DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33298 and Atp11c

DIOPT Version :9

Sequence 1:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster
Sequence 2:	XP_006257661.1	Gene:	Atp11c / 317599	RGDID:	1564481	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	1282	Identity:	392/1282 - (30%)
Similarity:	593/1282 - (46%)	Gaps:	260/1282 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 RTV-VPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWV 291
            ||| |.||   |.:....:...:|..|:|.::||||.:|:||||.|||.|:||.||:.|.|:. |
  Rat    21 RTVFVGNH---PISGTEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ-V 81

  Fly   292 PEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRV 356
            ...:......:.:|:.||:.|||:|..:||..|..:|..:|.:|  ||..|..:..:.:.::::|
  Rat    82 TVDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKST--VYIIENAKRVRKESEKIKV 144

  Fly   357 GDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSR 421
            ||:|.:..:||.|.|::||.:....|.||:.|..||||:|.|....||...|:.:........:.
  Rat   145 GDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIELCTAESIDNLRAA 209

  Fly   422 VEADAPTTKLYRFHGAL-IHPTG-ERV--PISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLN 482
            :|.:.|...||:|.|.: |:... |.|  .:..|.|||:.:.||||..|.|:.||.|.|||..||
  Rat   210 IECEQPQPDLYKFVGRISIYSNSIEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALN 274

  Fly   483 NSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPY---------LPPNK 538
            ..|...|||.||:.:|..:|..:.|||....|......:|.|:      ||         ....:
  Rat   275 YQGKSQKRSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQST------PYNDEPWYNQKTQKER 333

  Fly   539 LTANMESMWI-FWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNIT 602
            .|..:..|:. |.:::|:...:||:|:|||:|:.|.|..|.|..:.|.||.|.|:.......::.
  Rat   334 ETFKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLN 398

  Fly   603 EELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDM 667
            |||||:.::|||||||||||.|.|..|.::|..|.....|::.:....|    ||...|..:.:.
  Rat   399 EELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEVDGLSQIDG----PLAYFDKADKNR 459

  Fly   668 AQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHGKQRQ 732
            .:|               ||..|.:|:||                 |::
  Rat   460 EEL---------------FLRALCLCHTV-----------------EIK---------------- 476

  Fly   733 KLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQPTLSP 797
                       |...::||....|..
  Rat   477 -----------TNDAVDGPIEGAQFT--------------------------------------- 491

  Fly   798 ISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKLPSSK 862

  Rat   492 ----------------------------------------------------------------- 491

  Fly   863 TGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKVLPFD 927
                         |.:.||||:|||..|..:....|......|.|. .......|||:|..|.||
  Rat   492 -------------YISSSPDEIALVKGAQKFGFTFLGNWNGHIRVE-NQRKEIEEYELLHTLNFD 542

  Fly   928 SSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGLRILV 992
            |.|:.||::||..|. :|:|:.|||||||.|.:  .||..      :.|:..::|.|.:|.|.|.
  Rat   543 SVRRRMSVIVRTQGG-DILLFCKGADSSIFPRV--HSHEI------DLTKVHVERNAMDGYRTLC 598

  Fly   993 MAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPETIAS 1057
            :|.:.:...|:.....:..|.:|:|::||.:|...|..:|:|:.|:|||.:||:|||...|||.:
  Rat   599 VAFKEIPPDDFERINVQLIEAKMALQDREEKLEKIFDVIETNMNLIGATAVEDKLQDQAAETIEA 663

  Fly  1058 LLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTA-------RSRDAAETAINFYLTDME 1115
            |.:||:.||||||||.|||.:..|:.:||....||:.||.       |..|.....:..|...:.
  Rat   664 LHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKEDRLHELLIEYRKKLL 728

  Fly  1116 NDKTTSTLGYGQSLRK-----KQRALVVDGKTLTFILDPKS-------KLILPFLRLSKRCASVL 1168
            ::...||    :||:|     ::..|::||.||:.||:...       |.|  ||::..:|.:||
  Rat   729 HEFPKST----RSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSSNNYKSI--FLQICMKCTAVL 787

  Fly  1169 CCRSTPLQKAYLVKVVKEELNLR----TLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFT 1229
            |||..|||||.:|::||   ||:    ||:|||||||||||..:.||:||.|:||.||...:|::
  Rat   788 CCRMAPLQKAQIVRMVK---NLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYS 849

  Fly  1230 LPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNL 1294
            :|:|::|::||||||:..|.|::.::.||||||..|:...|.||.:||||.|.:.|..||.:||:
  Rat   850 VPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNI 914

  Fly  1295 IFTSLPPLAIGVYDKRVAEDLLLKNPYLYK--NGRLGVAYRPHDFWLILLDALYQSLVIFFVALC 1357
            .|||||.||..:.::.:..|.|..:|.||.  .|...:...|..:|..|  |.::..|.||....
  Rat   915 CFTSLPILAYSLLEQHINIDALTADPRLYMKITGNAMLQLGPFLYWTFL--AAFEGTVFFFGTYF 977

  Fly  1358 AYAESDV-------GIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYD 1415
            .:..:.:       |.|.|||.:....:|...:..|::.|.||.::...|..||..:..|:..:.
  Rat   978 LFQTTSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWG 1042

  Fly  1416 SVCMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVR 1462
            .:.......:..|:|.....:|...||.|:|...:::.|.:||..|:
  Rat  1043 GIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVVK 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	23/49 (47%)
		ATPase-Plipid	250..1473	CDD:273734	385/1259 (31%)
		E1-E2_ATPase	302..>394	CDD:278548	32/91 (35%)
		Cation_ATPase	<880..965	CDD:289987	35/84 (42%)
		HAD_like	<1177..1240	CDD:304363	33/66 (50%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	77/249 (31%)
Atp11c	XP_006257661.1	PhoLip_ATPase_N	38..91	CDD:292826	23/53 (43%)
		ATPase-Plipid	41..1089	CDD:273734	384/1257 (31%)
		E1-E2_ATPase	98..>183	CDD:278548	32/86 (37%)
		Cation_ATPase	469..573	CDD:289987	43/266 (16%)
		HAD_like	<812..841	CDD:304363	20/28 (71%)
		PhoLip_ATPase_C	863..1090	CDD:292829	69/229 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820