DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33281 and Slc2a8

DIOPT Version :9

Sequence 1:	NP_995620.1	Gene:	CG33281 / 2768938	FlyBaseID:	FBgn0053281	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_062361.1	Gene:	Slc2a8 / 56017	MGIID:	1860103	Length:	477	Species:	Mus musculus

Alignment Length:	494	Identity:	139/494 - (28%)
Similarity:	226/494 - (45%)	Gaps:	87/494 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YLAAISVNIISISYGAFCGWPSSSFLELSSENSPLDTGP----LTPTDQGWVASNICLGGLVGTF 71
            :||:.:..:..:|:|...|:.|.:...|..      |.|    |......|..:.:.||...|..
Mouse    27 FLASFAAALGPLSFGFALGYSSPAIPSLRR------TAPPALRLGDNAASWFGAVVTLGAAAGGI 85

  Fly    72 LFTWLADRIGRKLCLMWMALPNLLGWVIIPFARTPMHLIIARFIGGAAGGGCFTVIPIYIAELAS 136
            |..||.||.||||.|:...:|.:.|:.:|..||....|:..|.:.|.|.|....|.|:||:|:|.
Mouse    86 LGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAY 150

  Fly   137 DNIRGILGVFLVLTCNFGLVLAFVLGYYFNYAQVSWIVSSLSFVFVGC---------FWFMPETP 192
            ..:||:||..:.|....|::||:|.|         |::.......:||         ..:|||||
Mouse   151 PAVRGLLGSCVQLMVVTGILLAYVAG---------WVLEWRWLAVLGCVPPTLMLLLMCYMPETP 206

  Fly   193 QHLAKINKIEEAEHSLRYY----RNIKSNPAKELSEELQLELQKLKTTEKTTADGVDDDDAATGV 253
            :.|...::.:||..:||:.    ...:..|.....:..||.|.:                 ..|:
Mouse   207 RFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLALLR-----------------RPGI 254

  Fly   254 TWSDFAEGKTRKAFLIGLGLISFNQLCGCFAMLNYTAVIFEQA---GSSLPPTVAAIIVGVIQLM 315
                      .|..:||:.|:.|.||.|..|::.|...|||:|   .|||    |::.||:||::
Mouse   255 ----------YKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKDSSL----ASVTVGIIQVL 305

  Fly   316 GTYASTVLVERLGRKILLLVSAVGIGLGQSAMGTY--------SYFQMLG-CPVAS--------F 363
            .|..:.::::|.||::||.:|.|.:....||.|||        |....:| .|:|:        .
Mouse   306 FTAVAALIMDRAGRRLLLALSGVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGL 370

  Fly   364 SWVPIAGFSFMLFLA--AVGLLSLPFLVVSEIMPQKIRSTAIMILMSTLWLISTCAVKLMPVFTE 426
            :|:.:.  |..||:|  |||...:|:|::|||.|..::..|..|.:.|.|.::....|......|
Mouse   371 AWLAVG--SMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVME 433

  Fly   427 SLGMHGTVFMFASLSFLAAIFIAIFVPETKGKSVDAILA 465
            .|..:|..::.|:...|:.:|....||||||::::.:.|
Mouse   434 MLRPYGAFWLTAAFCALSVLFTLTVVPETKGRTLEQVTA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33281	NP_995620.1	MFS	50..452	CDD:119392	123/436 (28%)
Slc2a8	NP_062361.1	Dileucine internalization motif. /evidence=ECO:0000269\|PubMed:16723738	12..13
		Sugar_tr	29..474	CDD:278511	138/492 (28%)
		MFS	31..459	CDD:119392	130/475 (27%)
		Monosaccharide binding. /evidence=ECO:0000250\|UniProtKB:P11166	268..274		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48021
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X26
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840