Protein Alignment CG33298 and DNF2

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_010378.1
• Gene: DNF2 / 851667
• SGDID: S000002500
• Length: 1612
• Species: Saccharomyces cerevisiae
• Alignment Length: 1639
• Identity: 443/1639 - (27%)
• Similarity: 680/1639 - (41%)
• Gaps: 456/1639 - (27%)

  Fly    79 GSAPGGGGQGIP---GVAMAAPSRGHAR-SISHGGGAIVGANGRPIKS---------AMKGHQRA 130
            |||..|.....|   ......||..|.. .::..||:::....:|:|.         ...|....
Yeast    20 GSASNGLSSMSPFDDSFQFEKPSSAHGNIEVAKTGGSVLKRQSKPMKDISTPDLSKVTFDGIDDY 84

  Fly   131 FSQGQITDSPPGSAAPAGRGHSRVGSKTDFILPPGHKEEPARE------PSAPTSATGG------ 183
            .:...|.|....:           |.||:.     |:.|...:      .:.|...|||
Yeast    85 SNDNDINDDDELN-----------GKKTEI-----HEHENEVDDDLHSFQATPMPNTGGFEDVEL 133

  Fly   184 ---RGHSRQASRSESIYTLR--------------RTEAPPWWKRLTLCNY-NTGDKF-------- 222
               .|.:..:.....:..:|              |::...|.|:    |: |..|:|
Yeast   134 DNNEGSNNDSQADHKLKRVRFGTRRNKSGRIDINRSKTLKWAKK----NFHNAIDEFSTKEDSLE 194

  Fly   223 ----EERS--YRTVVPNHTVPPKTPKRDH-PNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANL 280
                :.||  .|||..|..:|......|. |...:..|||||||||.|:|.|||:|.|||..||:
Yeast   195 NSALQNRSDELRTVYYNLPLPEDMLDEDGLPLAVYPRNKIRTTKYTPLTFFPKNILFQFHNFANI 259

  Fly   281 YFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTC--------- 336
            ||:.:::|.............|.:|::.::.:||:||..||.||...|..:|||..
Yeast   260 YFLILLILGAFQIFGVTNPGFASVPLIVIVIITAIKDGIEDSRRTVLDLEVNNTRTHILSGVKNE 324

  Fly   337 ----------------------------------------------------------------- 336
                                                                             
Yeast   325 NVAVDNVSLWRRFKKANTRALIKIFEYFSENLTAAGREKKLQKKREELRRKRNSRSFGPRGSLDS 389

  Fly   337 ----------------------------RVYDGETE-----------RYKKVKWQELRVGDIVHL 362
                                        |..|||..           |:.|..|:.::|||||.:
Yeast   390 IGSYRMSADFGRPSLDYENLNQTMSQANRYNDGENLVDRTLQPNPECRFAKDYWKNVKVGDIVRV 454

  Fly   363 SNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSR----VE 423
            .||:.:|||::||.|||..|.||::|.:||||||||.|:.::    ...|...|:.::|    ||
Yeast   455 HNNDEIPADMILLSTSDVDGACYVETKNLDGETNLKVRQSLK----CSKIIKSSRDITRTKFWVE 515

  Fly   424 ADAPTTKLYRFHGALIHPTGE-----RVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNN 483
            ::.|...||.:.|.......:     ..|::...||||...|:||.:..|:|::.|.:||.|:|.
Yeast   516 SEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINNLLLRGCTLRNTKWAMGMVIFTGDDTKIMINA 580

  Fly   484 SGPRYKRSQVEQQMNIDVIWCVIILLILC----VVGAIGCRMWLSSFTHFPVPYLPPNKLTANME 544
            .....|:|::.:::|..||...::|.|||    :|..:..:....|..:|....:..:..|....
Yeast   581 GVTPTKKSRISRELNFSVILNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFV 645

  Fly   545 SMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQ 609
            |   ||..:::.|.::|:|||:::|:.|..|...|:.:|.|::|:.:.....::.||:::||||:
Yeast   646 S---FWVAVILYQSLVPISLYISVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIE 707

