DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and CG9981

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster

Alignment Length:	1295	Identity:	365/1295 - (28%)
Similarity:	573/1295 - (44%)	Gaps:	334/1295 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 NKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKE-----VAMIPVLFVLGV 312
            |::.|||||..:|:|.|..|||.|....||:.|.:      :|.|..|     |:::|:|||:.:
  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITI------VSFFVNETISPLVSLLPLLFVMII 86

  Fly   313 TAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRT 377
            ||:|:..||..|..|||.:|  |.||......:.:.:..|.:..||:|.:.|:..||.|::||::
  Fly    87 TALKEGLEDYSRSKSDKLVN--TARVTVIRNGKEEIINSQFIVPGDLVVVRNDGDVPCDLVLLQS 149

  Fly   378 SDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFV----------SRVEADAPTTKLY 432
            |.....|:::|.:||||||||            :|.||:.::          ..:..:..:..||
  Fly   150 SSADRKCFVNTANLDGETNLK------------TICVPTNYLLAGDHELQGKDCIVCEPSSADLY 202

  Fly   433 RFHGALI---------HPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRY 488
            .|:|.|.         ...|:.:|::.:.||||..|:|:|:.:.|..:|.|..||..||:.....
  Fly   203 TFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGN 267

  Fly   489 KRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFP---VPYLPPNKLTANMESMW--- 547
            |.:..|:.:|..::..::.::::.||      ::|.. .|..   ||.:|......|..|.|
  Fly   268 KSASSEKYINRFMVALIVGMIVVVVV------LYLIE-RHKEAKIVPTMPYQGPPTNFNSAWQIF 325

  Fly   548 -IFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHI 611
             .|.:::::...|:|:|.|:.||:.:|..:..:||::.|:|.||::.....|.|:.|||||:..:
  Fly   326 EDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNIL 390

  Fly   612 FTDKTGTLTENKMIFRRCVVNGSDY----NHPPS-------ELEKIYSKPGAPAPPLIPNDNLNS 665
            |:|||||||:|.|.|..|.|.|::|    .|..|       ||||                 |::
  Fly   391 FSDKTGTLTKNLMKFVNCYVPGTNYQLQNTHLVSEGTDEKFELEK-----------------LDA 438

  Fly   666 DMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQ 730
            |.|.|.:                .||:|:||.|                :|::|:
  Fly   439 DAAVLFE----------------ALAVCHTVEV----------------LQEVGD---------- 461

  Fly   731 RQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTL 795
              |.|.||.|.:                                             .|||
  Fly   462 --KTLESSESVS---------------------------------------------EQSH---- 475

  Fly   796 SPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPS 860
                                     .:|.:|...
  Fly   476 -------------------------LMSRNIVDR------------------------------- 484

  Fly   861 SKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATR-EYEILKVL 924
                           |:|.||||.||:....|.. .:.....|.:|.......|.: :::.|.||
  Fly   485 ---------------YQASSPDEKALLEGCASLG-LVYEGQENDVLSICRYPSAEKVQFKRLHVL 533

  Fly   925 PFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLR 989
            .|.|.|:.||::||. .|..|.||:|||:|:|.|   .|. .||   |.|||...:.:||:.|||
  Fly   534 EFSSERQRMSVIVRD-QSDTIWLYSKGAESAIFP---RCK-ASP---LVEQTDAQITKYAQNGLR 590

  Fly   990 ILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPET 1054
            .:.:.:|.|...:...:...:::....|.||...:...:..:|:.|.|||||.:||.||:.|.||
  Fly   591 TMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGATALEDALQEHVGET 655

  Fly  1055 IASLLSAGISVWVLTGDKPETAINIAYSAKLF---TQQMELIRLTARSRDAAETAINFYLTDMEN 1116
            :.:|.:||:.:|||||||.|||.||..:.:..   ::|..:|..|    :.||.....   ||..
  Fly   656 LEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIINTT----EPAELLARL---DMIG 713

  Fly  1117 DKTTSTLGYGQSLRKKQRALVVDGKTLTFILD--PKSKLILPFLRLSKRCASVLCCRSTPLQKAY 1179
            |             .:...|:|||.|:|.:|:  |:.     |..|:.||.:|||||.:||||:.
  Fly   714 D-------------DEPEVLIVDGTTITALLEHTPRQ-----FADLALRCRAVLCCRLSPLQKSE 760

  Fly  1180 LVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHG 1244
            :|.::|......|.|||||||||||||.|.:|:||:|:||.||...|||::.||..|.||.|.||
  Fly   761 IVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVHG 825

  Fly  1245 YWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDK 1309
            ::...||:.::|::.|||......:..||:|..:|...:.:.:||.|:::::.|.....:.:.||
  Fly   826 HYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICDK 890

  Fly  1310 RVAEDLLLKNPYLYK------NGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDV---- 1364
            ..:|:.||.:|.|||      ...:||      |.|.:|:...|..:|||.......:::|
  Fly   891 DYSEETLLSHPELYKPLAHNRQASMGV------FSLWILNGFVQCFIIFFFTYAMLNDANVLFNG 949

  Fly  1365 ----GIWEFGT-TITASCLFANLVHCAIEIRSWTVLHVLS------IVLSLGSFYLFAIVYDSVC 1418
                ....||| .||...:..||       :...|.|.::      |:.|:.:|.|...:|
  Fly   950 GQTASFQTFGTMLITIIVIVGNL-------KLLLVAHYMTYRNFAMILASIAAFMLTTYLY---- 1003

  Fly  1419 MNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSK 1478
             |.:.....|.|.....:|...||..::.:|..:||..::..|.     |...||.|:||
  Fly  1004 -NLYTSGELYDVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVN-----DMYRKVPLKSK 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	18/45 (40%)
		ATPase-Plipid	250..1473	CDD:273734	360/1288 (28%)
		E1-E2_ATPase	302..>394	CDD:278548	32/91 (35%)
		Cation_ATPase	<880..965	CDD:289987	31/85 (36%)
		HAD_like	<1177..1240	CDD:304363	33/62 (53%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	68/265 (26%)
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	17/43 (40%)
		ATPase-Plipid	28..1051	CDD:273734	360/1287 (28%)
		E1-E2_ATPase	84..>189	CDD:278548	37/118 (31%)
		Cation_ATPase	<489..568	CDD:289987	30/83 (36%)
		HAD_like	<758..807	CDD:304363	26/48 (54%)
		PhoLip_ATPase_C	804..1050	CDD:292829	69/268 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14244
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850