Protein Alignment CG33298 and Atp8b1

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_001001488.2
• Gene: Atp8b1 / 54670
• MGIID: 1859665
• Length: 1251
• Species: Mus musculus
• Alignment Length: 1343
• Identity: 416/1343 - (30%)
• Similarity: 637/1343 - (47%)
• Gaps: 323/1343 - (24%)

  Fly   249 QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVT 313
            ::..|.|:|.||...:|:|.||.|||.|.||.||:.:::|..:|:||.......::|:|.|||:|
Mouse    91 KYASNAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGIT 155

  Fly   314 AVKDLFEDRRRRASDKRINNTTCRVY-DGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRT 377
            |:|||.:|..|...||.|||.||.|. ||   |:|.:||::::|||::.|..|:.:|||||||.:
Mouse   156 AIKDLVDDVARHKMDKEINNRTCEVIKDG---RFKIIKWKDIQVGDVIRLKKNDFIPADILLLSS 217

  Fly   378 SDPQGVCYIDTCDLDGETNLKRR---EVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALI 439
            |:|..:||::|.:||||||||.:   |:...:.:::...  :.|...:|.:.|..:|.:|.|.|.
Mouse   218 SEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNL--ATFDGFIECEEPNNRLDKFTGTLF 280

  Fly   440 HPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWC 504
            . ..:..|:..:.:|||...::|||...|:|::||.:||.|.|:...|:||::::..||. :::.
Mouse   281 W-KNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNY-MVYT 343

  Fly   505 VIILLILCVVG-AIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTI 568
            :.|:|||...| |||...|.:...::..........|.:......||.||::|..|:|:||||::
Mouse   344 IFIVLILVSAGLAIGHAYWEAQVGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSV 408

  Fly   569 ELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG 633
            |:.::.|...|:.::.::.||.:...:.|...:.|:||||.:||:|||||||:|.|.|::|.:||
Mouse   409 EVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCING 473

  Fly   634 SDY-------NHPPSELEKIYSKPGAPAPPLIPND---NLNSDMAQLTQGTYLTPHAQ-----RI 683
            :.|       .|..|::|.:              |   |..:|........||....|     .:
Mouse   474 TIYGDHRDASQHSHSKIELV--------------DFSWNTFADGKLAFYDHYLIEQIQSGKEPEV 524

  Fly   684 QEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTII 748
            ::|..:|:||:||:|
Mouse   525 RQFFFLLSICHTVMV-------------------------------------------------- 539

  Fly   749 NGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESP 813
                          ||
Mouse   540 --------------DR------------------------------------------------- 541

  Fly   814 SPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEA 878
                                                                    .||:..|:|
Mouse   542 --------------------------------------------------------IDGQINYQA 550

  Fly   879 ESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVR-QIGS 942
            .||||.||||||.::....|.|:.|.|.||  ..|:.|.|.:|.:|.|:|.||.|||:|| ..||
Mouse   551 ASPDEGALVNAARNFGFAFLARTQNTITVS--ELGSERTYNVLAILDFNSDRKRMSIIVRTPEGS 613

  Fly   943 QEIVLYTKGADSSIMPVLVPCSHN-SPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDW 1006
              |.||.||||:.|...|    |. :|   .:::||..||.:|.|.||.|.:..:.:...::|:|
Mouse   614 --IRLYCKGADTVIYERL----HRMNP---TKQETQDALDIFASETLRTLCLCYKEIEEKEFTEW 669

  Fly  1007 WARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGD 1071
            ..:.....::..||:..|...:.::|.:|.|||||.|||:|||||||||:.|..|.|.:||||||
Mouse   670 NNKFMAASVASSNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGD 734

  Fly  1072 KPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYL-TDMENDKTTSTLGYGQSLR----- 1130
            |.|||.||.::.:|.|:...:    ....|     ||..| |.|||.:...    |.|.:
Mouse   735 KKETAENIGFACELLTEDTTI----CYGED-----INSLLHTRMENQRNRG----GVSAKFAPPV 786

  Fly  1131 -------KKQRALVVDGKTLTFILDPKS-------KLILP------------------------- 1156
                   .:.|||::.|..|..||..|.       ||..|
Mouse   787 YEPFFPPGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQK 851

  Fly  1157 -FLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGM 1220
             |:.|:..|::|:|||.||.|||.:|.:||......|||||||||||:||:.|.:||||||||||
Mouse   852 NFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGM 916

  Fly  1221 QAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMD 1285
            ||||::|::..:||||:||||.||.|.|.|:.:.:.||||||.||..:.|||..:.|:|.|...:
Mouse   917 QAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYE 981

  Fly  1286 QMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLV 1350
            ..::.|||::::|||.|.:|:.|:.|::.|.|:.|.||..|:..:.:....|::.||..:..|:|
Mouse   982 DWFITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKRFFVSLLHGVLTSMV 1046

  Fly  1351 IFFVALCAY-------AESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFY 1408
            :||:.|.||       .|:......|..|:.::.:........::...||.::..||..|:..:
Mouse  1047 LFFIPLGAYLQTVGQDGEAPSDYQSFAVTVASALVITVNFQIGLDTSYWTFVNAFSIFGSIALY- 1110

  Fly  1409 LFAIVYDSVCMNCFGVRSSYWVIFVCFASAVH--------------WLVIMLSTVVAVLPRLLLT 1459
             |.|::|   .:..|       |.|.|.||..              ||.|:|:..|.:||.:.:.
Mouse  1111 -FGIMFD---FHSAG-------IHVLFPSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAIR 1164

  Fly  1460 TVRISLCPDDSTKVILQSKRERSRGEALLVTWSRSTSASSIYR 1502
            .:.:::.|.:|.|:  |..|:|.:.|.   .|.|   ..|::|
Mouse  1165 FLSMTIWPSESDKI--QKHRKRLKAEE---QWKR---RQSVFR 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	378/1170 (32%)
Atp8b1	NP_001001488.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		P-type_ATPase_APLT_Dnf-like	94..1051	CDD:319770	378/1170 (32%)
		DUF2339	<959..>1171	CDD:431054	58/223 (26%)