCID:	11009	Length:	509	Species:	Homo sapiens

Alignment Length:	450	Identity:	120/450 - (26%)
Similarity:	194/450 - (43%)	Gaps:	63/450 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SPLDTGPLTPTDQGWVAS--NICLGGLVGTFLFTWLADRIGRKLCLMWMALPNLLGWVIIPFART 105
            |.:..|.||..   |..|  ...:||::.:||...::..:|||..::...:..:||..::..|..
Human    70 SSIPPGTLTTL---WALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANA 131

  Fly   106 PMH---LIIARFIGGAAGGGCFTVIPIYIAELASDNIRGILGVFLVLTCNFGLVLAFVLGYYFNY 167
            ...   ||:.||:.||..|....::|:|:.|:|..::||.||....|....|:::|.|||.....
Human   132 AASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLL 196

  Fly   168 AQVS-W--------IVSSLSFVFVGCFWFMPETPQHLAKINKIE-EAEHSLR----------YYR 212
            ...| |        :.:.|..|.:.   |.||:|::|..|..:| .|..||:          ...
Human   197 GTASLWPLLLGLTVLPALLQLVLLP---FCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLA 258

  Fly   213 NIKSNPAKELSEELQLELQKLKTTEKTTADGVDDDDAATGVTWSDFAEGKTRKAFLIGLGLISFN 277
            .:|....| |..|..|.|.:|                        ......|:..:|.:.|....
Human   259 ELKDEKRK-LERERPLSLLQL------------------------LGSRTHRQPLIIAVVLQLSQ 298

  Fly   278 QLCGCFAMLNYTAVIFEQAGSSLPPTVAAIIVGVIQLMGTYASTVLVERLGRKILLLVSAVGIGL 342
            ||.|..|:..|:..|||.||.. .|..|.|..||:..:.|..|.:||||.||:.|.|:...|: .
Human   299 QLSGINAVFYYSTSIFETAGVG-QPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGM-C 361

  Fly   343 GQSAMGTYSYFQMLGCPVASFSWVPIAGFSFMLFLAAVGLLSLPFLVVSEIMPQKIRSTAIMILM 407
            |.:.:.|.:...:...|..|:..: :|.|.|:.|. .:|...:|:.:|:|:..|..|..|:.:..
Human   362 GCAILMTVALLLLERVPAMSYVSI-VAIFGFVAFF-EIGPGPIPWFIVAELFSQGPRPAAMAVAG 424

  Fly   408 STLWLISTCAVKLMPVFTESLGMHGTVF-MFASLSFLAAIFIAIFVPETKGKSVDAILAS 466
            .:.|..:...........|::|.:  || :||.|.....||..:.||||:|::.|.|.|:
Human   425 FSNWTSNFIIGMGFQYVAEAMGPY--VFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAA 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33281	NP_995620.1	MFS	50..452	CDD:119392	110/427 (26%)
SLC2A4	NP_001033.1	Interaction with SRFBP1. /evidence=ECO:0000269\|PubMed:16647043	7..13
		Sugar_tr	27..483	CDD:306568	120/449 (27%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	298..304		3/5 (60%)
		Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:8300557	489..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840