DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP10D

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_065186.3	Gene:	ATP10D / 57205	HGNCID:	13549	Length:	1426	Species:	Homo sapiens

Alignment Length:	1448	Identity:	579/1448 - (39%)
Similarity:	821/1448 - (56%)	Gaps:	248/1448 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 TEAPPW----WKRLTL----------CNYNT----GDKFEER-----SYRTVVPNHTVPPKTPKR 243
            |||..|    |:||..          .||::    |.|..:.     .:|.|||:  :.|...:.
Human     2 TEALQWARYHWRRLIRGATRDDDSGPYNYSSLLACGRKSSQTPKLSGRHRIVVPH--IQPFKDEY 64

  Fly   244 DHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLF 308
            :..:|.:|.|:|||||||||:|:|:||.|||||.|||||:|:|:|||||.:.||.||:.|:|::.
Human    65 EKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVV 129

  Fly   309 VLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADIL 373
            ||.:.|:||..||.|:...||:|||...:||..:.::|....|:::.|||.:.||.||.:|||::
Human   130 VLTIIAIKDGLEDYRKYKIDKQINNLITKVYSRKEKKYIDRCWKDVTVGDFIRLSCNEVIPADMV 194

  Fly   374 LLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGAL 438
            ||.::||.|:|:|:|..||||:|||:|:||||:.|..|...|.||.||:|.::|...|.||.|.|
Human   195 LLFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDPEKFSSRIECESPNNDLSRFRGFL 259

  Fly   439 IHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIW 503
            .|...|||.:|.|.||||...::||:.:.|||||||||||:||||||||||||::|::.|.||:|
Human   260 EHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLW 324

  Fly   504 CVIILLILCVVGAIGCRMWLSSFT---HFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLY 565
            ||::|:|:|:.||:|..:|||.:.   .|.||....:.::..:...::|||.|::|||:||:|||
Human   325 CVMLLVIMCLTGAVGHGIWLSRYEKMHFFNVPEPDGHIISPLLAGFYMFWTMIILLQVLIPISLY 389

  Fly   566 VTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCV 630
            |:||:.|:.|::.|.::||.::.:.:...:|||:||.|:|||||::|:|||||||||||:||||.
Human   390 VSIEIVKLGQIYFIQSDVDFYNEKMDSIVQCRALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCS 454

  Fly   631 VNGSDYNHPP------------SELEKI----------YSKPGAPAPPLIPNDNLNSDMAQLTQG 673
            |.|.||.|..            ||.|..          .:||.||:...:.|..|.:..:....|
Human   455 VAGFDYCHEENARRLESYQEAVSEDEDFIDTVSGSLSNMAKPRAPSCRTVHNGPLGNKPSNHLAG 519

  Fly   674 TYLT----------PHAQR---------------------------------------------I 683
            :..|          ||:::                                             |
Human   520 SSFTLGSGEGASEVPHSRQAAFSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYI 584

  Fly   684 QEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTII 748
            .:|.:.|||||||:|.|.                  |.|        |||:
Human   585 IDFFIALAICNTVVVSAP------------------NQP--------RQKI-------------- 609

  Fly   749 NGPTTQPQVVSIP-------ADRYIRLAESRSVTPS----------PPPNLLFALPAQSHQPTLS 796
                ..|.:..:|       ...:.|.:..||.:||          .|...:..||..|.....|
Human   610 ----RHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSRLPLFSRMKPAS 670

  Fly   797 PISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSS 861
            |:    |...:...|||.....:...:.:....|.| .::|               ||...||
Human   671 PV----EEEVSQVCESPQCSSSSACCTETEKQHGDA-GLLN---------------GKAESLP-- 713

  Fly   862 KTGTIYRTADGRPL-----YEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEIL 921
                      |:||     ||||||||.|||.||.:|.|.|.:|:|.|::|.....|.. .:::|
Human   714 ----------GQPLACNLCYEAESPDEAALVYAARAYQCTLRSRTPEQVMVDFAALGPL-TFQLL 767

