Protein Alignment CG33298 and DNF3

DIOPT Version :9

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_013885.1
• Gene: DNF3 / 855197
• SGDID: S000004772
• Length: 1656
• Species: Saccharomyces cerevisiae
• Alignment Length: 1552
• Identity: 410/1552 - (26%)
• Similarity: 649/1552 - (41%)
• Gaps: 431/1552 - (27%)

  Fly   247 NGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLG 311
            |..:..|:|.:::||..||:|:.|..||.::||.||..:.:|..:|..|..|....:||:...:|
Yeast   135 NKPYCDNRITSSRYTFYSFLPRQLYAQFSKLANTYFFIVAVLQMIPGWSTTGTYTTIIPLCVFMG 199

  Fly   312 VTAVKDLFEDRRRRASDKRINNTTCRVY--DGETE------------------------------ 344
            ::..::.::|.||...||..||....|.  ||..:
Yeast   200 ISMTREAWDDFRRHRLDKEENNKPVGVLVKDGNNDAQEVYTLPSSVVSSTAYLTKSAAAENNPPL 264

  Fly   345 ------------------------RYK----KVKWQELRVGDIVHLSNNETVPADILLLRTSDPQ 381
                                    :|.    :.||::|||||.|.|:.::.||||:|||......
Yeast   265 NDDRNSSQGHFLDTHFNNFELLKNKYNVHIHQKKWEKLRVGDFVLLTQDDWVPADLLLLTCDGEN 329

  Fly   382 GVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEA----DAPTTKLYRFHGAL---- 438
            ..|:::|..||||||||.::   ...|:..:...:..::.:.|    :.|...||.|.|.|
Yeast   330 SECFVETMALDGETNLKSKQ---PHPELNKLTKAASGLANINAQVTVEDPNIDLYNFEGNLELKN 391

  Fly   439 -IHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNN-SGPRYKRSQVEQQMNIDV 501
             .:.|..:.|:..:.::.|.|.|:||..:.|:|:::|.|||..:|. ..||.|..::::::|
Yeast   392 HRNDTIMKYPLGPDNVIYRGSILRNTQNVVGMVIFSGEETKIRMNALKNPRTKAPKLQRKIN--- 453

  Fly   502 IWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIF----------WTYIVIL 556
               :||:.::.||..|....:|....| ...|:..||      :.::|          .::|::.
Yeast   454 ---MIIVFMVFVVATISLFSYLGHVLH-KKKYIDQNK------AWYLFQADAGVAPTIMSFIIMY 508

  Fly   557 QVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTE 621
            ..:||||||||:|:.|::|...:..::|::.||||...|.|...|.|||||:.:||:|||||||:
Yeast   509 NTVIPLSLYVTMEIIKVVQSKMMEWDIDMYHAETNTPCESRTATILEELGQVSYIFSDKTGTLTD 573

  Fly   622 NKMIFRRCVVNGSDYNH----PPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQR 682
            ||||||:..:.||.:.|    ..||                  ||. .|....|....|.|.|..
Yeast   574 NKMIFRKFSLCGSSWLHNVDLGNSE------------------DNF-EDNRDNTNSLRLPPKAHN 619

  Fly   683 IQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTI 747
            ....                  |:::......:.::|.|.|.::.|.
Yeast   620 GSSI------------------DVVSIGDQNVLDRLGFSDAPIEKGH------------------ 648

  Fly   748 INGPTTQPQVVSIPADR---YIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSE 809
                  :|.:.:.|..|   ..:...|...|..|....||. ...||        .|.::|..|.
Yeast   649 ------RPSLDNFPKSRNSIEYKGNSSAIYTGRPSMRSLFG-KDNSH--------LSKQASVISP 698

  Fly   810 SESPSPPMKNK-SLSNSIS--PTGRAKAVINSK----ITSIA---TFLNAKTQGKRMKLPSSKTG 864
            ||:.|..:|:. .|...|.  ||    |:.:.|    ..|:|   :.|..||..:.:...|.:
Yeast   699 SETFSENIKSSFDLIQFIQRYPT----ALFSQKAKFFFLSLALCHSCLPKKTHNESIGEDSIE-- 757

  Fly   865 TIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATRE-----YEILKVL 924
                       |::.||||||||.||......:|||:...:.:.....|...|     ||||..:
Yeast   758 -----------YQSSSPDELALVTAARDLGYIVLNRNAQILTIKTFPDGFDGEAKLENYEILNYI 811

