Protein Alignment CG33298 and ATP9B

DIOPT Version :9

• Sequence 1: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Sequence 2: XP_011524265.1
• Gene: ATP9B / 374868
• HGNCID: 13541
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 1349
• Identity: 351/1349 - (26%)
• Similarity: 578/1349 - (42%)
• Gaps: 329/1349 - (24%)

  Fly   199 LRRTEAPPW-----WKRL--TLCNY--NTGDKFEERSYRTVVPNHTVPPKTPKRDHPNGQFVGNK 254
            ::|.....|     ||.|  :.|.:  |...:.:|...|||...  .|.|..:: ||.     |.
Human    79 MQRKRGLEWFVCDGWKFLCTSCCGWLINICRRKKELKARTVWLG--CPEKCEEK-HPR-----NS 135

  Fly   255 IRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLF 319
            |:..||.:.:|||..|.|||....||||:.|....:||.:..........|:.|||.||..::..
Human   136 IKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLYTYWAPLGFVLAVTMTREAI 200

  Fly   320 EDRRRRASDKRINNTTCRVYDGETERYK-KVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGV 383
            ::.||...||.:|:   ::|...|.|.| :||..:::|||::.:..|:.:|:|::.||||:..|.
Human   201 DEFRRFQRDKEVNS---QLYSKLTVRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGS 262

  Fly   384 CYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIH-----PTG 443
            |:|.|..|||||:.|.:..|...:::.::.......:.|.|..|...::.|.|....     |..
Human   263 CFIRTDQLDGETDWKLKVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIH 327

  Fly   444 ERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMN--IDVIWCVI 506
            |.:.|..   .|..|.:..:..:.|:|:|.|.||:|::|.|.|:.|...::.::|  ...::..:
Human   328 ESLSIEN---TLWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNRLTKALFLAL 389

  Fly   507 ILLILCVV---GAIGCRMWLSSFTHFPVPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVTI 568
            :.|.:.:|   |.:|  .|..:...|                       :::...:||:||.|.:
Human   390 VALSIVMVTLQGFVG--PWYRNLFRF-----------------------LLLFSYIIPISLRVNL 429

  Fly   569 ELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNG 633
            ::.|.:..:.:..:      |....|..|...|.||||::.::.||||||||:|:|||:|.
Human   430 DMGKAVYGWMMMKD------ENIPGTVVRTSTIPEELGRLVYLLTDKTGTLTQNEMIFKRL---- 484

  Fly   634 SDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIV 698
                                                                             
Human   485 ----------------------------------------------------------------- 484

  Fly   699 GAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPAD 763
                              .:|                          |:..|..|..::.|...|
Human   485 ------------------HLG--------------------------TVSYGADTMDEIQSHVRD 505

  Fly   764 RYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISP 828
            .|.::.....                         .::..|:|..:::|.:|.:: ||:|:.|..
Human   506 SYSQMQSQAG-------------------------GNNTGSTPLRKAQSSAPKVR-KSVSSRIHE 544

  Fly   829 TGRAKAVINSKITSIATFLNAKTQGKRMKLPSSKTGTIYRT---------ADGRPLYEAESPDEL 884
            ..:| .|:...:|.:.               .|:.|....|         :|....|:|.||||:
Human   545 AVKA-IVLCHNVTPVY---------------ESRAGVTEETEFAEADQDFSDENRTYQASSPDEV 593

  Fly   885 ALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYT 949
            |||....|....|::|....:.:..| :|....:.||::.||.|..|.|.::||...:.||..|.
Human   594 ALVQWTESVGLTLVSRDLTSMQLKTP-SGQVLSFCILQLFPFTSESKRMGVIVRDESTAEITFYM 657

  Fly   950 KGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDW-------- 1006
            ||||.::.|::   .:|.   .|.|:...:    ||||||.||:||:.|....|.|:
Human   658 KGADVAMSPIV---QYND---WLEEECGNM----AREGLRTLVVAKKALTEEQYQDFEPMQSSSV 712

  Fly  1007 ------------------WARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPE 1053
                              .:|:.:.::|:.:|..::......||..:.||..||:||:||..|..
Human   713 ESTHSTYTCAHRRLPLCPQSRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQLQADVRP 777

  Fly  1054 TIASLLSAGISVWVLTGDKPETAINIAYSAKLF--TQQMELIRLTARSRDAAETAINFYLTDMEN 1116
            |:..|.:|||.:|:|||||.|||..||.|:.|.  ||.:.:.| ...||..|...:|.:
Human   778 TLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFR-QVTSRGEAHLELNAF------ 835

  Fly  1117 DKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLV 1181
                        .||...|||:.|.:|...|.....   .|:.|:.:|.:|:|||.:|.|||.:|
Human   836 ------------RRKHDCALVISGDSLEVCLKYYEH---EFVELACQCPAVVCCRCSPTQKARIV 885

  Fly  1182 KVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYW 1246
            .::::....||.|||||.|||||||.||.|:||.|:||.||.:||||::.:||::.|||:.||..
Human   886 TLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRN 950

  Fly  1247 CYDRLSRMILYFFYK-------NAAF--VFLIFWYQLYCGFSGQVMMDQMYLML-YNLIFTSLPP 1301
            .|.|.:.:..:..::       .|.|  ||......||.||          ||: |..|:|..|.
Human   951 SYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGF----------LMVGYATIYTMFPV 1005

  Fly  1302 LAIGVYDKRVAEDLLLKNPYLYKN---GRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESD 1363
            .:: |.|:.|..::.:..|.|||:   || .::::....|:::  ::||..::.:.||..:....
Human  1006 FSL-VLDQDVKPEMAMLYPELYKDLTKGR-SLSFKTFLIWVLI--SIYQGGILMYGALVLFESEF 1066

  Fly  1364 VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMN-CFGV-RS 1426
            |.:.....|   :.:...|:..|:.:|:|..|.|::..||||. |:.::.:    :| .||: |.
Human  1067 VHVVAISFT---ALILTELLMVALTVRTWHWLMVVAEFLSLGC-YVSSLAF----LNEYFGIGRV 1123

  Fly  1427 SYWVIF-VCFASAVHWL-VIMLSTVVAVLPRLLLTTVRISLCPDDSTKV 1473
            |:.... |.|.:.|.:| .:...|||:.||..:|..:|..|.|....|:
Human  1124 SFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKYLRRKLSPPSYCKL 1172

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	18/49 (37%)
		ATPase-Plipid	250..1473	CDD:273734	335/1287 (26%)
		E1-E2_ATPase	302..>394	CDD:278548	33/92 (36%)
		Cation_ATPase	<880..965	CDD:289987	29/84 (35%)
		HAD_like	<1177..1240	CDD:304363	34/62 (55%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	71/261 (27%)
ATP9B	XP_011524265.1	PhoLip_ATPase_N	125..182	CDD:292826	21/62 (34%)
		ATPase-Plipid	132..1169	CDD:273734	336/1288 (26%)
		E1-E2_ATPase	224..427	CDD:278548	56/230 (24%)
		Cation_ATPase	579..661	CDD:289987	29/82 (35%)
		HAD_like	<881..922	CDD:304363	23/40 (58%)
		PhoLip_ATPase_C	927..1166	CDD:292829	71/260 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930