Protein Alignment CG33298 and Atp11a

DIOPT Version :10

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: NP_056619.1
• Gene: Atp11a / 50770
• MGIID: 1354735
• Length: 1187
• Species: Mus musculus
• Alignment Length: 1329
• Identity: 393/1329 - (29%)
• Similarity: 619/1329 - (46%)
• Gaps: 275/1329 - (20%)

  Fly   228 RTVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWV- 291
            ||:...|..||...:...|. ::..|:|.::|||..:||||||.|||.|:||.||:.|.|:..:
Mouse    24 RTIYVGHKEPPPGAEAYIPQ-RYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLII 87

  Fly   292 -----PEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKW 351
                 |..|.       :|:.||:.|||:|..:||..|..:|..:|.  |.|:..:..:..:.:.
Mouse    88 DTPTSPVTSG-------LPLFFVITVTAIKQGYEDWLRHKADNAMNQ--CPVHFIQHGKLVRKQS 143

  Fly   352 QELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVV---RGFEEMQSIF 413
            ::|||||||.:..:||.|.|::.|.::...|.|::.|..||||::.|....|   :||.....:
Mouse   144 RKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADV- 207

  Fly   414 VPSKFVSRVEADAPTTKLYRFHGAL--IHPTGERV--PISTECLLLRESRLKNTDYIEGIVVYAG 474
              ....:.:|.:.|...||:|.|.:  .:...:.|  |:.:|.||||.:.||||:.|.|:.:|.|
Mouse   208 --DSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTG 270

  Fly   475 HETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPV---PYLPP 536
            .|||..||......|||.||:.||..:|..:.||:...::..:...:|.|.    |.   |:...
Mouse   271 METKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSE----PFRDEPWYNE 331

  Fly   537 NKLTANMESMWI-----FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTEC 596
            ...:....::::     |..::|:...:||:|:|||:|:.|.|..:.|..:.|:||.|..:....
Mouse   332 KTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLV 396

  Fly   597 RAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPND 661
            ...::.|||||:::||||||||||||.|.|:.|.:.|..|
Mouse   397 NTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVY------------------------- 436

  Fly   662 NLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLK 726
                           .||           .|||..:        :.::|||   ..|.:||...
Mouse   437 ---------------VPH-----------VICNGQV--------LPDSSGI---DMIDSSPGVC- 463

  Fly   727 HGKQRQKLLASSTSTTTTTTI--------INGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLL 783
             |::|::|...:.....|..:        ::||
Mouse   464 -GREREELFFRAICLCHTVQVKDDHCGDDVDGP-------------------------------- 495

  Fly   784 FALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLN 848
                               :.||:::|
Mouse   496 -------------------QKSPDAKS-------------------------------------- 503

  Fly   849 AKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAG 913
                                     .:|.:.||||:|||..........|....|.:.: :....
Mouse   504 -------------------------CVYISSSPDEVALVEGVQRLGFTYLRLKDNYMEI-LNREN 542

  Fly   914 ATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQ 978
            ....:|:|:||.|||.|:.||::|:.. :.||.|:.|||||||.|.::       ||.: :|.:.
Mouse   543 DIERFELLEVLTFDSVRRRMSVIVKST-TGEIYLFCKGADSSIFPRVI-------EGKV-DQVRS 598

  Fly   979 LLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGI 1043
            .::|.|.||||.|.:|.:.|....|.|.....|..:::|::||::|.:::.::|.:|.|||||.:
Mouse   599 RVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQSAKVALQDREKKLAEAYEQIEKDLVLLGATAV 663

  Fly  1044 EDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAIN 1108
            |||||:...:||.:|..|||.||||||||.|||....|:.|||.:..:|:.||.:..:  |.:::
Mouse   664 EDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKKLE--EQSLH 726

  Fly  1109 FYLTDME------NDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKS---------KLILPFL 1158
            ..|.|:.      :...|.....|.|.......|::||..|:.|:.|:.         :|   ||
Mouse   727 DVLFDLSKTVLRCSGSMTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYREL---FL 788

  Fly  1159 RLSKRCASVLCCRSTPLQKAYLVKVVK-EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQA 1222
            .:.:.|::|||||..|||||.:||::| .:.:..||||||||||||||..|.||:|:.|:||.||
Mouse   789 EICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQA 853

  Fly  1223 VMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQM 1287
            ...:|:.:|:|::|:::||.||::.|.|:|.::.||||||..|:|..|.||.:||||.|.:.|..
Mouse   854 ARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTA 918

  Fly  1288 YLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLY----KNGRLGVAYRPHDFWLILLDALYQS 1348
            ||.|||:.|||||.|...:.::.|..|:|.::|.||    ||..|  .:|...:|..|  .::.:
Mouse   919 YLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLYRDIAKNALL--RWRVFIYWTFL--GVFDA 979

  Fly  1349 LVIFFVALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGS 1406
            ||.||.|...:..:.|       |.|.|||.:....:....:..|::...||.::...|..||..
Mouse   980 LVFFFGAYFIFENTTVTINGQMFGNWTFGTLVFTVMVLTVTLKLALDTHYWTWINHFVIWGSLLF 1044

  Fly  1407 FYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDST 1471
            :..|::::..|.......:..|:|.....:|...||.|:|...|.:||.:|...:...|.| .:|
Mouse  1045 YIAFSLLWGGVIWPFLSYQRMYYVFISMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQLWP-TAT 1108

  Fly  1472 KVILQSKRERSRGE----ALLVTWSRSTS 1496
            :.....:.:.|..|    |.|.:|....|
Mouse  1109 ERTQNIQHQDSISEFTPLASLPSWGAQGS 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	352/1151 (31%)
Atp11a	NP_056619.1	P-type_ATPase_APLT_Dnf-like	47..986	CDD:319770	352/1151 (31%)
		MelB	<955..>1095	CDD:441813	35/143 (24%)