  Fly   925 PFDSSRKCMSIVVRQIGS-QEIVLYTKGADSSIMPVL---------------------------- 960
            .|:|.||.||::||.... .:::|..||||:.||..|
Yeast   812 DFNSQRKRMSVLVRMPNQPNQVLLICKGADNVIMERLHDRELAAKKMADICTSTKERKDAEAELV 876

  Fly   961 ---------------------------VP------------------------------------ 962
                                       ||
Yeast   877 LQQRKSLERMVDEEAMARTSLRNSLSSVPRASLSLQAVRKSLSMKNSRTRDPEKQIDSIDQFLET 941

  Fly   963 --------------------------------------CSHNSP-----EGI------------- 971
                                                  .::|.|     ||:
Yeast   942 VKKSDQEIGSVVNKSRKSLHKQQIEKYGPRISIDGTHFPNNNVPIDTRKEGLQHDYDTEILEHIG 1006

  Fly   972 ----------LREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRD 1026
                      :.|:|.|.:|.::.||||.||.|.:.::...|.:|..|:.:.:.||.:|:.::.:
Yeast  1007 SDELILNEEYVIERTLQAIDEFSTEGLRTLVYAYKWIDIGQYENWNKRYHQAKTSLTDRKIKVDE 1071

  Fly  1027 SFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQME 1091
            :.|::|..|.|||.|.|||:|||||.|.|..:..|||.:|:|||||.||||||.||..|......
Yeast  1072 AGAEIEDGLNLLGVTAIEDKLQDGVSEAIEKIRRAGIKMWMLTGDKRETAINIGYSCMLIKDYST 1136

  Fly  1092 LIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILP 1156
            ::.||....:.. :.:|....::::......:            :|:||.|:. :.:.....:..
Yeast  1137 VVILTTTDENII-SKMNAVSQEVDSGNIAHCV------------VVIDGATMA-MFEGNPTYMSV 1187

  Fly  1157 FLRLSKRCASVLCCRSTPLQKAYLVKVVKE-ELNLRTLAIGDGANDVSMIQMADVGVGISGQEGM 1220
            |:.|..:..||:|||::|.|||.:|..::. :.||.||||||||||::|||.||:||||:|:||:
Yeast  1188 FVELCTKTDSVICCRASPSQKALMVSNIRNTDPNLVTLAIGDGANDIAMIQSADIGVGIAGKEGL 1252

  Fly  1221 QAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMD 1285
            ||...:|:::.:||:|.:||..||.:.|.|.|:.:|..|||...|.|....||.|..|||..:.:
Yeast  1253 QASRVSDYSIGQFRFLLKLLFVHGRYNYIRTSKFMLCTFYKEITFYFTQLIYQRYTMFSGSSLYE 1317

  Fly  1286 QMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLD----ALY 1346
            ...|.::|.:|||||.|.||:::|.:....||..|.||..|||...:.    |||.::    |..
Yeast  1318 PWSLSMFNTLFTSLPVLCIGMFEKDLKPMTLLTVPELYSYGRLSQGFN----WLIFMEWVILATT 1378

  Fly  1347 QSLVIFFVALCAY---AESDVGIWEFG-TTITASCLFANLVHCAIEI--RSWTVLHVLSIVLSLG 1405
            .||:|.|:.:..:   :.||..::..| ...||.....|:....:|:  |:|  |...|:|||.|
Yeast  1379 NSLIITFLNVVMWGMSSLSDNTMYPLGLINFTAIVALINVKSQFVEMHNRNW--LAFTSVVLSCG 1441

  Fly  1406 SFYLFAI----------VYDSV--CMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLP---R 1455
            .:.::..          :||..  ..|.||...::|    |           .|.|:|:||   .
Yeast  1442 GWLVWCCALPILNNTDQIYDVAYGFYNHFGKDITFW----C-----------TSLVLALLPITLD 1491

  Fly  1456 LLLTTVRISLCPDDS-------TKVILQSKRERSRGEALLVTWSRSTSASSIYRITD 1505
            ::..|.::.:.|.||       .|..::.|.|......:...|:.....|:..|.||
Yeast  1492 IVYKTFKVMIWPSDSDIFAELEQKSDIRKKLELGAYSEMRQGWTWDKDPSTFTRYTD 1548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	17/49 (35%)
		ATPase-Plipid	250..1473	CDD:273734	401/1515 (26%)
		E1-E2_ATPase	302..>394	CDD:278548	34/151 (23%)
		Cation_ATPase	<880..965	CDD:289987	37/219 (17%)
		HAD_like	<1177..1240	CDD:304363	33/63 (52%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	78/269 (29%)
DNF3	NP_013885.1	P-type_ATPase_APLT_Dnf-like	140..1386	CDD:319770	369/1366 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.670