DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp8b1

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001001488.2	Gene:	Atp8b1 / 54670	MGIID:	1859665	Length:	1251	Species:	Mus musculus

Alignment Length:	1341	Identity:	416/1341 - (31%)
Similarity:	638/1341 - (47%)	Gaps:	319/1341 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313
            ::..|.|:|.||...:|:|.||.|||.|.||.||:.:::|..:|:||.......::|:|.|||:|
Mouse    91 KYASNAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGIT 155

  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVY-DGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRT 377
            |:|||.:|..|...||.|||.||.|. ||   |:|.:||::::|||::.|..|:.:|||||||.:
Mouse   156 AIKDLVDDVARHKMDKEINNRTCEVIKDG---RFKIIKWKDIQVGDVIRLKKNDFIPADILLLSS 217

  Fly   378 SDPQGVCYIDTCDLDGETNLKRR---EVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALI 439
            |:|..:||::|.:||||||||.:   |:...:.:::...  :.|...:|.:.|..:|.:|.|.|.
Mouse   218 SEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNL--ATFDGFIECEEPNNRLDKFTGTLF 280

  Fly   440 HPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWC 504
            . ..:..|:..:.:|||...::|||...|:|::||.:||.|.|:...|:||::::..||. :::.
Mouse   281 W-KNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNY-MVYT 343

  Fly   505 VIILLILCVVG-AIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTI 568
            :.|:|||...| |||...|.:...::..........|.:......||.||::|..|:|:||||::
Mouse   344 IFIVLILVSAGLAIGHAYWEAQVGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSV 408

  Fly   569 ELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG 633
            |:.::.|...|:.::.::.||.:...:.|...:.|:||||.:||:|||||||:|.|.|::|.:||
Mouse   409 EVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCING 473

  Fly   634 SDY-------NHPPSELEKI-YSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQ-----RIQE 685
            :.|       .|..|::|.: :|.            |..:|........||....|     .:::
Mouse   474 TIYGDHRDASQHSHSKIELVDFSW------------NTFADGKLAFYDHYLIEQIQSGKEPEVRQ 526

  Fly   686 FLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIING 750
            |..:|:||:||:|
Mouse   527 FFFLLSICHTVMV---------------------------------------------------- 539

  Fly   751 PTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSP 815
                        ||
Mouse   540 ------------DR--------------------------------------------------- 541

  Fly   816 PMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAES 880
                                                                  .||:..|:|.|
Mouse   542 ------------------------------------------------------IDGQINYQAAS 552

  Fly   881 PDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVR-QIGSQE 944
            |||.||||||.::....|.|:.|.|.||  ..|:.|.|.:|.:|.|:|.||.|||:|| ..||
Mouse   553 PDEGALVNAARNFGFAFLARTQNTITVS--ELGSERTYNVLAILDFNSDRKRMSIIVRTPEGS-- 613

  Fly   945 IVLYTKGADSSIMPVLVPCSHN-SPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWA 1008
            |.||.||||:.|...|    |. :|   .:::||..||.:|.|.||.|.:..:.:...::|:|..
Mouse   614 IRLYCKGADTVIYERL----HRMNP---TKQETQDALDIFASETLRTLCLCYKEIEEKEFTEWNN 671

  Fly  1009 RHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKP 1073
            :.....::..||:..|...:.::|.:|.|||||.|||:|||||||||:.|..|.|.:|||||||.
Mouse   672 KFMAASVASSNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKK 736

  Fly  1074 ETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYL-TDMENDKTTSTLGYGQSLR------- 1130
            |||.||.::.:|.|:...:    ....|     ||..| |.|||.:...    |.|.:
Mouse   737 ETAENIGFACELLTEDTTI----CYGED-----INSLLHTRMENQRNRG----GVSAKFAPPVYE 788

  Fly  1131 -----KKQRALVVDGKTLTFILDPKS-------KLILP--------------------------F 1157
                 .:.|||::.|..|..||..|.       ||..|                          |
Mouse   789 PFFPPGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNF 853

  Fly  1158 LRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQA 1222
            :.|:..|::|:|||.||.|||.:|.:||......|||||||||||:||:.|.:||||||||||||
Mouse   854 VDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQA 918

  Fly  1223 VMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQM 1287
            ||::|::..:||||:||||.||.|.|.|:.:.:.||||||.||..:.|||..:.|:|.|...:..
Mouse   919 VMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDW 983

  Fly  1288 YLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIF 1352
            ::.|||::::|||.|.:|:.|:.|::.|.|:.|.||..|:..:.:....|::.||..:..|:|:|
Mouse   984 FITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKRFFVSLLHGVLTSMVLF 1048

  Fly  1353 FVALCAY-------AESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLF 1410
            |:.|.||       .|:......|..|:.::.:........::...||.::..||..|:..:  |
Mouse  1049 FIPLGAYLQTVGQDGEAPSDYQSFAVTVASALVITVNFQIGLDTSYWTFVNAFSIFGSIALY--F 1111

  Fly  1411 AIVYDSVCMNCFGVRSSYWVIFVCFASAVH--------------WLVIMLSTVVAVLPRLLLTTV 1461
            .|::|   .:..|       |.|.|.||..              ||.|:|:..|.:||.:.:..:
Mouse  1112 GIMFD---FHSAG-------IHVLFPSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAIRFL 1166

  Fly  1462 RISLCPDDSTKVILQSKRERSRGEALLVTWSRSTSASSIYR 1502
            .:::.|.:|.|:  |..|:|.:.|.   .|.|   ..|::|
Mouse  1167 SMTIWPSESDKI--QKHRKRLKAEE---QWKR---RQSVFR 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	21/49 (43%)
		ATPase-Plipid	250..1473	CDD:273734	407/1309 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	45/92 (49%)
		Cation_ATPase	<880..965	CDD:289987	41/85 (48%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	80/265 (30%)
Atp8b1	NP_001001488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PhoLip_ATPase_N	86..142	CDD:292826	21/50 (42%)
		ATPase-Plipid	92..1179	CDD:273734	408/1312 (31%)
		E1-E2_ATPase	171..>234	CDD:278548	32/65 (49%)
		Cation_ATPase	534..628	CDD:289987	50/266 (19%)
		HAD_like	<875..919	CDD:304363	28/43 (65%)
		PhoLip_ATPase_C	919..1173	CDD:292829	80/265 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830