DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp10b

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	NP_795973.2	Gene:	Atp10b / 319767	MGIID:	2442688	Length:	1474	Species:	Mus musculus

Alignment Length:	1452	Identity:	563/1452 - (38%)
Similarity:	808/1452 - (55%)	Gaps:	255/1452 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 W--WKRLTLCNYNTGDKFEERSYRTVVPNHTVP---PKTPKRDH---------PNG--------- 248
            |  ||      :.|.|.|.:.      |:.|.|   |:|.::.|         ||.
Mouse     9 WLRWK------WRTQDGFSQS------PSETTPLLSPETDRQSHNTAEQRVVYPNNSMCHQDWKK 61

  Fly   249 ---QFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFGKEVAMIPVLFVL 310
               ::.||.|.|||||||:|:|:||.|||||.|||||:|:|:|||:|.:..|.:|:.:.|:..||
Mouse    62 VCRRYPGNSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITIFPLATVL 126

  Fly   311 GVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLSNNETVPADILLL 375
            .:..|||..||.:|...|:.:|:.:.::|:.:.:||...:||::||||.|.:..||.||||||||
Mouse   127 LIIMVKDGIEDFKRYCFDREMNSASIQIYERKEQRYMLKRWQDVRVGDFVQMQCNEIVPADILLL 191

  Fly   376 RTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVEADAPTTKLYRFHGALIH 440
            .:|||.|||:::|.:||||||||:|.||:||.:.:..|.|..|.|.:..:.|...|.:|.|.:.|
Mouse   192 FSSDPSGVCHLETANLDGETNLKQRRVVKGFSQPEVQFQPEHFHSTIVCEKPNNHLSKFKGYMEH 256

  Fly   441 PTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYKRSQVEQQMNIDVIWCV 505
            |...|....:|.||||...::||:...|||:|||||||:||||||||||||::|:::|.|:.:|:
Mouse   257 PDQTRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCI 321

  Fly   506 IILLILCVVGAIGCRMWLSSFTHFP---VPYLPPNKLTANMESMWIFWTYIVILQVMIPLSLYVT 567
            .:|.::|::||:|..:|..:|...|   ||....|.|:..:...::|.|.|::|||:||:||||:
Mouse   322 GLLFLMCLIGAVGHSLWNGTFKEHPPFDVPDADGNFLSLALGGFYMFLTMIILLQVLIPISLYVS 386

  Fly   568 IELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTDKTGTLTENKMIFRRCVVN 632
            |||.|:.|||.:||::||:|.||:...:|||:||||:|||||:||:|||||||||||:||||.:.
Mouse   387 IELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIV 451

  Fly   633 GSDYNHP--------PSELEK-----------------------IYSKPGA-------------- 652
            ||:|.|.        |.||:.                       :.|:.||
Mouse   452 GSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMRSQGGAQPLRRCHSARVPIQ 516

  Fly   653 -------------PAPP----------LIPNDNLNSDM--AQLTQGTYLTPHAQ-------RIQE 685
                         ..||          :.|:.||.|.:  |.|...|..|..|:       .|.:
Mouse   517 SHCRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETSDTRPAKPSHSTTASIAD 581

  Fly   686 FLVVLAICNTVIVGAA--PHRDMMNASGIIEVQQIGNSPANLKHGK---------QRQKLLASST 739
            |.:.|.|||:|:|...  |.:            ::...|||...|.         ||.|||:.|.
Mouse   582 FFLALTICNSVMVSTTTEPRK------------RVTTPPANKALGTSLEKIQQLFQRLKLLSLSQ 634

  Fly   740 STTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSPISSSAES 804
            |.::|.               |:|  ..|.||..      |||          ||:.
Mouse   635 SFSSTA---------------PSD--TDLGESLG------PNL----------PTID-------- 658

