DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and DNF1

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_011093.3	Gene:	DNF1 / 856913	SGDID:	S000000968	Length:	1571	Species:	Saccharomyces cerevisiae

Alignment Length:	1448	Identity:	426/1448 - (29%)
Similarity:	650/1448 - (44%)	Gaps:	343/1448 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 RSESIYTLRRTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVP-PKTPKRDHPNGQFVGNKI 255
            ||:::...|:....| ::..|..:.:.|.....:..|||..|..:| ....:..:|..|:..|||
Yeast   133 RSKTLKWARKNIPNP-FEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKI 196

  Fly   256 RTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFE 320
            ||||||.|:|:|||:|.|||..||:||:.:::|............::.:|::.::.:||:||..|
Yeast   197 RTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIE 261

  Fly   321 DRRRRASDKRINNTTCRVYDG-ETE-----------RYKKVK----------------------- 350
            |.||...|..:|||...:.:| |.|           |:||..
Yeast   262 DSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKR 326

  Fly   351 ----------------------------------------------------------------- 350

Yeast   327 MQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDC 391

  Fly   351 ------WQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEM 409
                  |:.::|||||.:.||:.:||||:||.|||..|.||::|.:||||||||.|:.::....:
Yeast   392 KFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTI 456

  Fly   410 QSIFVPSKFVSR----VEADAPTTKLYRFHGALIH---PTGE--RVPISTECLLLRESRLKNTDY 465
            ::    ||.::|    :|::.|.:.||.:.|.:..   ..||  ..||:...:|||...|:||.:
Yeast   457 RT----SKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKW 517

  Fly   466 IEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWL-----SS 525
            ..|:|::.|.:||.|||:.....|:|::.:::|..|:...::|.|||.|..|...::.     |.
Yeast   518 AMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYDKKGRSR 582

  Fly   526 FTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAET 590
            |: :....:..:..|....|   ||..:::.|.::|:|||:::|:.|..|...|:.:|.|::|:.
Yeast   583 FS-YEFGTIAGSAATNGFVS---FWVAVILYQSLVPISLYISVEIIKTAQAAFIYGDVLLYNAKL 643

  Fly   591 NKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSE-LEKIYSKPG--- 651
            :.....::.||:::|||:::||:|||||||:|.|.|::|.:||..|....:| |..:..:.|
Yeast   644 DYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGIDV 708

  Fly   652 ------APAPPLIPNDNLNSDMAQLTQGTYLTPHAQRI--QEFLVVLAICNTVIVGAAPHRDMMN 708
                  ..|......|.:..::..|:..:...|.....  :||:                ||:..
Yeast   709 ETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFV----------------RDLKG 757

  Fly   709 ASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRS 773
            |||  ||||                                                 |..|
Yeast   758 ASG--EVQQ-------------------------------------------------RCCE--- 768

  Fly   774 VTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINS 838
                   :.:.|| |..|       |...|::|::.
Yeast   769 -------HFMLAL-ALCH-------SVLVEANPDNP----------------------------- 789

  Fly   839 KITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPN 903
                           |::.|                  :|:||||.|||..|.......:.::..
Yeast   790 ---------------KKLDL------------------KAQSPDEAALVATARDVGFSFVGKTKK 821

  Fly   904 QILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIG-----SQEIVLYTKGADSSIMPVLVPC 963
            .:::.  |.|..:|:|||.:|.|:||||.||.:|:..|     ....:|..|||||.|...|...
Yeast   822 GLIIE--MQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQ 884

  Fly   964 SHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSF 1028
            |.::.|.|| |:|...|::||.||||.|.:|:|.|:.::|..|..::.....||.|||..|....
Yeast   885 SGSNSEAIL-EKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVA 948

  Fly  1029 AKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELI 1093
            ..:|..|.|||.|.||||||||||:.|..|..|||.:|||||||.||||||.:|..|...:|||:
Yeast   949 DSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELL 1013

  Fly  1094 RLTARSRDAAE----------TAINFYLTDMEN----DKTTSTLGYGQSLRKKQRALVVDGKTLT 1144
            .:.....|..|          ..::.||.:..|    ::............|...|:|:||..|.
Yeast  1014 VIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALK 1078

  Fly  1145 FIL---DPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQ 1206
            ..|   |.:.|    ||.|.|.|.:|||||.:|.|||.:||:||:.|::.|||||||:|||:|||
Yeast  1079 LALYGEDIRRK----FLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQ 1139

  Fly  1207 MADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFW 1271
            .||||:||:|:||.||||.:|:.:.:||||.||:|.||.|.|.||:.||..|||||..|...:||
Yeast  1140 SADVGIGIAGEEGRQAVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFW 1204

  Fly  1272 YQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHD 1336
            |.:|..|.|..:.:..|:|.|||.|||||.:.:|:.|:.|.:.:.|..|.||:.|.|...:....
Yeast  1205 YGIYNDFDGSYLYEYTYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRK 1269

  Fly  1337 FWLILLDALYQSLVIFFVALCAYAES--------------DVGIWEFGTTITA-SCLFANLVHCA 1386
            |...:||.||||::.||.....|.::              .||:  :.|||.. ||....|:|
Yeast  1270 FLWYMLDGLYQSIICFFFPYLVYHKNMIVTSNGLGLDHRYFVGV--YVTTIAVISCNTYVLLH-- 1330

  Fly  1387 IEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVA 1451
             :.| |.....|.|.||.    |....:..:..:....|..:......:.:...|.|..::.:..
Yeast  1331 -QYR-WDWFSGLFIALSC----LVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFC 1389

  Fly  1452 VLPRLLLTTVRISLCPDD 1469
            :|||....:.:....|.|
Yeast  1390 LLPRFTYDSFQKFFYPTD 1407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	24/49 (49%)
		ATPase-Plipid	250..1473	CDD:273734	413/1389 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	42/197 (21%)
		Cation_ATPase	<880..965	CDD:289987	32/89 (36%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	81/259 (31%)
DNF1	NP_011093.3	ATPase-Plipid	191..1413	CDD:273734	413/1389 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I409
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	653	1.000	Inparanoid score	I106
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.820