DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and atp8b5b

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_691903.2	Gene:	atp8b5b / 563450	ZFINID:	ZDB-GENE-120502-1	Length:	1189	Species:	Danio rerio

Alignment Length:	1305	Identity:	410/1305 - (31%)
Similarity:	641/1305 - (49%)	Gaps:	229/1305 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 LTLCNYNTGDK--FEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQ 273
            |:.|..|...|  .|||..|.          ..:..:.:.::..|.|:|:||.:.:|:|.||.||
Zfish     5 LSACGINVKKKKVEEERRLRA----------NDREFNLSFKYANNAIKTSKYNVFTFLPLNLFEQ 59

  Fly   274 FHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRV 338
            |.|:||.||:|:::|..:|:||:......::|:|.||.:|..|||.:|..|..:||::||....|
Zfish    60 FQRLANAYFVFLLILQLIPQISSLSWFTTVVPLLLVLSITLAKDLSDDITRHKNDKQVNNRKVEV 124

  Fly   339 -YDGE--TERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRR 400
             .|||  |||     |..::|||||.|.|||.|.||:|||.:|:|..:.||:|.:||||||||.:
Zfish   125 LIDGELKTER-----WMNVQVGDIVKLENNEFVTADLLLLSSSEPLNLIYIETAELDGETNLKVK 184

  Fly   401 EVVRGFEEM-QSIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTD 464
            :.:....|: ..|...:.|...|..:.|..:|.:|.|.|: ..||...:..|.:|||...|:||:
Zfish   185 QALTLTGELCNDIQRLAAFKGEVRCEPPNNRLDKFTGTLV-VGGETFALDNERILLRGCTLRNTE 248

  Fly   465 YIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHF 529
            :..|:|::.|.:||.|.|:....:||:.::..||:.|::....|..:|.:.:||..:|.....:.
Zfish   249 WCFGLVLFGGPDTKLMQNSGKSIFKRTSIDHLMNVLVLFIFGFLAFMCTILSIGNAIWEYQEGNS 313

  Fly   530 PVPYLP-PNKLTANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQ 593
            .:.:|| .:...|::.:...||:|::||..::|:||||::|:.::...:.|..:..::..:::..
Zfish   314 FIVFLPRADGANASLSAFLTFWSYVIILNTVVPISLYVSVEILRLGNSYFIDWDRKMYHVKSDTP 378

  Fly   594 TECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLI 658
            .:.|...:.||||||::||:|||||||:|.|.|.||.:||..|.       ::....|
Zfish   379 AQARTTTLNEELGQIKYIFSDKTGTLTQNIMTFNRCSINGKSYG-------EVVDFAG------- 429

  Fly   659 PNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPA 723
                         |...:|...:::.....:|          |..:...:...::|..::|
Zfish   430 -------------QRVEVTEKTEKVDFSWNLL----------ADPKFFFHDHKLVEAVKLG---- 467

  Fly   724 NLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPA 788
                                                                 ||..:..|.|.|
Zfish   468 -----------------------------------------------------SPEVHAFFRLLA 479

  Fly   789 QSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQG 853
            ..|  |:.|                                                  ..||||
Zfish   480 LCH--TVMP--------------------------------------------------EEKTQG 492

  Fly   854 KRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREY 918
            ..                   .|:|:||||.|||.||.::......|:|..|  |:...|....|
Zfish   493 DL-------------------FYQAQSPDEGALVTAARNFGFVFRARTPETI--SVVEMGIETTY 536

  Fly   919 EILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVP-CSHNSPEGILREQTQQLLDR 982
            |:|.||.|::.||.||::||. ...:::||.||||:.|...|.| ||.      :.|.|.:.|:.
Zfish   537 ELLAVLDFNNVRKRMSVIVRN-PEGKLMLYCKGADTIIYERLHPSCSK------VMEVTTEHLNE 594

  Fly   983 YAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRL 1047
            ||.||||.|.:|.:.|:...:.:|..||.|..::||:||.:|...:.::|.:|.|:||:.:||:|
Zfish   595 YAGEGLRTLALAYKDLDEDKFAEWRRRHHEASIALEDREEKLDAIYEEIEKDLILIGASAVEDKL 659

  Fly  1048 QDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTA--RSRDAAETAINFY 1110
            |||||:||..|..|.|.:|||||||.|||.||.||..:..::|..|.:.|  .:.:..|..:|..
Zfish   660 QDGVPQTIEQLAKADIKIWVLTGDKQETAENIGYSCNMLREEMTEIFIVAANTAEEVREELVNAR 724

  Fly  1111 LTDMENDKTTSTLGYGQSLRKKQR-----------ALVVDGKTLTFILDPKSKLILPFLRLSKRC 1164
            ............:...:.|.||.:           .||::|.:|.|.|....::.|  ||.:..|
Zfish   725 KKMSPESGDEPPMEKSRFLGKKSQVVEDEKVDGEYGLVINGHSLAFALQKDMQVEL--LRTACMC 787

  Fly  1165 ASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFT 1229
            .:|:|||.||||||.:|::||:.....||||||||||||||:.|.:|||||||||||||:::||:
Zfish   788 QTVICCRVTPLQKAQVVELVKKHKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGMQAVLSSDFS 852

  Fly  1230 LPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNL 1294
            ..:||||:||||.||.|.|.|:...:.||||||..|.|:.|||..:||||.|.:.|:.|:.||||
Zfish   853 FAQFRYLQRLLLVHGRWSYLRMCTFLRYFFYKNFTFTFVHFWYAFFCGFSAQTVYDEWYITLYNL 917

  Fly  1295 IFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAY 1359
            ::|:||.|.|.::|:.|.:....:.|.||..|::...:....|..|||.:.|.||::|||...|.
Zfish   918 VYTALPVLGISLFDQDVNDRWSFQYPQLYAPGQMNQYFSKMAFAKILLHSCYSSLILFFVPWAAM 982

  Fly  1360 AES------DVGIWEFGTTITASC-LFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSV 1417
            .::      |:..::....:..:| |.|..|...::...||.::...:..||..:  ||:.:...
Zfish   983 WDTVRDDGKDIADYQSFALLAQTCLLIAVSVQLGLDTYYWTAVNHFFLWGSLSVY--FAVTFTMY 1045

  Fly  1418 CMNCFGVRSSYWVIFVCFASAVH----WLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKV---IL 1475
            ....:.:.:|.:.......::::    ||.|.|:|::.|||.:....:.|...|..:.||   :.
Zfish  1046 SNGMYLIFTSSFPFIGTARNSLNQPNVWLTIFLTTILCVLPVVAKRFLFIQFKPTINDKVRHKVK 1110

  Fly  1476 QSKRE 1480
            |:|.|
Zfish  1111 QAKAE 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	22/49 (45%)
		ATPase-Plipid	250..1473	CDD:273734	397/1252 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	44/94 (47%)
		Cation_ATPase	<880..965	CDD:289987	36/85 (42%)
		HAD_like	<1177..1240	CDD:304363	40/62 (65%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	81/255 (32%)
atp8b5b	XP_691903.2	PhoLip_ATPase_N	25..87	CDD:292826	22/71 (31%)
		ATPase-Plipid	36..1107	CDD:273734	399/1254 (32%)
		Cation_ATPase	480..584	CDD:289987	46/183 (25%)
		HAD_like	<815..846	CDD:304363	26/30 (87%)
		PhoLip_ATPase_C	846..1100	CDD:292829	81/255 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.860