  Fly   805 SPNSESESPSPPMKNKSLSNSI-SPTGRAKAVINSKI-TSIATFLNAKTQGKRMKLPSSKTGTIY 867
              :.|.:..|....:.|..... |.|.....::.|:. ||:...|.|.|
Mouse   659 --SDEKDDTSVCSGDCSTDGGYRSSTWEQGDILGSESGTSLEEGLEAPT---------------- 705

  Fly   868 RTADGRP--LYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFDSSR 930
             .:...|  .||||||||.|||:||.:|...|::|:|.|:.|.:|. |....:::|..|.|||.|
Mouse   706 -LSQDEPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQ-GICLTFDLLFTLGFDSVR 768

  Fly   931 KCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGI------LREQTQQLLDRYAREGLR 989
            |.||:|||...:.||::|||||||.||.:|...:..|...:      :|.:||:.||.|||:|||
Mouse   769 KRMSVVVRHPLTDEIIVYTKGADSVIMDLLEDPACESNIDVEKKLKRIRARTQKHLDLYARDGLR 833

  Fly   990 ILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPET 1054
            .|.:||:.::..|:..|.:..:|.|.||:|||..|.::...||::||||||||||||||:|||:|
Mouse   834 TLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLENHLTLLGATGIEDRLQEGVPDT 898

  Fly  1055 IASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDKT 1119
            ||:|..|||.:|||||||.|||:|||||.||..|...:..:...:::..|:.:|..|.|::....
Mouse   899 IAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSINTENQETCESILNCTLEDIKRFHE 963

  Fly  1120 TSTLGYGQSLRK-------------------KQRALVVDGKTLTFILDPKSKLILPFLRLSKRCA 1165
            ..     |..||                   .:..||:|||||..|.  :.||...||.|::.|.
Mouse   964 PQ-----QPARKLCGHRIPPKMPSVNSGAMAPEIGLVIDGKTLNAIF--QGKLENKFLELTQYCR 1021

  Fly  1166 SVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTL 1230
            ||||||||||||:.:||:|:::|::.||:||||||||||||.||:|:||||||||||||::||.:
Mouse  1022 SVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSDFAI 1086

  Fly  1231 PRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLI 1295
            .||.:|::|||.||:|||.||:||::|:||||..:|.|:||||.:|||||..|:|...::.:||.
Mouse  1087 ARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQMIFFNLF 1151

  Fly  1296 FTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYA 1360
            ||||||:..||.||.|:.:.||..|.|||:|:....|....||:.:.||.||||:.||:....|.
Mouse  1152 FTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFFIPYLTYR 1216

  Fly  1361 ESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVR 1425
            .||:.::.|||.|....|...|:|.|:|:::|||||.|.::.|...:::.:::|::.|:.|....
Mouse  1217 GSDIDVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVSLIYNATCVTCNSPT 1281

  Fly  1426 SSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTV-------------RISLCPDDSTKVILQS 1477
            :.|||:....:....:|:.:|:.|||:|||..|.::             :|...|.|...:.:|:
Mouse  1282 NPYWVMERQLSDPTFYLICLLTPVVALLPRYFLLSLQGTYGKSLISKAQKIDKLPIDKRNLEIQN 1346

  Fly  1478 KRERSRGEALLVTWSRSTSASS 1499
            .|.:.|....    |.|.|||:
Mouse  1347 WRSKQRPAPA----SASASASA 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	31/49 (63%)
		ATPase-Plipid	250..1473	CDD:273734	541/1355 (40%)
		E1-E2_ATPase	302..>394	CDD:278548	40/91 (44%)
		Cation_ATPase	<880..965	CDD:289987	41/84 (49%)
		HAD_like	<1177..1240	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	103/257 (40%)
Atp10b	NP_795973.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..43		7/29 (24%)
		P-type_ATPase_APLT_Dnf-like	68..1211	CDD:319770	504/1222 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..707		22/128 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1348..1421		7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	406	1.000	Domainoid score	I706
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	992	1.000	Inparanoid score	I307
Isobase	1	0.950	-	0	Normalized mean entropy	S3083
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D37083at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm44111
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3512
SonicParanoid	1	1.000	-	-		X904
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820