  Fly   922 KVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEG--------ILREQTQQ 978
            .:|||||.||.||:|||...|.::|:|||||||.||.:|   |..||:|        |:||:||:
Human   768 HILPFDSVRKRMSVVVRHPLSNQVVVYTKGADSVIMELL---SVASPDGASLEKQQMIVREKTQK 829

  Fly   979 LLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGI 1043
            .||.||::|||.|.:||:.::..:|.:|...|...|.|::|||..|.:|..:||:.|||||||||
Human   830 HLDDYAKQGLRTLCIAKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGI 894

  Fly  1044 EDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAIN 1108
            |||||:||||:|.:|..|||.:|:|||||.|||:||||:.||.....:|..|..:|:||....::
Human   895 EDRLQEGVPESIEALHKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMS 959

  Fly  1109 FYLTDMENDKTTSTLGYGQSLRKK------------QRALVVDGKTLTFILDPKSKLILPFLRLS 1161
            ..|.:::  |.|..|....||.:.            :..|::.||||.|.|  :..|...||.|:
Human   960 TILKELQ--KKTQALPEQVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFAL--QESLQKQFLELT 1020

  Fly  1162 KRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAA 1226
            ..|.:|:|||:|||||:.:||:|:..|.:.|||||||||||||||:||:|:|:|||||||||||:
Human  1021 SWCQAVVCCRATPLQKSEVVKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMAS 1085

  Fly  1227 DFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLML 1291
            ||.:.:|::|.:|||.||:|||.|||.|||||||||.|:|.|:||||.:|||||..|.|...|:.
Human  1086 DFAVSQFKHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIF 1150

  Fly  1292 YNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVAL 1356
            :||:|||.||:..||.:|.|:.:.|::.|.||::|:...||.||.||:.||||.|||||.|||..
Human  1151 FNLLFTSAPPVIYGVLEKDVSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFYQSLVCFFVPY 1215

  Fly  1357 CAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNC 1421
            ..|..||..|:.||..:..:.||..|:|..||.:|.|.:|:|.|:.|:.|::|||||:.::|:.|
Human  1216 FTYQGSDTDIFAFGNPLNTAALFIVLLHLVIESKSLTWIHLLVIIGSILSYFLFAIVFGAMCVTC 1280

  Fly  1422 FGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRIS--------------LCPDDSTK 1472
            ....:.||::.......|.:||.:|:|.:|:|||.:...::.|              |.|::.||
Human  1281 NPPSNPYWIMQEHMLDPVFYLVCILTTSIALLPRFVYRVLQGSLFPSPILRAKHFDRLTPEERTK 1345

  Fly  1473 VILQSKRERSRGEALLVT 1490
            .:   |:.|..|:...||
Human  1346 AL---KKWRGAGKMNQVT 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	34/49 (69%)
		ATPase-Plipid	250..1473	CDD:273734	556/1358 (41%)
		E1-E2_ATPase	302..>394	CDD:278548	39/91 (43%)
		Cation_ATPase	<880..965	CDD:289987	42/84 (50%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	115/258 (45%)
ATP10D	NP_065186.3	ATPase-Plipid	71..1327	CDD:273734	553/1339 (41%)
		PhoLip_ATPase_N	<71..122	CDD:292826	35/50 (70%)
		E1-E2_ATPase	128..>216	CDD:278548	38/87 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..531		4/24 (17%)
		Cation_ATPase	<727..807	CDD:289987	42/83 (51%)
		HAD_like	<1051..1082	CDD:304363	26/30 (87%)
		PhoLip_ATPase_C	1082..1327	CDD:292829	114/244 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	395	1.000	Domainoid score	I762
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68636
Inparanoid	1	1.050	971	1.000	Inparanoid score	I319
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm42056
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3512
SonicParanoid	1	1.000	-	-		X904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870