DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33281 and SLC2A12

DIOPT Version :9

Sequence 1:	NP_995620.1	Gene:	CG33281 / 2768938	FlyBaseID:	FBgn0053281	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_660159.1	Gene:	SLC2A12 / 154091	HGNCID:	18067	Length:	617	Species:	Homo sapiens

Alignment Length:	556	Identity:	120/556 - (21%)
Similarity:	227/556 - (40%)	Gaps:	119/556 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GGDKYQYLAAISVNIISISYGAFCGWPSSSFLELSSENSPLDTGPLTPTDQGWVASNICLGGLVG 69
            |...:.:|::::..:..:..|...|..|.:.|::.:..:      |:..:|..|.|::.:|.|:.
Human    35 GCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLA------LSCHEQEMVVSSLVIGALLA 93

  Fly    70 TFLFTWLADRIGRKLCLMWMALPNLLGWVIIPFARTPMHLIIARFIGGAAGGGCFTVIPIYIAEL 134
            :.....|.||.||:..::..:....||.:::..:.:...||:.|...|.:.........:||||:
Human    94 SLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEI 158

  Fly   135 ASDNIRGILGVFLVLTCNFGLVLAFVLGYYFNYAQVSW-----IVSSLSFVFVGCFWFMPETPQH 194
            |..:.||:|.....|....|::.|::..|.|......|     :|..|..:.....:|:|.:|:.
Human   159 APQHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRF 223

  Fly   195 LAKINKIEEAEHSLRYYRNIKSNPAKELSEELQLELQKLKTTEKTTADGVDDDDAATGVTWSDF- 258
            |....:...|...|...|.:     .:.:|||.:....||             |......|..|
Human   224 LVMKGQEGAASKVLGRLRAL-----SDTTEELTVIKSSLK-------------DEYQYSFWDLFR 270

  Fly   259 AEGKTRKAFLIGLGLISFNQLCGCFAMLNYTAVIFEQAG--SSLPPTVAAIIVGVIQLMGTYAST 321
            ::...|...:|||.|:.|.|:.|...:|.|.:.:.:..|  |:...::|:..|||::::.|..:|
Human   271 SKDNMRTRIMIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPAT 335

  Fly   322 VLVERLGRKILLLV-------SAVGIGL-----------------------------GQSAMGT- 349
            :||:.:|.|..|.:       |.|.:|:                             |...:.|
Human   336 LLVDHVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTN 400

  Fly   350 -------------------------------------------YSYFQMLGCP--VASF-SWVPI 368
                                                       ::.:|::..|  |.:| .|:.:
Human   401 NNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSL 465

  Fly   369 AGFSFMLFLAA--VGLLSLPFLVVSEIMPQKIRSTAIMILMSTLWLISTCAVKLMPVFTESLGMH 431
            |  |.::::||  :||..:|:||:|||.|..||..|:.:..|..|.|:..........|:.:|:.
Human   466 A--SLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLP 528

  Fly   432 GTVFMFASLSFLAAIFIAIFVPETKGKSVDAILASL 467
            ...|::..:|..:.:|:.:|:|||||.|::.|...|
Human   529 WVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMEL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33281	NP_995620.1	MFS	50..452	CDD:119392	105/494 (21%)
SLC2A12	NP_660159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
SLC2A12	NP_660159.1	Sugar_tr	44..561	CDD:306568	116/542 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0254
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3740
OMA	1	1.010	-	-		QHG53651
OrthoDB	1	1.010	-	-		D430696at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.710