  Fly   610 HIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSE-LEKIYSKPGAPAPP---------LIPNDNLN 664
            :||:|||||||:|.|.|::|.:||..|....:| |..:..:.|.....         ....:.:.
Yeast   708 YIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAGLRKRQGVDVESEGRREKEEIAKDRETMI 772

  Fly   665 SDMAQLTQGTYLTP--------------------HAQR-IQEFLVVLAICNTVIVGAAPHRDMMN 708
            .::..::..|...|                    |.|: .:.||:.||:|::|:|  .|::|
Yeast   773 DELRSMSDNTQFCPEDLTFVSKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLV--EPNKD--- 832

  Fly   709 ASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRS 773
                                                         .|:.:.|
Yeast   833 ---------------------------------------------DPKKLDI------------- 839

  Fly   774 VTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINS 838
                                                                             
Yeast   840 ----------------------------------------------------------------- 839

  Fly   839 KITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPN 903
                                                  :|:||||.|||:.|.......:..|.:
Yeast   840 --------------------------------------KAQSPDESALVSTARQLGYSFVGSSKS 866

  Fly   904 QILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGS-----QEIVLYTKGADSSIMPVLVPC 963
            .::|.  :.|..:|:::|.||.|:||||.||.:::..||     .:.:|..|||||.|...|
Yeast   867 GLIVE--IQGVQKEFQVLNVLEFNSSRKRMSCIIKIPGSTPKDEPKALLICKGADSVIYSRL--- 926

  Fly   964 SHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSF 1028
            .....:..|.|:|...|:.||.||||.|.:|:|.|..::|..|...:.....|:.|||..|....
Yeast   927 DRTQNDATLLEKTALHLEEYATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVT 991

  Fly  1029 AKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELI 1093
            ..:|..|.|||.|.||||||||||::||.|..|||.:|||||||.||||||.:|..:....|||:
Yeast   992 DVIERELILLGGTAIEDRLQDGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELL 1056

  Fly  1094 RLTARSRDAAE------TAINFYLTDMENDKTTSTLGYGQSLRKKQR---------ALVVDGKTL 1143
            .:.|...|..|      ..:|..:|....:|...: |..:.|::.:|         |:::||..|
Yeast  1057 VVKASGEDVEEFGSDPIQVVNNLVTKYLREKFGMS-GSEEELKEAKREHGLPQGNFAVIIDGDAL 1120

  Fly  1144 TFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMA 1208
            ...|:.: ::...||.|.|.|.:|||||.:|.|||.:||:||:.|::.|||||||:|||:|||.|
Yeast  1121 KVALNGE-EMRRKFLLLCKNCKAVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSA 1184

  Fly  1209 DVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQ 1273
            ||||||:|:||.||||.:|:.:.:|||:.||:|.||.|||.||:.||..|||||..|...:|||.
Yeast  1185 DVGVGIAGEEGRQAVMCSDYAIGQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFTLSLFWYG 1249

  Fly  1274 LYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFW 1338
            :|..|.|..:.:..||..|||.|||:|.:.:.|.|:.|::.:.:..|.||:.|.|...:....|.
Yeast  1250 IYNNFDGSYLFEYTYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYRVGILRKEWNQTKFL 1314

  Fly  1339 LILLDALYQSLVIFFVALCAY------AESDVGI---WEFGTTITA----SCLFANLVHCAIEIR 1390
            ..:||.:|||::.||....||      .|:.:|:   :..|..:||    ||.|    :..:|..
Yeast  1315 WYMLDGVYQSVICFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNF----YVFMEQY 1375

  Fly  1391 SWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPR 1455
            .|.....|.|.|||..||.:..::.|...:    ...|......||...:|.|:.:..:..:|||
Yeast  1376 RWDWFCGLFICLSLAVFYGWTGIWTSSSSS----NEFYKGAARVFAQPAYWAVLFVGVLFCLLPR 1436

  Fly  1456 LLLTTVRISLCPDD 1469
            ..:..:|....|.|
Yeast  1437 FTIDCIRKIFYPKD 1450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	370/1279 (29%)
DNF2	NP_010378.1	ATPase-Plipid	229..1456	CDD:273734	401/1410 (28%)