DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33298 and atp10d

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_005156631.1	Gene:	atp10d / 571658	ZFINID:	ZDB-GENE-090313-231	Length:	1365	Species:	Danio rerio

Alignment Length:	1363	Identity:	568/1363 - (41%)
Similarity:	797/1363 - (58%)	Gaps:	131/1363 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 RTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVP 292
            |.||.:...|..:..|....| |..|.||||||||:||||.||.:||||.|||||:|:|||||||
Zfish    50 RRVVVSRWDPHHSEYRSFSKG-FQNNSIRTTKYTLISFIPMNLFQQFHRAANLYFLFLVLLNWVP 113

  Fly   293 EISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVG 357
            .:.||.||:.|||:..||.|.|.||..||.||...||:||||...||.|:.:||.:.:|.|:.||
Zfish   114 AVEAFQKEITMIPLAVVLTVIAFKDAMEDYRRYRYDKKINNTLTHVYSGKQQRYVERRWAEVCVG 178

  Fly   358 DIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRV 422
            |:|.|..||.:|||::||.:||..|||:|:|.:||||||||:|:|||...:..:.|||..|.||:
Zfish   179 DLVRLCCNEIIPADMVLLHSSDSNGVCHIETANLDGETNLKQRQVVRDLTQQGAEFVPENFSSRI 243

  Fly   423 EADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPR 487
            |.:.|...|.||.|.:.||...||.:.:|.||||...::||:.:.|||||||||||:|.||||||
Zfish   244 ECENPNNDLRRFRGFMEHPGKVRVGLHSENLLLRSCTVRNTETVIGIVVYAGHETKAMQNNSGPR 308

  Fly   488 YKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTY 552
            ||||::|:::|:||:|.|.:||::|.:.|||..:|||.... |:..:|.|...| :.:.::|||.
Zfish   309 YKRSKLERRLNLDVLWSVALLLLMCFIAAIGHGLWLSELED-PIFMIPDNTHPA-LAAFYMFWTM 371

  Fly   553 IVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTG 617
            |::|||:||:||||:||:.|:.|::.|.|::||::...:...:|||:||||:|||||::|:||||
Zfish   372 IIVLQVLIPISLYVSIEIVKLGQIYFIQNDLDLYNPVLDTGVQCRALNITEDLGQIQYLFSDKTG 436

  Fly   618 TLTENKMIFRRCVVNGSDYNHPPS-------------------ELEKIYSKPGAPAPPL------ 657
            |||||:|:||||.|.|::|.|..:                   .|....||.......|
Zfish   437 TLTENRMLFRRCTVAGTEYPHHENAVSLEQYEDQACGDVDRSLTLRSRTSKKSLSCKSLSCNRSS 501

  Fly   658 -----------------------------------IPNDNLNSDMAQLT--QGTYLTPHAQRIQ- 684
                                               :|:..|:..::.|:  ..:.|.|.|..|.
Zfish   502 VSLNTLTAESDTHSVHDTLCRHTTGAFSSTMECAVVPDPQLHMKLSTLSSPMRSPLRPDAAEISL 566

  Fly   685 --EFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTI 747
              :|.:.|.:||||:|                     :||:..:|..|...:.....|......:
Zfish   567 ILDFFLALTVCNTVVV---------------------SSPSQPRHVVQMPVVRTPLRSLEEMKAM 610

  Fly   748 INGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESES 812
            .       |.:|:|     |...|.:.....||:|...|.|:..         ||...|||..::
Zfish   611 F-------QKLSLP-----RFPHSPNTNTDTPPSLTKKLFARGR---------SASYFPNSNPQT 654

  Fly   813 PSPPMKNKSLSNSISPTGRAKAVINSKITSIATF---LNAKTQGKRMKLPSSKTGTIYRTADGRP 874
            |..|::: .:..|.:|:....|:|...::|...:   ...|.|.|......|::..  ...:...
Zfish   655 PVTPLES-PVKLSGTPSDTPPALITPALSSSGAWGEDAEDKKQAKDNAADESESDD--EDEEEEL 716

  Fly   875 LYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQ 939
            |||||||||.|||.||.:|.|.||.|||.|:||::|..|.. ...:|.||||.|:||.||:|||.
Zfish   717 LYEAESPDEAALVQAAKAYGCTLLGRSPEQVLVAVPGTGPL-SISLLHVLPFHSARKRMSVVVRH 780

