DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP8B2

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001354863.1	Gene:	ATP8B2 / 57198	HGNCID:	13534	Length:	1209	Species:	Homo sapiens

Alignment Length:	1330	Identity:	426/1330 - (32%)
Similarity:	665/1330 - (50%)	Gaps:	256/1330 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 RTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSF 265
            |.:|||.|.|.   ..:.|.: |||..|.          ..:..:...|:..|.|:|:||.:|:|
Human    13 RAQAPPSWSRK---KPSWGTE-EERRARA----------NDREYNEKFQYASNCIKTSKYNILTF 63

  Fly   266 IPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKR 330
            :|.||.|||..|||.||:|:::|..:|:||:......::|::.||.:|||||..:|..|..||.:
Human    64 LPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQ 128

  Fly   331 INNTTCRV-YDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGE 394
            :||...:| .:|..:   :.:|..:.||||:.|.||:.|.||:|||.:|:|.|:|||:|.:||||
Human   129 VNNRQSQVLINGILQ---QEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGE 190

  Fly   395 TNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESR 459
            ||:|.|:.:....|:..|...:||...|..:.|..||.:|.|.| :....:.|:|.:.:|||...
Human   191 TNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTL-YWKENKFPLSNQNMLLRGCV 254

  Fly   460 LKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLS 524
            |:||::..|:|::||.:||.|.|:...::||:.:::.||..|:|....|:.:.|:.|||..:|..
Human   255 LRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEH 319

  Fly   525 SF-THFPVPYLPPNKL--TANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLF 586
            .. ..|.| |||.::.  :|.......||:||:||..::|:||||::|:.::...:.|:.:..:|
Human   320 EVGMRFQV-YLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMF 383

  Fly   587 DAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPG 651
            ..:.....|.|...:.|||||:::||:|||||||:|.|:|.:|.:||..|......|........
Human   384 CMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGE 448

  Fly   652 APAP------PLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNAS 710
            .|.|      ||.....|..|.:.|.......||.   .||..:|::|:||:
Human   449 RPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHT---HEFFRLLSLCHTVM------------- 497

  Fly   711 GIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVT 775

Human   498 ----------------------------------------------------------------- 497

  Fly   776 PSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKI 840
                                              ||.     ||:
Human   498 ----------------------------------SEE-----KNE-------------------- 503

  Fly   841 TSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQI 905
                                   |.:|        |:|:||||.|||.||.::.....:|:|..|
Human   504 -----------------------GELY--------YKAQSPDEGALVTAARNFGFVFRSRTPKTI 537

  Fly   906 LVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEG 970
            .|.  ..|....|::|.:|.|::.||.||::||. ...:|.||.||||:    :|:...|:|.:.
Human   538 TVH--EMGTAITYQLLAILDFNNIRKRMSVIVRN-PEGKIRLYCKGADT----ILLDRLHHSTQE 595

  Fly   971 ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNL 1035
            :| ..|...|:.||.||||.||:|.:.|:...|.:|..|..:..::.::||.||...:.::|:|:
Human   596 LL-NTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDSREDRLASIYEEVENNM 659

  Fly  1036 TLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM---------- 1090
            .|||||.|||:||.|||||||.|..|.|.:|||||||.|||:||.||.|:.|..|
Human   660 MLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHT 724

  Fly  1091 ------ELIRLTARSRDAAETAIN--FYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFIL 1147
                  ||.:...:..|::.:..|  .|...:.:.|.||.|    .....:.|||::|.:|...|
Human   725 VLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVL----EAVAGEYALVINGHSLAHAL 785

  Fly  1148 DPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGV 1212
            :  :.:.|.||..:..|.:|:|||.||||||.:|::||:.....||||||||||||||:.|.:||
Human   786 E--ADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGV 848

  Fly  1213 GISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCG 1277
            |||||||:|||:|:|::..:|::|:||||.||.|.|.|:.:.:.||||||.||..:.||:..:||
Human   849 GISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCG 913

  Fly  1278 FSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILL 1342
            ||.|.:.||.::.|||:::||||.||:||:|:.|.|...::.|.||:.|:|.:.:...:|::.:.
Human   914 FSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIA 978

  Fly  1343 DALYQSLVIFFVALCAYAES--DVG-----IWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSI 1400
            ..:|.|:::||:....:|::  |.|     ...|..|:..|.:....|...::...||.::...|
Human   979 QGIYTSVLMFFIPYGVFADATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFI 1043

  Fly  1401 VLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH-------WLVIMLSTVVAVLPRLLL 1458
            ..||..:  |||::   .|:..|:...:...|....:|.:       ||.|:|:|||.::|.:..
Human  1044 WGSLAVY--FAILF---AMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAF 1103

  Fly  1459 TTVRISLCPDDS-----TKVILQSKRERSR 1483
            ..:|::|.||.|     |:::.:.::.:.|
Human  1104 RFLRLNLKPDLSDTVRYTQLVRKKQKAQHR 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	24/49 (49%)
		ATPase-Plipid	250..1473	CDD:273734	413/1269 (33%)
		E1-E2_ATPase	302..>394	CDD:278548	39/92 (42%)
		Cation_ATPase	<880..965	CDD:289987	32/84 (38%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	84/258 (33%)
ATP8B2	NP_001354863.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		10/26 (38%)
ATP8B2	NP_001354863.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830