DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp11b

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_083846.2	Gene:	Atp11b / 76295	MGIID:	1923545	Length:	1175	Species:	Mus musculus

Alignment Length:	1307	Identity:	408/1307 - (31%)
Similarity:	607/1307 - (46%)	Gaps:	279/1307 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 RTVVPNHTVPPK---TPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLN 289
            ||:...:..|..   ||::      |:.|:|.::|||:.:|:||||.|||.||||.||:.|.|:.
Mouse    20 RTIYIANRFPQNGLYTPQK------FIDNRIISSKYTIWNFVPKNLFEQFRRVANFYFLIIFLVQ 78

  Fly   290 WV------PEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKK 348
            .:      |..|.       :|:.||:.|||:|..:||..|..||..:|...  ||...:....|
Mouse    79 LMIDTPTSPITSG-------LPLFFVITVTAIKQGYEDWLRHNSDNEVNGAP--VYVVRSGGLVK 134

  Fly   349 VKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIF 413
            .:.:.:||||||.::.:|..|||::||.:....|.|::.|..||||||||....|.....:|::.
Mouse   135 TRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVSVPETAVLQTVA 199

  Fly   414 VPSKFVSRVEADAPTTKLYRFHGALI--HPTGERV-PISTECLLLRESRLKNTDYIEGIVVYAGH 475
            .....::.:|...|...||||.|.:|  ....|.| |:..|.||||.:|||||..|.|:.||.|.
Mouse   200 NLDSLIAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGM 264

  Fly   476 ETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLT 540
            |||..||......|||.||:.||..:|..:|||:...::..|....|.:. ..:..|:.  |:.|
Mouse   265 ETKMALNYKSKSQKRSAVEKSMNTFLIIYLIILISEAIISTILKYTWQAE-EKWDEPWY--NQKT 326

  Fly   541 ANMES-------MWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRA 598
            .:..:       :..|..::|:...:||:|||||:|:.|.|..|.|..::||:..|::::.:...
Mouse   327 EHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNT 391

  Fly   599 MNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSK--PGAPAP------ 655
            .::.|||||::::|||||||||||:|.||.|.:||..|       ::|..|  |..|:|
Mouse   392 SDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGLKY-------QEINGKLVPEGPSPDSTEGE 449

  Fly   656 -PLIPNDNLNSDMAQLTQGTYLT-PHAQR--IQE---FLVVLAICNTVIVGAAPHRDMMNASGII 713
             |.:.:.:..|:.|.||..:..| |.::.  |:|   |...:::|:||
Mouse   450 VPFLGSLSHLSNSAHLTATSLRTSPESETELIKEHDLFFKAVSLCHTV----------------- 497

  Fly   714 EVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSP 778
               ||.|                     ..|..|.:||
Mouse   498 ---QISN---------------------VQTDGIGDGP--------------------------- 511

  Fly   779 PPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSI 843
                        .||.|:|....
Mouse   512 ------------WQPNLAPAQLE------------------------------------------ 522

  Fly   844 ATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVS 908
                                            |.|.||||.|||.||.......:..|...:.|.
Mouse   523 --------------------------------YYASSPDEKALVEAAARAGIIFVGISEETMEVK 555

  Fly   909 MPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILR 973
              :.|....|::|.:|.|||.|:.||::| |..|.|.:|:.|||:|||:|..:        |...
Mouse   556 --VLGRLERYKLLHILEFDSDRRRMSVIV-QAPSGEKLLFAKGAESSILPKCI--------GGEI 609

  Fly   974 EQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLL 1038
            .:|:..:|.:|.:|||.|.:|.|...:.:|.|...|..|...:|::||.:|.|:|..:|.:|.||
Mouse   610 AKTRIHVDEFALKGLRTLCIAYRQFTAKEYEDVDRRLFEARTALQHREEKLADAFQYIEKDLILL 674

  Fly  1039 GATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAA 1103
            |||.:||||||.|.|||.:|..|||.||||||||.|||::::.|...|.:.|.::.|.
Mouse   675 GATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELI------- 732

  Fly  1104 ETAINFYLTDMENDKTTSTLGYGQSLRKK----------QRALVVDGKTLTFILDPKSKLILPFL 1158
                        |.|:.|  |..:.||:.          |..|||||.:|:..|....||   |:
Mouse   733 ------------NQKSDS--GCAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKL---FM 780

  Fly  1159 RLSKRCASVLCCRSTPLQKAYLVKVVK--EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQ 1221
            .:.:.|::|||||..|||||.:::::|  .|..: |||:|||||||||||.|.||:||.|:||.|
Mouse   781 EVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPI-TLAVGDGANDVSMIQEAHVGIGIMGKEGRQ 844

  Fly  1222 AVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQ 1286
            |...:|:.:.||::|.:||..||::.|.|::.::.||||||..|:...|.||.||.||.|.:.|.
Mouse   845 AARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDS 909

  Fly  1287 MYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLY----KNGRLGVAYRPHDFWLILLDALYQ 1347
            :||.|||:.|||||.|...:.::.:...:|...|.||    |||.|.:  :...:|.:|   .:.
Mouse   910 VYLTLYNICFTSLPVLIYSLVEQHIDPHVLQSKPTLYRDISKNGLLSI--KAFLYWTVL---GFS 969

  Fly  1348 SLVIFFVALCAYAESDV---------GIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLS 1403
            ...|||.........|.         |.|.|||.:....:....|..|:|...||.::.|....|
Mouse   970 HAFIFFFGSYFLVGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGS 1034

  Fly  1404 LGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPD 1468
            :..:::|::.|..:.....|.::.|:|.....:|...|..|:|..|..:...::.......|.|.
Mouse  1035 IIFYFIFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAILLMVVTCLFIDVVKKVFDRQLHPT 1099

  Fly  1469 DSTKVIL 1475
            .:.|..|
Mouse  1100 STEKAQL 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	24/55 (44%)
		ATPase-Plipid	250..1473	CDD:273734	401/1278 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	33/91 (36%)
		Cation_ATPase	<880..965	CDD:289987	33/84 (39%)
		HAD_like	<1177..1240	CDD:304363	32/64 (50%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	74/257 (29%)
Atp11b	NP_083846.2	PhoLip_ATPase_N	21..89	CDD:292826	27/73 (37%)
		ATPase-Plipid	39..1105	CDD:273734	402/1279 (31%)
		E1-E2_ATPase	96..>180	CDD:278548	32/85 (38%)
		Cation_ATPase	493..604	CDD:289987	49/267 (18%)
		HAD_like	628..867	CDD:304363	108/263 (41%)
		PhoLip_ATPase_C	846..1099	CDD:292829	74/257 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820