DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP10A

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_077816.1	Gene:	ATP10A / 57194	HGNCID:	13542	Length:	1499	Species:	Homo sapiens

Alignment Length:	1493	Identity:	579/1493 - (38%)
Similarity:	817/1493 - (54%)	Gaps:	265/1493 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 TDSPPGSAAPAGRGHSRVG-SKT--DFILPPGHKEEPAREPSAPTSATGGRGHSRQASRSESIYT 198
            |:.|    .|.||...|.| ::|  ..:|||...|:||        |...:|..|:
Human     8 TEEP----GPPGRRRRREGRTRTVRSNLLPPPGAEDPA--------AGAAKGERRR--------- 51

  Fly   199 LRRTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLL 263
             ||.           |..:..|                                |:::|||||||
Human    52 -RRG-----------CAQHLAD--------------------------------NRLKTTKYTLL 72

  Fly   264 SFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASD 328
            ||:||||.|||||.||:||:||.|||:||.::||...:|:.||||:|.:||.:||:||..|..||
Human    73 SFLPKNLFEQFHRPANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAITAFRDLWEDYSRHRSD 137

  Fly   329 KRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDG 393
            .:||:..|.|:..|.::|....|:|:.|||.|.|..||..|||||||.:|||.|:|:|:|.:|||
Human   138 HKINHLGCLVFSREEKKYVNRFWKEIHVGDFVRLRCNEIFPADILLLSSSDPDGLCHIETANLDG 202

  Fly   394 ETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRES 458
            |||||||:|||||.|:.|.|.|..|.|.:|.:.|...|.||.|.:||..|::..:..|.||||..
Human   203 ETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRFRGCIIHDNGKKAGLYKENLLLRGC 267

  Fly   459 RLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWL 523
            .|:|||.:.|||:|||||||::|||||||||||::|:|||.||:|||::|:.:.:..|:|..:|:
Human   268 TLRNTDAVVGIVIYAGHETKALLNNSGPRYKRSKLERQMNCDVLWCVLLLVCMSLFSAVGHGLWI 332

  Fly   524 SSFTH----FPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVD 584
            ..:..    |.||....:.|:....:::.|.|.|::|||:||:||||:||:.|..||:.|:.::.
Human   333 WRYQEKKSLFYVPKSDGSSLSPVTAAVYSFLTMIIVLQVLIPISLYVSIEIVKACQVYFINQDMQ 397

  Fly   585 LFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNH----------- 638
            |:|.||:.|.:|||:||||:|||||:||:|||||||||||:||||.|:|.:|:|
Human   398 LYDEETDSQLQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTVSGVEYSHDANAQRLARYQ 462

  Fly   639 -PPSELEKIYSKPGAPA------------------------------------------------ 654
             ..||.|::..:.|:.:
Human   463 EADSEEEEVVPRGGSVSQRGSIGSHQSVRVVHRTQSTKSHRRTGSRAEAKRASMLSKHTAFSSPM 527

  Fly   655 -PPLIPNDNLNSDMAQLTQG-----------TYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMM 707
             ..:.|:..|...:::..:.           .:|:|....:.:|.:.|.|||||:| .:|.:...
Human   528 EKDITPDPKLLEKVSECDKSLAVARHQEHLLAHLSPELSDVFDFFIALTICNTVVV-TSPDQPRT 591

  Fly   708 NASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYI-RLAES 771
            ......|::    ||.         |.:.......|.:.:.:|.::   :.|:.|::.. :|..|
Human   592 KVRVRFELK----SPV---------KTIEDFLRRFTPSCLTSGCSS---IGSLAANKSSHKLGSS 640

  Fly   772 RSVTPSPPPNLLFALPAQSHQPTLSPISSSAESS--PNSESESPSPPMKNKSLSNSISPTGRAKA 834
            ...||| ...:|..|..:..||| |.|:|:..||  .|..||........:.|.
Human   641 FPSTPS-SDGMLLRLEERLGQPT-SAIASNGYSSQADNWASELAQEQESERELR----------- 692

  Fly   835 VINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLN 899
                                                     ||||||||.|||.||.:|:|.|:.
Human   693 -----------------------------------------YEAESPDEAALVYAARAYNCVLVE 716

