DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and ATP8A2

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_057613.4	Gene:	ATP8A2 / 51761	HGNCID:	13533	Length:	1188	Species:	Homo sapiens

Alignment Length:	1304	Identity:	415/1304 - (31%)
Similarity:	626/1304 - (48%)	Gaps:	262/1304 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 NTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLY 281
            :.||:.|..: ||:..|         :.|.| :|..|:|.|.||::|:|:|:.|.||..|.||.:
Human    46 SVGDQLEAPA-RTIYLN---------QPHLN-KFRDNQISTAKYSVLTFLPRFLYEQIRRAANAF 99

  Fly   282 FIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRIN-NTTCRVYDGETER 345
            |:||.||..:|::|..|:...::|::.:|.:..:|::.||.:|..:|..:| ..|..:.:|   .
Human   100 FLFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNG---M 161

  Fly   346 YKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQ 410
            :..:.|:|:.|||||.:.|.:.:|||::||.:|:||.:||::|.:||||||||.|:.:....:||
Human   162 WHTIMWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADMQ 226

  Fly   411 SIFVPSKFVSRVEADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGH 475
            :..|..|....:|.:.|...||.|.|.|.......|.:..:.:|||.::|:||.::.|||||.||
Human   227 TREVLMKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGH 291

  Fly   476 ETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLT 540
            :||.|.|::....|||.||:..|:.::....|||::.:|.:.|...|..|  |....:......|
Human   292 DTKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSAGALYWNRS--HGEKNWYIKKMDT 354

  Fly   541 ANMESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEEL 605
            .:....:...|:|::...:||:||.||:|:.|..|...|:.:.|::....:.....|..|:.|||
Human   355 TSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEEL 419

  Fly   606 GQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIP-NDNLNSDMAQ 669
            ||::::|:|||||||.|.|.|::|.:.|..|.|.|....:..|......||  | :|:.:.|..:
Human   420 GQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFPELAREPSSDDFCRMPP--PCSDSCDFDDPR 482

  Fly   670 LTQGTY-LTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQK 733
            |.:... ..|.|..|||||.:||:|:||:    |.:|..|.
Human   483 LLKNIEDRHPTAPCIQEFLTLLAVCHTVV----PEKDGDNI------------------------ 519

  Fly   734 LLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPI 798

Human   520 ----------------------------------------------------------------- 519

  Fly   799 SSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKT 863

Human   520 ----------------------------------------------------------------- 519

  Fly   864 GTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDS 928
                       :|:|.||||.|||..|.........|:|..:::.  ..|..:.:.||.||.|.|
Human   520 -----------IYQASSPDEAALVKGAKKLGFVFTARTPFSVIIE--AMGQEQTFGILNVLEFSS 571

  Fly   929 SRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVM 993
            .||.||::|| ..|..:.||.||||:.|...|      |.:....|:|...|:.:|.||||.|.:
Human   572 DRKRMSVIVR-TPSGRLRLYCKGADNVIFERL------SKDSKYMEETLCHLEYFATEGLRTLCV 629

  Fly   994 AKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIASL 1058
            |...|:..:|.:|...:||....|::|.:||.:.:..:|.||.|||||.||||||.|||||||:|
Human   630 AYADLSENEYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATL 694

  Fly  1059 LSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKTTSTL 1123
            |.|.|.:|||||||.||||||.||.:|.:|.|.||.|...|.||...||..:.||:.|     .|
Human   695 LKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGN-----LL 754

  Fly  1124 GYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEEL 1188
            |     ::...||::||.||.:.|  ..::...||.|:..|.:|:|||.:||||:.:|.|||:.:
Human   755 G-----KENDVALIIDGHTLKYAL--SFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRV 812

  Fly  1189 NLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSR 1253
            ...|||||||||||.|||.|.|||||||.|||||...:|:.:.:|.|||:|||.||.|.|:|:::
Human   813 KAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTK 877

  Fly  1254 MILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLK 1318
            .|||.||||.....:..|:....|||||::.::..:.|||:|||:|||..:|::::...::.:|:
Human   878 CILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLR 942

  Fly  1319 NPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESD-------------VGIWEFG 1370
            .|.|||..:.|..:....||...::||..||::|:..:.| .|.|             ||...:.
Human   943 FPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKA-LEHDTVLTSGHATDYLFVGNIVYT 1006

  Fly  1371 TTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIF--- 1432
            ..:...||.|.|     |..:||....|::..|:.::.:|           ||:.|:.|...
Human  1007 YVVVTVCLKAGL-----ETTAWTKFSHLAVWGSMLTWLVF-----------FGIYSTIWPTIPIA 1055

  Fly  1433 --------VCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKRE---RSR--G 1484
                    :..:||..||.:.|     |....|:..|..........|.:|:..:|   :||  |
Human  1056 PDMRGQATMVLSSAHFWLGLFL-----VPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVLG 1115

  Fly  1485 EALL 1488
            :|:|
Human  1116 KAVL 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	22/49 (45%)
		ATPase-Plipid	250..1473	CDD:273734	399/1249 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	31/92 (34%)
		Cation_ATPase	<880..965	CDD:289987	32/84 (38%)
		HAD_like	<1177..1240	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	76/268 (28%)
ATP8A2	NP_057613.4	ATPase-Plipid	68..1106	CDD:273734	401/1256 (32%)
ATP8A2	NP_057613.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1162..1188
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830