DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP8B4

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_011520348.1	Gene:	ATP8B4 / 79895	HGNCID:	13536	Length:	1257	Species:	Homo sapiens

Alignment Length:	1363	Identity:	409/1363 - (30%)
Similarity:	640/1363 - (46%)	Gaps:	313/1363 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313
            |:..|:|.|:||.:|:|:|.||.|||.||||.||:.:::|..:||||:......::|::.|:.:|
Human    64 QYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIPEISSLTWFTTIVPLVLVITMT 128

  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTS 378
            ||||..:|..|..||.::||....|.  ...:.:..||..::||||:.|.||:.|.||:|||.:|
Human   129 AVKDATDDYFRHKSDNQVNNRQSEVL--INSKLQNEKWMNVKVGDIIKLENNQFVAADLLLLSSS 191

  Fly   379 DPQGVCYIDTCDLDG----------------------------ETNLKRREVVRGFEEM-QSIFV 414
            :|.|:||::|.:|||                            |||||.|..:....|: ..|..
Human   192 EPHGLCYVETAELDGSLCCYKDVPWVECQLFGAQEALPTFLKQETNLKVRHALSVTSELGADISR 256

  Fly   415 PSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKS 479
            .:.|...|..:.|..||.:|.|.|.....:. .::.|.::||...|:||.:..|:|::||.:||.
Human   257 LAGFDGIVVCEVPNNKLDKFMGILSWKDSKH-SLNNEKIILRGCILRNTSWCFGMVIFAGPDTKL 320

  Fly   480 MLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLS----SFTHFPVPYLPPNKLT 540
            |.|:...::||:.:::.||..|:|....|:.|.::.|||..:|.|    .|..|  .:....:.:
Human   321 MQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILAIGNSIWESQTGDQFRTF--LFWNEGEKS 383

  Fly   541 ANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEEL 605
            :.......||:||:||..::|:||||::|:.::...:.|:.:..::.:........|...:.|||
Human   384 SVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMYYSRKAIPAVARTTTLNEEL 448

  Fly   606 GQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQL 670
            |||::||:|||||||:|.|.|:||.:||..|.....:|::         ...|..:....|.:..
Human   449 GQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQ---------KTEITQEKEPVDFSVK 504

  Fly   671 TQG----TYLTPHAQ--------RIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPA 723
            :|.    .:...|..        ::.|||.:||:|:||:
Human   505 SQADREFQFFDHHLMESIKMGDPKVHEFLRLLALCHTVM-------------------------- 543

  Fly   724 NLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPA 788

Human   544 ----------------------------------------------------------------- 543

  Fly   789 QSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQG 853
                               ||..|.
Human   544 -------------------SEENSA---------------------------------------- 549

  Fly   854 KRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREY 918
                              |..:|:.:||||.|||.||.::.....:|:|..|.:.  ..|....|
Human   550 ------------------GELIYQVQSPDEGALVTAARNFGFIFKSRTPETITIE--ELGTLVTY 594

  Fly   919 EILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRY 983
            ::|..|.|:::||.||::||....| |.||:||||:.:...|.|.:.     :|...|...|..:
Human   595 QLLAFLDFNNTRKRMSVIVRNPEGQ-IKLYSKGADTILFEKLHPSNE-----VLLSLTSDHLSEF 653

  Fly   984 AREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQ 1048
            |.||||.|.:|.|.|:...:.:|....::...:.|.|:.|:...:.::|.:|.|||||.:||:||
Human   654 AGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGATAVEDKLQ 718

  Fly  1049 DGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTD 1113
            :||.||:.||..|.|.:|||||||.||||||.|:..:.|..|..:.:.| ..:|.|..
Human   719 EGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIA-GNNAVEVR------- 775

  Fly  1114 MENDKTTSTLGYGQS---------LRKKQR---------------ALVVDGKTLTFIL--DPKSK 1152
            .|..|....| :||:         ..|||:               ||:::|.:|...|  |.|:.
Human   776 EELRKAKQNL-FGQNRNFSNGHVVCEKKQQLELDSIVEETITGDYALIINGHSLAHALESDVKND 839

  Fly  1153 LILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQ 1217
            |    |.|:..|.:|:|||.||||||.:|::||:..|..||||||||||||||:.|.:|||||||
Human   840 L----LELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGANDVSMIKSAHIGVGISGQ 900

  Fly  1218 EGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQV 1282
            ||:|||:|:|::..:||||:||||.||.|.|.|:.:.:.||||||.||..:.||:..:||||.|.
Human   901 EGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQT 965

  Fly  1283 MMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQ 1347
            :.||.::.|:|:::||||.||:|::|:.|::...:..|.|||.|:|.:.:....|::.:|..:|.
Human   966 VYDQWFITLFNIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYT 1030

  Fly  1348 SLVIFFVALCAY---AESD----VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLG 1405
            |||:||:...|:   |..|    .....|..|:..|.:....|..|::...||.::.:.|..|:.
Human  1031 SLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIA 1095

  Fly  1406 SFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH-------WLVIMLSTVVAVLPRLLLTTVRI 1463
            .:  |:|::.......||:..:.   |....:|.|       ||||:|:||.:|:|.:....:::
Human  1096 IY--FSILFTMHSNGIFGIFPNQ---FPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLKV 1155

  Fly  1464 SLCPDDSTKVIL-----------QSKRERSRGEALLVTWSRSTSASSIYRITDYGSKNQIITT 1515
            .|.|..|.::..           .|:|.|:|         ||:|..|.|.........::||:
Human  1156 DLYPTLSDQIRRWQKAQKKARPPSSRRPRTR---------RSSSRRSGYAFAHQEGYGELITS 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	25/49 (51%)
		ATPase-Plipid	250..1473	CDD:273734	397/1307 (30%)
		E1-E2_ATPase	302..>394	CDD:278548	38/119 (32%)
		Cation_ATPase	<880..965	CDD:289987	33/84 (39%)
		HAD_like	<1177..1240	CDD:304363	40/62 (65%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	87/258 (34%)
ATP8B4	XP_011520348.1	PhoLip_ATPase_N	51..116	CDD:292826	25/51 (49%)
		ATPase-Plipid	65..1167	CDD:273734	397/1309 (30%)
		Cation_ATPase	538..634	CDD:289987	39/266 (15%)
		HAD_like	<875..906	CDD:304363	25/30 (83%)
		PhoLip_ATPase_C	906..1160	CDD:292829	87/258 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830