  Fly   940 IGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYT 1004
            ..:.|:|:||||||:.||.:......:....:: |.||:.||:|||||||.|.:||:.|...:|.
Zfish   781 PLTGEVVVYTKGADNVIMELAKQAEDDFSREVM-ELTQRHLDQYAREGLRTLCVAKKVLGEQEYE 844

  Fly  1005 DWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLT 1069
            .|..||:..|.|:||||..|.:|..:||::|||||||||.||||:.|||||.:|..|||.|||||
Zfish   845 AWMKRHEYAETSIENREELLLESAERLETDLTLLGATGIVDRLQEEVPETIEALQEAGIKVWVLT 909

  Fly  1070 GDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQR 1134
            |||.|||||||::.||......::.....|::|.|..:.....::: ..|.:....|..:  ...
Zfish   910 GDKQETAINIAFACKLLRPTDHILMANCDSKEACEARLQELQLEVQ-QVTKADEPEGDCI--SDC 971

  Fly  1135 ALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGA 1199
            .||:||:||.:.|  :.:|...||.|:..|.||:|||||||||:.:|::|:::|.:.||||||||
Zfish   972 VLVIDGRTLDYAL--QKELQGAFLDLTCCCRSVICCRSTPLQKSQVVRLVRDKLEVMTLAIGDGA 1034

  Fly  1200 NDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAA 1264
            |||||||||||||||||||||||||::||.:.||::|.:|:|.||:|||.||:.|||||||||..
Zfish  1035 NDVSMIQMADVGVGISGQEGMQAVMSSDFAISRFKFLRKLILVHGHWCYARLANMILYFFYKNVM 1099

  Fly  1265 FVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLG 1329
            :|.|:||||.:|||||..|.:...|:.:||:|||:|||..||.||.|:.:.|||.|.|||:|:..
Zfish  1100 YVNLLFWYQFFCGFSGSTMTNSWVLIFFNLLFTSVPPLVYGVLDKDVSAETLLKLPDLYKSGQNS 1164

  Fly  1330 VAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTV 1394
            .||.|..|||.:|||.|||||.||:...|||.||:|::.|.:.|..|.|...|:|..||.|:.|.
Zfish  1165 QAYLPTTFWLNILDAFYQSLVCFFIPYFAYAGSDIGVFSFASPINGSALLIILLHQVIESRTLTW 1229

  Fly  1395 LHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLT 1459
            :|...::.|...:|.|.:::...|:.|....:.|.:.....:..:::||.:|:||:|:|||:|..
Zfish  1230 IHASLLIFSGLFYYAFVLLFSITCVTCNSPTNPYGIETKMMSEPLYYLVCVLTTVLALLPRMLSR 1294

  Fly  1460 TVRISLCPDDSTKVILQSKRERSRGE---ALLVTW--SRSTSASSIYRITDYGSKNQIITTIT 1517
            ....::||.|..|.   .|.||...:   :.|..|  :::|...|...:....|.|..|.::|
Zfish  1295 AFSNTICPSDLVKA---QKIERLSAQDYSSSLQKWKENKATQRVSSRPVPQNLSVNADIPSLT 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	35/49 (71%)
		ATPase-Plipid	250..1473	CDD:273734	550/1290 (43%)
		E1-E2_ATPase	302..>394	CDD:278548	47/91 (52%)
		Cation_ATPase	<880..965	CDD:289987	44/84 (52%)
		HAD_like	<1177..1240	CDD:304363	42/62 (68%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	109/244 (45%)
atp10d	XP_005156631.1	PhoLip_ATPase_N	69..122	CDD:292826	37/53 (70%)
		ATPase-Plipid	71..1309	CDD:273734	551/1294 (43%)
		E1-E2_ATPase	128..>215	CDD:278548	44/86 (51%)
		Cation_ATPase	<723..799	CDD:289987	42/76 (55%)
		HAD_like	<1027..1074	CDD:304363	38/46 (83%)
		PhoLip_ATPase_C	1058..1303	CDD:292829	109/244 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2044
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68636
Inparanoid	1	1.050	1007	1.000	Inparanoid score	I282
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm24567
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3512
SonicParanoid	1	1.000	-	-		X904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870