  Fly   900 RSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCS 964
            |..:|:.|.:|..|.. .:|:|..|.|||.||.||:|:|...:.||.:|||||||.:|.:|.|||
Human   717 RLHDQVSVELPHLGRL-TFELLHTLGFDSVRKRMSVVIRHPLTDEINVYTKGADSVVMDLLQPCS 780

  Fly   965 HNSPEG----ILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLR 1025
            .....|    .:|.:||..|:.||.||||.|.:|||.|:..:|..|...|.|.|.||||.|..|.
Human   781 SVDARGRHQKKIRSKTQNYLNVYAAEGLRTLCIAKRVLSKEEYACWLQSHLEAESSLENSEELLF 845

  Fly  1026 DSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM 1090
            .|..:||:||.|||||||||||||||||||:.|..||:.:|||||||.|||:||||:.||.....
Human   846 QSAIRLETNLHLLGATGIEDRLQDGVPETISKLRQAGLQIWVLTGDKQETAVNIAYACKLLDHDE 910

  Fly  1091 ELIRLTARSRDAAETAINFYLTDMEN-------DKT---------------TSTLGYGQSLRKKQ 1133
            |:|.|.|.|::|....::..|..:::       :||               |||..      .::
Human   911 EVITLNATSQEACAALLDQCLCYVQSRGLQRAPEKTKGKVSMRFSSLCPPSTSTAS------GRR 969

  Fly  1134 RALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDG 1198
            .:||:||::|.:.|:  ..|...||.|:|:|.||||||||||||:.:||:|:.:|...|||||||
Human   970 PSLVIDGRSLAYALE--KNLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDG 1032

  Fly  1199 ANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNA 1263
            ||||||||:||||||||||||||||||:||.:|:||||||||:.||:|||.||:.|:|||||||.
Human  1033 ANDVSMIQVADVGVGISGQEGMQAVMASDFAVPKFRYLERLLILHGHWCYSRLANMVLYFFYKNT 1097

  Fly  1264 AFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRL 1328
            .||.|:||:|.:||||...|:||.||:.:||:|:|||||..||.|:.|..::||.||.|||:|:.
Human  1098 MFVGLLFWFQFFCGFSASTMIDQWYLIFFNLLFSSLPPLVTGVLDRDVPANVLLTNPQLYKSGQN 1162

  Fly  1329 GVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWT 1393
            ...|||..||..:.||.:||||.|.:...||.:|:|.::.:||.|....|...|:|..||.::||
Human  1163 MEEYRPRTFWFNMADAAFQSLVCFSIPYLAYYDSNVDLFTWGTPIVTIALLTFLLHLGIETKTWT 1227

  Fly  1394 VLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLL 1458
            .|:.::...|:..|:..|::|::.|..|:...:.||.:.......|.:|..:::.|.|:||||..
Human  1228 WLNWITCGFSVLLFFTVALIYNASCATCYPPSNPYWTMQALLGDPVFYLTCLMTPVAALLPRLFF 1292

  Fly  1459 TTVRISLCPDDSTKVILQSKRERSRGEALLVTWSRSTSASSIYRI-----TDYGSKNQIITTI 1516
            .:::..:.|..     ||..|:.:|......:..:.|.|..  |:     |::.|...:.|::
Human  1293 RSLQGRVFPTQ-----LQLARQLTRKSPRRCSAPKETFAQG--RLPKDSGTEHSSGRTVKTSV 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	32/49 (65%)
		ATPase-Plipid	250..1473	CDD:273734	548/1327 (41%)
		E1-E2_ATPase	302..>394	CDD:278548	46/91 (51%)
		Cation_ATPase	<880..965	CDD:289987	42/84 (50%)
		HAD_like	<1177..1240	CDD:304363	47/62 (76%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	107/244 (44%)
ATP10A	NP_077816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		17/66 (26%)
		PhoLip_ATPase_N	49..108	CDD:292826	37/111 (33%)
		ATPase-Plipid	61..1309	CDD:273734	551/1364 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..531		4/66 (6%)
		Cation_ATPase	<697..782	CDD:289987	43/85 (51%)
		HAD_like	<1026..1057	CDD:304363	29/30 (97%)
		PhoLip_ATPase_C	1057..1302	CDD:292829	107/244 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1311..1356		7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1464..1499
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	395	1.000	Domainoid score	I762
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	971	1.000	Inparanoid score	I319
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm42056
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3512
SonicParanoid	1	1.000	-	-		X904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870