DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp11c

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_001032952.1	Gene:	Atp11c / 320940	MGIID:	1859661	Length:	1129	Species:	Mus musculus

Alignment Length:	1302	Identity:	402/1302 - (30%)
Similarity:	596/1302 - (45%)	Gaps:	265/1302 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 RLTLCNYNTGDKFEER-SYRTV-VPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLE 272
            |.||.....|:  |:| ..||| |.||.:....|   :...:|..|:|.::||||.:|:||||.|
Mouse     3 RRTLNRLCAGE--EKRVGTRTVFVGNHPISGTEP---YIAQRFCDNRIVSSKYTLWNFLPKNLFE 62

  Fly   273 QFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCR 337
            ||.|:||.||:.|.|:. |...:......:.:|:.||:.|||:|..:||..|..:|..:|.:.
Mouse    63 QFRRIANFYFLIIFLVQ-VTVDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSA-- 124

  Fly   338 VYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREV 402
            ||..|..:..:.:.::::|||:|.:..|||.|.|::||.:....|.||:.|..||||:|.|....
Mouse   125 VYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYA 189

  Fly   403 VRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGAL-IHPTG-ERV--PISTECLLLRESRLKNT 463
            ||....:.:........:.:|.:.|...||||.|.: |:... |.|  .:..|.|||:.:.||||
Mouse   190 VRDTIALCTAESIDNLRATIECEQPQPDLYRFVGRISIYSNSIEAVARSLGPENLLLKGATLKNT 254

  Fly   464 DYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTH 528
            ..|.|:.||.|.|||..||..|...|.|.||:.:|..:|..:.|||....|......:|.||
Mouse   255 KKIYGVAVYTGMETKMALNYQGKSQKCSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSS--- 316

  Fly   529 FPVPYLPP----NKLTANMESMWI------FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNV 583
               ||...    .|.....|:..:      |.:::|:...:||:|:|||:|:.|.|..|.|..:.
Mouse   317 ---PYNDEPWYNQKTQKERETFQVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDK 378

  Fly   584 DLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYS 648
            |.||.|.|:.......::.|||||:.::|||||||||||.|.|..|.::|..|.....|::.:..
Mouse   379 DFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEVDGLSQ 443

  Fly   649 KPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGII 713
            ..|    ||...|..:.:...|               ||..|.:|:||
Mouse   444 TDG----PLAYFDKADKNREAL---------------FLRALCLCHTV----------------- 472

  Fly   714 EVQQIGNSPANLKHGKQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSP 778
                      .:|                 |...::||                 .|....|
Mouse   473 ----------EMK-----------------TNDDVDGP-----------------VEGAGFT--- 490

  Fly   779 PPNLLFALPAQSHQPTLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSI 843

Mouse   491 ----------------------------------------------------------------- 490

  Fly   844 ATFLNAKTQGKRMKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVS 908
                                            |.:.||||:|||..|..:....|......|.|.
Mouse   491 --------------------------------YISSSPDEIALVKGAKRFGFTFLGNQNGYIRVE 523

  Fly   909 MPMAGATREYEILKVLPFDSSRKCMSIVVR-QIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGIL 972
             .......|||:|..|.|||.|:.||::|| |.|  :|:|:.|||||||.|.:  .||..
Mouse   524 -NQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKG--DILLFCKGADSSIFPRV--HSHQI----- 578

  Fly   973 REQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTL 1037
             |.|:..::|.|.:|.|.|.:|.:.:...|:....|:..|.:|:|::||.:|...|.::|:|:.|
Mouse   579 -ELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNL 642

  Fly  1038 LGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTA----- 1097
            :|||.:||:|||...|||.:|.:||:.||||||||.|||.:..|:.:||....||:.||.
Mouse   643 IGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEE 707

  Fly  1098 --RSRDAAETAINFYLTDMENDKTTSTLGYGQSLRK-----KQRALVVDGKTLTFILDPKS---- 1151
              |..|.....:..|...:.::...||    :||:|     ::..|::||.||:.||:...
Mouse   708 SERKEDRLHELLIEYRKKLLHEFPKST----RSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSS 768

  Fly  1152 ---KLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLR----TLAIGDGANDVSMIQMAD 1209
               |.|  ||::..:|.:|||||..|||||.:|::||   ||:    ||:|||||||||||..:.
Mouse   769 NNYKSI--FLQICMKCTAVLCCRMAPLQKAQIVRMVK---NLKGSPITLSIGDGANDVSMILESH 828

  Fly  1210 VGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQL 1274
            ||:||.|:||.||...:|:::|:|::|::|||.||:..|.|::.::.||||||..|:...|.||.
Mouse   829 VGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQF 893

  Fly  1275 YCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK--NGRLGVAYRPHDF 1337
            :||||.|.:.|..||.:||:.|||||.||..:.::.:..|.|..:|.||.  .|...:...|...
Mouse   894 FCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLH 958

  Fly  1338 WLILLDALYQSLVIFFVALCAYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVL 1395
            |..|  |.::..|.||.....:..|.:       |.|.|||.:....:|...:..|::.|.||.:
Mouse   959 WTFL--AAFEGTVFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWI 1021

  Fly  1396 HVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTT 1460
            :...|..||..:..|:..:..:.......:..|:|......|...||.|:|...:::.|.:||..
Mouse  1022 NHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIV 1086

  Fly  1461 VR 1462
            |:
Mouse  1087 VK 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	23/49 (47%)
		ATPase-Plipid	250..1473	CDD:273734	389/1260 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	32/91 (35%)
		Cation_ATPase	<880..965	CDD:289987	36/85 (42%)
		HAD_like	<1177..1240	CDD:304363	33/66 (50%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	77/249 (31%)
Atp11c	NP_001032952.1	P-type_ATPase_APLT_Dnf-like	42..974	CDD:319770	362/1142 (32%)
		Cyt_bd_oxida_II	<993..1083	CDD:376764	21/89 (24%)
		Di-leucine motif. /evidence=ECO:0000250\|UniProtKB:Q8NB49	1113..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820